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Revista Virtual de la Sociedad Paraguaya de Medicina Interna
versión On-line ISSN 2312-3893
Resumen
BENITEZ GONZALEZ, Ana Carolina et al. Sex differences in the evolution and treatment of non-valvular atrial fibrillation. Rev. virtual Soc. Parag. Med. Int. [online]. 2025, vol.12, n.1, e12122522. Epub 28-Sep-2025. ISSN 2312-3893. https://doi.org/10.18004/rvspmi/2312-3893/2025.e12122522.
Introduction:
Non-valvular atrial fibrillation (NVAF) is the most common cardiac arrhythmia in clinical practice. It has been observed that the clinical presentation and treatment of this arrhythmia vary according to gender.
Objective:
To determine sex differences in clinical outcome and response to antithrombotic treatment in hospitalized patients diagnosed with NVAF.
Methodology:
A retrospective, cross-sectional, observational study was conducted in patients hospitalized with NVAF at the Hospital Nacional de Itauguá, Paraguay, during 2024. Data were extracted from complete medical records containing the following variables: age, sex, type of antithrombotic treatment received, and thromboembolic risk (CHA₂DS₂-VASc) and bleeding (HAS-BLED) scores.
Results:
Three hundred seventy-one cases were included, 61.5% of which were female. Direct oral anticoagulants were used in 38.2% of women and 35% of men. Of the patients, 36.6% were discharged without recurrence, and 39.8% of men experienced a recurrence of NVAF.
Conclusion:
No differences were observed between men and women in clinical outcome and response to antithrombotic treatment in patients with NVAF, highlighting the importance of incorporating a gender perspective into the therapeutic approach.
Palabras clave : atrial fibrillation; stroke; fibrinolytics; anticoagulants; sex characteristics; clinical outcome.












