Resumen

IBANEZ FRANCO, Elvis Javier; GONZALEZ BAEZ, Clara Andrea; MONTOYA BUENO, Camila  y  ALDAMA CABALLERO, Arnaldo Benjamín Feliciano. Atypical Herpetic Infections in Immunocompromised Patients. An. Fac. Cienc. Méd. (Asunción) [online]. 2025, vol.58, n.3, pp.87-96. ISSN 1816-8949.  https://doi.org/10.18004/anales/2025.058.03.87.

Herpetic infections are caused by viruses of the Herpesviridae family. The most common are those responsible for oral herpes, genital herpes, and varicella-zoster. In immunocompromised patients, the clinical presentation may be atypical, making diagnosis difficult and leading to potentially lethal complications.

Three clinical cases of herpetic infections in immunocompromised patients are presented.

The first case involves a patient with HIV presenting with extensive ulcerative lesions. Differential diagnoses included fungal, mycobacterial, and viral infections; a diagnosis of herpes simplex virus type 2 infection was reached via molecular biology. The patient was treated with acyclovir and showed a favorable respons.

The second case describes a patient with HIV and a history of childhood varicella, presenting with sparse papulovesicular lesions distributed throughout the body. The initial suspicion was a fungal infection; however, the biopsy returned consistent with a herpes infection. The lesions resolved spontaneously without major complications, as the study results were returned late.

The third case involves a patient with systemic lupus erythematosus under immunosuppressive treatment, presenting with extensive vesiculobullous lesions on the trunk and extremities, with mucosal involvement. The initial suspicion was autoimmune bullous dermatosis, but the biopsy was consistent with a herpes infection. Due to multiorgan failure and a fatal outcome, the diagnosis was made post-mortem, and the patient did not receive specific treatment.

Palabras clave : viral infections; herpes virus infections; immunosuppression; case report..

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