Abstract

MONTIEL, Dora et al. Chagasic Meningoencephalitis in a patient as the initial presentation of HIV infection. Rev. cient. cienc. salud [online]. 2026, vol.8, e8905.  Epub Feb 28, 2026. ISSN 2664-2891.  https://doi.org/10.53732/rccsalud/e8905.

A 57-year-old male farmer consults our hospital with a 30-day history of fever, weight loss, asthenia, anorexia. 48 hours before admission he presented incoherent speech. Upon admission the patient presented marked protein-calorie malnutrition, Glasgow 13/15, psychomotor excitation, CSF protein 907 mg/dl, glucose 30 mg/dl, leukocytes 16 cells/field with mononuclear predominance. Analysis of cerebrospinal fluid (CSF), direct examination showed trypomastigotes of Trypanosoma cruzi. Peripheral blood smear: hemoparasite compatible with Trypanosoma cruzi was observed. HIV serology (+), CD4 92, viral load 1,672,532 copies. The patient was treated with 5 mg/kg/day of benznidazole, received prophylaxis with TMS-SMS, azithromycin for advanced immunosuppression, and antiretroviral therapy. On day 10 of treatment, he developed a generalized skin rash, interpreted as an adverse effect of treatment. Benznidazole and trimethoprim sulfa were discontinued. Family members requested discharge. The patient's progress is unknown.

Keywords : trypanosoma cruzi; HIV; Chagas disease reactivation; benznidazole.

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