Resumen

SAAVEDRA TORRES, Jhan Sebastián. Cells and Sepsis: An integrated clinical-biological analysis. Rev. virtual Soc. Parag. Med. Int. [online]. 2024, vol.11, n.1, e11132405.  Epub 19-Oct-2024. ISSN 2312-3893.  https://doi.org/10.18004/rvspmi/2312-3893/2024.e11132405.

Research on cellular dynamics in sepsis has revealed key alterations that compromise both immune response and organ physiology. This review highlights the importance of considering persistent hyperinflammation, driven by cytokinemia, as well as immune system fatigue, which can lead to chronic inflammation and a weakened immune response. Additionally, cardiac and adrenal dysfunction exacerbates patient decompensation, contributing to the onset of hypotension and septic shock. This underscores the urgent need for a comprehensive approach to the treatment of associated complications. In this context, the review will focus on the underlying mechanisms linking sepsis to immune dysfunction, analyzing how cellular reprogramming and the activation of various inflammatory pathways impact clinical outcomes.

Palabras clave : sepsis; neutrophils; lymphocytes; inflammation; endothelial cells; capillary permeability; cytokines.

        · resumen en Español     · texto en Español     · Español ( pdf )