<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2413-4341</journal-id>
<journal-title><![CDATA[Revista Paraguaya de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. parag. reumatol.]]></abbrev-journal-title>
<issn>2413-4341</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Reumatología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2413-43412019000200070</article-id>
<article-id pub-id-type="doi">10.18004/rpr/2019.05.02.70-73</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Esclerodermia y psoriasis, una asociación poco frecuente]]></article-title>
<article-title xml:lang="en"><![CDATA[Systemic sclerosis and cutaneous psoriasis, a rare association]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valinotti]]></surname>
<given-names><![CDATA[Vannia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Acosta-Colman]]></surname>
<given-names><![CDATA[Isabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Departamento de Reumatología]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>5</volume>
<numero>2</numero>
<fpage>70</fpage>
<lpage>73</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2413-43412019000200070&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2413-43412019000200070&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2413-43412019000200070&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen Se presenta un caso de psoriasis cutánea precediendo a la aparición de esclerosis sistémica, el cual constituye una asociación poco común. Se ha descrito que las vías inmunopatogénicas de ambas enfermedades son diferentes, sin embargo, comparten algunos aspectos fisiopatológicos y genéticos. El compromiso vascular y la disregulación del crecimiento epidérmico son factores comunes de ambas enfermedades. Se ha descrito asociación temporal entre ambas, en las que aparentemente la aparición de psoriasis precede a la de la esclerosis sistémica; generando diversas hipótesis que relacionan su posible etiología en común.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract A case of skin psoriasis is presented preceeding the onset of systemic sclerosis, which constitutes an uncommon association. Immunopathogenic pathways of both diseases are different, nonetheless, they share some physiopathologic and genetic features. Endothelial compromise and growth factors dysregulation are common factors between them. A temporary association between these diseases has been descripted, in which apparently the onset of psoriasis preceeds systemic sclerosis; generating diverse hypothesis that link a probable common ethiology.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Esclerosis sistémica]]></kwd>
<kwd lng="es"><![CDATA[Psoriais]]></kwd>
<kwd lng="en"><![CDATA[Systemic sclerosis]]></kwd>
<kwd lng="en"><![CDATA[psoriasis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yamamoto]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
<name>
<surname><![CDATA[Katayama]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Nishioka]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A Rare Association of Systemic Sclerosis with Psoriasis Vulgaris]]></article-title>
<source><![CDATA[The Journal of Dermatology]]></source>
<year>2000</year>
<volume>27</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>346-9</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Watad]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bragazzi]]></surname>
<given-names><![CDATA[NL]]></given-names>
</name>
<name>
<surname><![CDATA[McGonagle]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Systemic Sclerosis is Linked to Psoriasis and May Impact on Patients&#8216; Survival: A Large Cohort Study]]></article-title>
<source><![CDATA[J Clin Med.]]></source>
<year>2019</year>
<volume>8</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>521</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Harrison]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Herrick]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Griffiths]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Psoriasis and diffuse systemic sclerosis: a report of three patients]]></article-title>
<source><![CDATA[Rheumatology (Oxford)]]></source>
<year>2000</year>
<volume>39</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>213-5</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[DentonCP]]></surname>
<given-names><![CDATA[Khanna D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Systemic sclerosis]]></article-title>
<source><![CDATA[The Lancet]]></source>
<year>2017</year>
<volume>390</volume>
<numero>10103</numero>
<issue>10103</issue>
<page-range>1685-99</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rodriguez-Reyna TS]]></surname>
<given-names><![CDATA[Alosco S]]></given-names>
</name>
<name>
<surname><![CDATA[Ohashi M]]></surname>
<given-names><![CDATA[Cruz-Lagunas A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[HLA Class I and II Blocks Are Associated to Susceptibility, Clinical Subtypes and Autoantibodies in Mexican Systemic Sclerosis (SSc) Patients]]></article-title>
<source><![CDATA[PLoS ONE]]></source>
<year>2015</year>
<volume>10</volume>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[FitzGerald]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Haroon]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Giles]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
<name>
<surname><![CDATA[Winchester]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Concepts of pathogenesis in psoriatic arthritis: Genotype determines clinical phenotype]]></article-title>
<source><![CDATA[Arthritis Res. Ther.]]></source>
<year>2015</year>
<volume>17</volume>
<page-range>115</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sticherling]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Psoriasis and autoimmunity]]></article-title>
<source><![CDATA[Autoimmunity Reviews]]></source>
<year>2016</year>
<volume>15</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1167-70</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kuo]]></surname>
<given-names><![CDATA[CF]]></given-names>
</name>
<name>
<surname><![CDATA[Luo]]></surname>
<given-names><![CDATA[SF]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[KH]]></given-names>
</name>
<name>
<surname><![CDATA[See]]></surname>
<given-names><![CDATA[LC]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Doherty]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Familial risk of systemic sclerosis and co- aggregation of autoimmune diseases in affected families]]></article-title>
<source><![CDATA[Arthritis Res Ther.]]></source>
<year>2016</year>
<volume>18</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>231</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Di Meglio P]]></surname>
<given-names><![CDATA[Villanova F]]></given-names>
</name>
<name>
<surname><![CDATA[Navarini]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
<name>
<surname><![CDATA[Mylonas A]]></surname>
<given-names><![CDATA[Tosi I]]></given-names>
</name>
<name>
<surname><![CDATA[Nestle]]></surname>
<given-names><![CDATA[FO]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Targeting CD8(+) T cells prevents psoriasis development.]]></article-title>
<source><![CDATA[J. Allergy Clin. Immunol.]]></source>
<year>2016</year>
<volume>138</volume>
<page-range>274-6</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
