<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932024000100044</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2024.e11132405</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Células y sepsis: un análisis integrado clínico biológico]]></article-title>
<article-title xml:lang="en"><![CDATA[Cells and Sepsis: An integrated clinical-biological analysis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Saavedra Torres]]></surname>
<given-names><![CDATA[Jhan Sebastián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Pontificia Universidad Javeriana de Cali  ]]></institution>
<addr-line><![CDATA[Cali ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>11</volume>
<numero>1</numero>
<fpage>44</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932024000100044&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932024000100044&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932024000100044&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La investigación sobre la dinámica celular en la sepsis ha revelado alteraciones clave que comprometen tanto la respuesta inmune como la fisiología de los órganos. Esta revisión destaca la importancia de considerar la hiperinflamación persistente, impulsada por la citoquinemia, así como la fatiga del sistema inmunológico, que pueden llevar a una inflamación crónica y a una respuesta inmune debilitada. Además, la disfunción cardíaca y adrenal agrava la descompensación del paciente, contribuyendo a la aparición de hipotensión y choque séptico. Esto subraya la necesidad urgente de adoptar un enfoque integral en el tratamiento de las complicaciones asociadas. En este contexto, la revisión se centrará en los mecanismos subyacentes que vinculan la sepsis con la disfunción inmune, analizando cómo la reprogramación celular y la activación de diversas vías inflamatorias impactan los resultados clínicos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Research on cellular dynamics in sepsis has revealed key alterations that compromise both immune response and organ physiology. This review highlights the importance of considering persistent hyperinflammation, driven by cytokinemia, as well as immune system fatigue, which can lead to chronic inflammation and a weakened immune response. Additionally, cardiac and adrenal dysfunction exacerbates patient decompensation, contributing to the onset of hypotension and septic shock. This underscores the urgent need for a comprehensive approach to the treatment of associated complications. In this context, the review will focus on the underlying mechanisms linking sepsis to immune dysfunction, analyzing how cellular reprogramming and the activation of various inflammatory pathways impact clinical outcomes.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="es"><![CDATA[neutrófilos]]></kwd>
<kwd lng="es"><![CDATA[linfocitos]]></kwd>
<kwd lng="es"><![CDATA[inflamación]]></kwd>
<kwd lng="es"><![CDATA[células endoteliales]]></kwd>
<kwd lng="es"><![CDATA[permeabilidad capilar]]></kwd>
<kwd lng="es"><![CDATA[citocinas]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[neutrophils]]></kwd>
<kwd lng="en"><![CDATA[lymphocytes]]></kwd>
<kwd lng="en"><![CDATA[inflammation]]></kwd>
<kwd lng="en"><![CDATA[endothelial cells]]></kwd>
<kwd lng="en"><![CDATA[capillary permeability]]></kwd>
<kwd lng="en"><![CDATA[cytokines]]></kwd>
</kwd-group>
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