Resumen

TIPAS-CUASPUD, Jaqueline Paola et al. Acute generalized hydroxychloroquine-induced exanthematous pustulosis. Rev. virtual Soc. Parag. Med. Int. [online]. 2025, vol.12, n.1, e12142505.  Epub 16-Ene-2025. ISSN 2312-3893.  https://doi.org/10.18004/rvspmi/2312-3893/2025.e12142505.

Acute generalized exanthematous pustulosis (AGEP) is an uncommon skin reaction characterized by the presence of sterile pustules on an erythematous base, generally associated with drugs. We present the case of a 56-year-old female patient who developed a dermatologic clinical picture consisting of pustular lesions on the scalp, face, extremities, and genitals, accompanied by pruritus and fever after 22 days of treatment with 200 mg/day of hydroxychloroquine for the management of Sjögren's syndrome. Initially, it was diagnosed as varicella. However, as the lesions and fever persisted, a dermatologic evaluation was performed which led to the diagnosis of hydroxychloroquine-induced AGEP.

Palabras clave : acute generalized exanthematous pustulosis; drug-related side effects and adverse reactions; hydroxychloroquine..

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