Resumen

MARIN-ORTEGA, Cristhian Gabriel. Scope Review on Prion Diseases: Diagnosis and Management of Creutzfeldt-Jakob in Humans. Mem. Inst. Investig. Cienc. Salud [online]. 2025, vol.23, n.1, e23162502.  Epub 30-Dic-2025. ISSN 1812-9528.  https://doi.org/10.18004/mem.iics/1812-9528/2025.e23162502.

Prion diseases are fatal neurodegenerative disorders caused by abnormal proteins, presenting 27,872 cases in 34 countries between 1993 and 2020, notable for their rapid progression and lack of effective treatments, posing significant challenges in medical care. To analyze the clinical characteristics, diagnostic methods and management strategies of prion diseases, with a focus on Creutzfeldt-Jakob disease. A systematic search was conducted in PubMed, Scielo and Dialnet databases. Relevant studies were included and the importance of a multidisciplinary approach was emphasized. 272 articles were identified; after evaluation, 47 were included in the final review. Advances in diagnosis, use of biomarkers and imaging techniques are highlighted. However, management challenges remain, with symptomatic treatment and palliative care. Prion diseases present unique diagnostic and management challenges. The clinical features require a multidisciplinary approach for early diagnosis and the development of effective therapeutic strategies.

Palabras clave : Prions; Prion Proteins; Prion Diseases; Creutzfeldt-Jakob Disease.

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