Abstract

ZERON, Samara Mendieta  and  MARIN, Katherine Henao. Determination of growth status, levels of insulin growth factor type 1 (IGF-1) and vitamin D in patients with juvenile idiopathic arthritis treated at the IssemYm maternal and Child Hospital in Toluca de Lerdo, Mexico. Rev. parag. reumatol. [online]. 2019, vol.5, n.1, pp.13-19. ISSN 2413-4341.  https://doi.org/10.18004/rpr/2019.05.01.13-19.

Introduction: Growth delay has been described in children with juvenile idiopathic arthritis (JIA). Low vitamin D and insulin growth factor type 1 ( IGF-1) have been reported in this disease and seem to be related to the inadequete bone development and subsequent growht delay. Objetive: To determine growth status, levels of IGF-1, and Vitamin D in patients with JIA, acording to JIA subtype, received treatment, disease duration, age and gender of each patient. methods: Thirteen (13) children with JIA were included in this cohort sutdy . Patients were seen on an ambulatory basis from february through may of 2019. They recevied a clinical and anthropometric evaluation and serum was collected for Vitamin D[25(OH)D], IGF-1 and PTH measurement through chemiluminescent immunoessays. Growth charts approved by the CDC were also used to determine the patients’ growth status. Results and discussion: Vitamin D insuficiency was observed in 84,62% of patients, including those wiht growth delay (15,38%). Accordin to different authors, this could be a cause of such delay, but we are unable to draw conclusions with this study. Insulin growth factor 1 (IGF-1) was normal in all patients. Use of corticosteroids, disease duration, JIA subtype or treatment, age and gender were not found to be implicated as risk factors for growth delay. Conclusion: Growth delay was found in 15,38% of the patientes. Significant Vitamin D insuficiency was identified in patients with JIA, which suggest that further studies might identify variables that might correlated with this deficit.

Keywords : Juvenile idiopathic arthritis (JIA); insulin growth factor type 1 (IGF-1); vitamin D; parathyroid hormone (PTH); growth.

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