<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2413-4341</journal-id>
<journal-title><![CDATA[Revista Paraguaya de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. parag. reumatol.]]></abbrev-journal-title>
<issn>2413-4341</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Reumatología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2413-43412022000200083</article-id>
<article-id pub-id-type="doi">10.18004/rpr/2022.08.02.83</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Dosaje de IL6 en pacientes críticos con covid-19 y su relación con la mortalidad en el Departamento de Cuidados Intensivos Adultos del Hospital de Clínicas. Paraguay]]></article-title>
<article-title xml:lang="en"><![CDATA[IL6 dosage in critical patients with COVID-19 and its relationship with mortality in the Adult Intensive Care Department of the Hospital de Clínicas. Paraguay]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Figueredo]]></surname>
<given-names><![CDATA[Belinda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Samudio]]></surname>
<given-names><![CDATA[Margarita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fontclara]]></surname>
<given-names><![CDATA[Lorena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fretes]]></surname>
<given-names><![CDATA[Federico]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ávila]]></surname>
<given-names><![CDATA[Silene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[Fredy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pederzani]]></surname>
<given-names><![CDATA[Marcelo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Caballero]]></surname>
<given-names><![CDATA[Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Galeano]]></surname>
<given-names><![CDATA[Néstor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bianco]]></surname>
<given-names><![CDATA[Hugo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Hospital de Clínicas, Departamento de Cuidados Intensivos Adultos]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Postgrado de Medicina Critica y Cuidados Intensivos Adultos]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>8</volume>
<numero>2</numero>
<fpage>83</fpage>
<lpage>88</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2413-43412022000200083&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2413-43412022000200083&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2413-43412022000200083&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Introducción: La nueva enfermedad por Coronavirus (COVID-19) se caracteriza por una grave afectación del tracto respiratorio inferior, produciendo en algunos pacientes una respuesta inflamatoria exagerada, conocida como tormenta de citoquinas, que muchas veces puede ser irreversible y fatal, que se desarrolla fundamentalmente en los pacientes con comorbilidades asociadas. El objetivo de este estudio fue caracterizar una población de pacientes críticos con neumonía por COVID-19, ingresados al Departamento de Cuidados Intensivos de Adultos, del Hospital de Clínicas de la Facultad de Ciencias Médicas, Universidad Nacional de Asunción, Paraguay entre agosto de 2020 a setiembre de 2021, en quienes se determinó los niveles de IL-6 (al ingreso y en el cuarto día), y se evaluó los posibles factores pronósticos de mortalidad entre los marcadores inflamatorios dosados en los días 1 y 4 de hospitalización. Materiales y método: se realizó un estudio observacional analítico de corte transverso. Los datos se obtuvieron a partir de las historias clínicas de los pacientes hospitalizados. agrupando los pacientes en fallecidos y sobrevivientes y los niveles de IL-6 por encima y por debajo de 40 pg/mL, medidos en los días 1 y 4 de hospitalización. Se utilizó la prueba de Mann Whitney para comparar medianas. Aquellas variables asociadas a mortalidad en el análisis bivariado se incluyeron en el análisis multivariado por regresión logística. Se consideró un valor significativo al valor de p menor a 0,05. Resultados: se incluyeron 107 pacientes críticos entre 21 y 75 años de edad (mediana 54 años RIC 21), 56,1% del sexo masculino. Se asociaron significativamente con la mortalidad en el análisis bivariado los pacientes con mayor a 40 pg./ml de IL6 al cuarto día, así como los niveles de Dímero D y ferritina. En el análisis multivariado (por regresión logística) no se identificó ningún factor independiente de mortalidad. La mortalidad global fue de 39,25%. Conclusión: En pacientes críticos con COVID-19, el dosaje de IL6 se encuentra aumenta-do al ingreso y su posterior ascenso indicaría una evolución progresiva de gravedad con probabilidades de desenlace desfavorable.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Introduction: The new Coronavirus disease (COVID-19) is characterized by a serious affectation of the lower respiratory tract, producing in some patients an exaggerated inflammatory response, known as a cytokine storm that can often be fatal and irreversible, and that develops fundamentally in patients with associated comorbidities. The objective of this study was to characterize a population of critical patients with COVID-19 pneumonia, admitted to the Department of Intensive Care for Adults, Hospital de Clínicas of the Faculty of Medical Sciences, National University of Asunción, Paraguay between August 2020 and September 2021, in whom the levels of IL-6 were determined (at admission and day four), and the possible prognostic factors of mortality among the inflammatory markers measured on those two days of hospitalization were evaluated. Materials and method: a cross-sectional analytical observational study was carried out. Data were obtained from the medical charts of hospitalized COVID-19 patients. Results: 107 critically ill patients between 21 and 75 years of age (median 54 years), 56.1% male, were included. Patients with IL-6 greater than 40 pg/ml on the fourth day, as well as D-dimer and ferritin levels, were significantly associated with mortality in the bivariate analysis. In the multivariate analysis (by logistic regression) no independent mortality factor was identified. Overall mortality was 39.25%. Conclusion: In COVID-19critical patients, the IL-6 dosage is increased on admission and its subsequent increase would indicate a progressive evolution of severity with a probability of an unfavorable outcome.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Covid-19]]></kwd>
<kwd lng="es"><![CDATA[pacientes críticos]]></kwd>
<kwd lng="es"><![CDATA[dosaje de IL6]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="es"><![CDATA[factores de riesgo]]></kwd>
<kwd lng="en"><![CDATA[Covid-19]]></kwd>
<kwd lng="en"><![CDATA[critical patients]]></kwd>
<kwd lng="en"><![CDATA[IL-6 dosage]]></kwd>
<kwd lng="en"><![CDATA[mortality]]></kwd>
<kwd lng="en"><![CDATA[risk factors]]></kwd>
</kwd-group>
</article-meta>
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