Abstract

RIOS-GONZALEZ, Carlos Miguel. Efficacy of platelet-rich plasma in non-surgical aesthetic procedures: a systematic review and meta-analysis. Rev. cient. cienc. salud [online]. 2026, vol.8, e8896.  Epub Jan 31, 2026. ISSN 2664-2891.  https://doi.org/10.53732/rccsalud/2026.e8896.

Introduction. Platelet-rich plasma (PRP) is a promising autologous biological product widely used in aesthetic medicine. Its application for facial rejuvenation, alopecia, and scar remodeling has shown variable outcomes in clinical studies. Objective. To assess the effectiveness and safety of PRP in non-surgical aesthetic procedures based on clinical trial evidence. Materials and Methods. A systematic review and meta-analysis were conducted following PRISMA guidelines. Five databases were searched for studies published between 2014 and 2025. Randomized controlled trials (RCTs) evaluating PRP in adult patients undergoing non-surgical aesthetic treatments were included. Risk of bias was assessed using Cochrane RoB 2.0, and data were synthesized using fixed-effects models when heterogeneity was low. Results. Four RCTs met inclusion criteria. PRP demonstrated a statistically significant improvement in hair density (mean difference: 26.4 ± 6.2 units/cm²) and subjective facial texture improvement up to 35%. The pooled standardized mean difference (SMD) was 1.17 (95% CI: 0.51–1.84; p < 0.001). No serious adverse events were reported. Conclusion. PRP is an effective and safe option for treating androgenetic alopecia and facial rejuvenation in non-surgical aesthetic medicine. Standardization of protocols and long-term follow-up studies are warranted.

Keywords : platelet-rich plasma; aesthetic medicine; alopecia; facial rejuvenation; meta-analysis.

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