<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1812-9528</journal-id>
<journal-title><![CDATA[Memorias del Instituto de Investigaciones en Ciencias de la Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Mem. Inst. Investig. Cienc. Salud]]></abbrev-journal-title>
<issn>1812-9528</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Investigaciones en Ciencias de la Salud]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1812-95282019000100047</article-id>
<article-id pub-id-type="doi">10.18004/mem.iics/1812-9528/2019.017(01)47-053</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Actividad sinérgica in vitro de los alcaloides Crotsparina y Esparsiflorina aislados de Croton bomplandianum frente a Pseudomonas aeruginosa]]></article-title>
<article-title xml:lang="en"><![CDATA[In vitro synergic activity of the alkaloids Crotsparine and Sparsiflorine, isolated from Croton bomplandianum, against Pseudomonas aeruginosa]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarenga]]></surname>
<given-names><![CDATA[Nelson]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Química Departamento de Fitoquímica, Dirección de Investigación]]></institution>
<addr-line><![CDATA[San Lorenzo, ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>17</volume>
<numero>1</numero>
<fpage>47</fpage>
<lpage>53</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1812-95282019000100047&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1812-95282019000100047&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1812-95282019000100047&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Se evaluó la actividad sinérgica de los alcaloides crotsparina y esparsiflorina, aislados de Croton bomplandianum Baill. con los antibacterianos gentamicina y ciprofloxacina frente a Pseudomonas aeruginosa, microorganismo frecuentemente responsable de infecciones intrahospitalarias. Se empleó el método del &#8220;tablero de damas&#8221;. Se encontraron combinaciones que presentaban efecto sinérgico, logrando la reducción de 87,5% de la CMI de gentamicina, mientras que para ciprofloxacina se logró una reducción del 25,0%. Esto abre interesantes perspectivas sobre el uso combinado de productos naturales puros y fármacos en uso clínico para el tratamiento de infecciones producidas por este microrganismo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The synergistic activity of the alkaloids crotsparine and sparsiflorine, isolated from Croton bomplandianum Baill, was evaluated with the antibacterials gentamicin and ciprofloxacin against Pseudomonas aeruginosa, a microorganism frequently responsible for nosocomial infections. The checkerboard method was used. Combinations were found that had a synergic effect, achieving a reduction of 87.5% of the MIC of gentamicin, while for ciprofloxacin a reduction of 25.0% was observed. This opens interesting perspectives on the combined use of pure natural products and drugs in clinical use for the treatment of infections produced by this microorganism.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[crotsparina]]></kwd>
<kwd lng="es"><![CDATA[esparsiflorina]]></kwd>
<kwd lng="es"><![CDATA[Croton]]></kwd>
<kwd lng="es"><![CDATA[Pseudomonas]]></kwd>
<kwd lng="es"><![CDATA[gentamicina]]></kwd>
<kwd lng="es"><![CDATA[ciprofloxacina]]></kwd>
<kwd lng="en"><![CDATA[crotsparine]]></kwd>
<kwd lng="en"><![CDATA[sparsiflorine]]></kwd>
<kwd lng="en"><![CDATA[Croton]]></kwd>
<kwd lng="en"><![CDATA[Pseudomonas]]></kwd>
<kwd lng="en"><![CDATA[gentamicin]]></kwd>
<kwd lng="en"><![CDATA[ciprofloxacin]]></kwd>
</kwd-group>
</article-meta>
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