Abstract

HERNANDEZ, Jorge Andrés; THERAN, Juan Sebastián; GOMEZ, Jaime Alberto  and  DULCEY, Luis Andrés. Autoimmune polyglandular syndrome type 3: comprehensive approach in the management of a multisystem autoimmune disease. Rev. parag. reumatol. [online]. 2025, vol.11, n.2, pp.87-90.  Epub Dec 16, 2025. ISSN 2413-4341.  https://doi.org/10.18004/rpr/2025.11.02.87.

Autoimmune Polyendocrine Syndrome (APS) type 3 is a multisystem disorder characterized by the coexistence of multiple autoimmune conditions, including Hashimoto's thyroiditis, vitiligo, and celiac disease. This syndrome predominantly affects women, with a strong genetic predisposition associated with HLA haplotypes. Diagnosis requires the identification of at least two concurrent autoimmune diseases through detailed clinical history, laboratory testing, and specific diagnostic criteria. The therapeutic approach involves targeted interventions for each condition. Multidisciplinary collaboration and patient education are essential to improving quality of life, emphasizing the importance of early diagnosis and a personalized management strategy.

Keywords : thyroiditis; vitiligo; therapeutic approach.

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