<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2664-2891</journal-id>
<journal-title><![CDATA[Revista científica ciencias de la salud]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. cient. cienc. salud]]></abbrev-journal-title>
<issn>2664-2891</issn>
<publisher>
<publisher-name><![CDATA[Universidad del Pacífico]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2664-28912025000100122</article-id>
<article-id pub-id-type="doi">10.53732/rccsalud/2025.e7122</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Desarrollo galénico de un gel a base de Magnolia officinalis con propiedades antimicrobianas para el tratamiento del acné]]></article-title>
<article-title xml:lang="en"><![CDATA[Galenic development of a Magnolia officinalis-based gel with antimicrobial properties for acne treatment]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Duarte]]></surname>
<given-names><![CDATA[Rocío Belén]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fretes de Aquino]]></surname>
<given-names><![CDATA[Sonia Lorena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cáceres Villalba]]></surname>
<given-names><![CDATA[María Paz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilera de Almada]]></surname>
<given-names><![CDATA[Margarita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Samaniego Silva]]></surname>
<given-names><![CDATA[Lourdes Raquel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Maidana de Larroza]]></surname>
<given-names><![CDATA[Gladys Mabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad del Nacional de Asunción Facultad de Ciencias Químicas ]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>7</volume>
<fpage>122</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2664-28912025000100122&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2664-28912025000100122&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2664-28912025000100122&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Introducción. El acné es una enfermedad inflamatoria multifactorial muy prevalente, cuyo tratamiento convencional con antibióticos y retinoides presenta limitaciones debido a efectos adversos, resistencia bacteriana y baja adherencia. Esto motiva la búsqueda de alternativas más seguras y eficaces, como los productos naturales. Magnolia officinalis contiene honokiol y magnolol, compuestos con actividad antimicrobiana y antiinflamatoria documentada. El desarrollo de formulaciones tópicas, como geles, permite optimizar la liberación cutánea, mejorar la estabilidad y facilitar su aplicación en piel grasa o acneica. Objetivo. Desarrollar y caracterizar un gel tópico a base de extracto de Magnolia officinalis con propiedades antimicrobianas para el tratamiento del acné. Materiales y métodos. Se formularon tres variantes de gel con diferentes proporciones de excipientes, seleccionándose la óptima según parámetros fisicoquímicos. Se realizaron controles de calidad (aspecto, pH, viscosidad, densidad e identificación del extracto por cromatografía en capa fina (TLC)). La actividad antimicrobiana se evaluó frente a Staphylococcus aureus ATCC 25923 mediante métodos de difusión en disco y en pocillos. Resultados. La formulación seleccionada mostró pH 5,5; viscosidad 159,7 cP; densidad 1,039 g/mL e identificación positiva del extracto por TLC. La evaluación antimicrobiana registró halos de inhibición promedio de 19,2 mm (discos) y 21,2 mm (pocillos) frente a S. aureus. Conclusión. El gel desarrollado con Magnolia officinalis presenta propiedades fisicoquímicas adecuadas y actividad antibacteriana in vitro, sugiriendo su potencial como alternativa tópica natural, segura y sostenible para el manejo del acné.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Introduction. Acne is a highly prevalent multifactorial inflammatory disease, and conventional treatments with antibiotics and retinoids are limited by adverse effects, bacterial resistance, and low patient adherence. This has driven the search for safer and more effective alternatives, such as natural products. Magnolia officinalis contains honokiol and magnolol, compounds with documented antimicrobial and anti-inflammatory activity. Topical formulations, such as gels, allow optimization of skin delivery, improved stability, and ease of application on oily or acne-prone skin. Objective. To develop and characterize a topical gel based on Magnolia officinalis extract with antimicrobial properties for acne treatment. Materials and Methods. Three gel variants with different excipient ratios were formulated, and the optimal formulation was selected based on physicochemical parameters. Quality controls were performed, including appearance, pH, viscosity, density, and extract identification by thin-layer chromatography (TLC). Antimicrobial activity was evaluated against Staphylococcus aureus ATCC 25923 using disk diffusion and agar well diffusion assays. Results. The selected formulation exhibited a pH of 5.5, viscosity of 159.7 cP, density of 1.039 g/mL, and positive extract identification by TLC. Antimicrobial testing showed average inhibition zones of 19.2 mm (disk diffusion) and 21.2 mm (well diffusion) against S. aureus. Conclusion. The Magnolia officinalis gel demonstrated suitable physicochemical properties and in vitro antibacterial activity, indicating its potential as a natural, safe, and sustainable topical alternative for acne management.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[antimicrobianos]]></kwd>
<kwd lng="es"><![CDATA[Magnolia officinalis]]></kwd>
<kwd lng="es"><![CDATA[acné]]></kwd>
<kwd lng="es"><![CDATA[geles]]></kwd>
<kwd lng="en"><![CDATA[antimicrobials]]></kwd>
<kwd lng="en"><![CDATA[Magnolia officinalis]]></kwd>
<kwd lng="en"><![CDATA[acne]]></kwd>
<kwd lng="en"><![CDATA[gels]]></kwd>
</kwd-group>
</article-meta>
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