<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2413-4341</journal-id>
<journal-title><![CDATA[Revista Paraguaya de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. parag. reumatol.]]></abbrev-journal-title>
<issn>2413-4341</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Reumatología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2413-43412020000100011</article-id>
<article-id pub-id-type="doi">10.18004/rpr/2020.06.01.11-16</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Relación entre la duración de la enfermedad y características clínicas de pacientes con Artritis Reumatoide en dos centros de referencia]]></article-title>
<article-title xml:lang="en"><![CDATA[Relationship between disease duration and clinical features in patients with Rheumatoid Arthritis in two reference centers]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valinotti]]></surname>
<given-names><![CDATA[Vannia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Román]]></surname>
<given-names><![CDATA[Lourdes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Paats]]></surname>
<given-names><![CDATA[Astrid]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Glizt]]></surname>
<given-names><![CDATA[Romina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mallorquín]]></surname>
<given-names><![CDATA[Armando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ávila-Pedretti]]></surname>
<given-names><![CDATA[Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cabrera-Villalba]]></surname>
<given-names><![CDATA[Sonia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Departamento de Reumatología]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Previsión Social, Hospital Central Servicio de Reumatología ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<volume>6</volume>
<numero>1</numero>
<fpage>11</fpage>
<lpage>16</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2413-43412020000100011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2413-43412020000100011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2413-43412020000100011&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen  Introducción: Existen diferencias entre pacientes con Artritis Reumatoide (AR) de inicio y establecida que pueden condicionar calidad de vida y el pronóstico de la enfermedad.  Materiales y métodos: Estudio descriptivo, de corte trasversal, en una cohorte de pacientes con el diagnóstico de AR en seguimiento regular en dos hospitales de tercer nivel. Se completó un cuestionario con variables epidemiológicas, clínicas, laboratoriales y radiográficas, además del examen físico. Los pacientes fueron divididos en 3 grupos: 0 a 12 meses, de 13 a 60 meses y más de 60 meses de duración de enfermedad.  Resultados: Fueron incluidos 330 pacientes, con una duración media de enfermedad de 108,19±91.17 meses. Los pacientes con una duración de enfermedad menor a 12 meses presentan un IMC menor a 25 con mayor frecuencia (50% vs 24.9%, p 0.037), asimismo tenían un mayor promedio de NAT (3.20 ± 3.6 vs 1.64 ± 2.7, p 0.034), NAD (3.53 ± 4.13 vs 1.7 ± 2.77 p 0.015) y de EVA dolor (28.93 ± 30.14 vs 15.09 ± 19.79, p 0.011). Mientras que, en el grupo mayor a 60 meses, los pacientes son mayores (53.08 ±12 vs 48.23 ± 14, p 0.002), tienen erosiones (39% vs 21%, p 0.004) y osteoporosis con mayor frecuencia (23,5% vs 12,9%, p 0.023) y menor número de NAD (1.49 ± 2.5 vs 2.28 ± 3.3, p 0.018).  Conclusión: Los pacientes con menor duración de enfermedad tienen índices de actividad más elevados. Los pacientes con mayor duración de enfermedad tienen mayor frecuencia de enfermedad erosiva y osteoporosis, pero menores recuentos de articulaciones dolorosas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract  Introduction: There are differences between patients with early and established rheumatoid arthritis (RA) that can condition quality of life and prognosis of the disease.  Material and methods: Descriptive, cross-sectional study in a cohort of RA patients with regular follow-up visits in two third-level hospitals. A questionnaire with epidemiological, clinical, laboratory and radiographic variables was completed, in addition to physical examination. Patients were divided into 3 groups: 0 to 12 months, 13 to 60 months and more than 60 months of disease duration.  Results: 330 patients were included, with mean disease duration of 108.19 ± 91.17 months. Patients with less than 12 months of disease duration have a BMI of less than 25 more frequently (50% vs. 24.9%, p 0.037), they also have a higher average SJC (3.20 ± 3.6 vs. 1.64 ± 2.7, p 0.034), TJC (3.53 ± 4.13 vs. 1.7 ± 2.77, p 0.015) and pain VAS (28.93 ± 30.14 vs. 15.09 ± 19.79, p 0.011). Meanwhile, patients with more than 60 months disease duration are older (53.08 ± 12 vs. 48.23 ± 14, p 0.002), have a higher incidence of erosions (39% vs. 21%, p 0.004) and osteoporosis (23.5% vs. 12.9%, p 0.023) and a lower average TJC (1.49 ± 2.5 vs. 2.28 ± 3.3, p 0.018).  Conclusion: Patients with shorter disease duration have higher average activity indexes. Patients with longer disease duration have a higher frequency of erosive disease and osteoporosis but lower average tender joint counts.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Artritis Reumatoide]]></kwd>
<kwd lng="es"><![CDATA[duración]]></kwd>
<kwd lng="es"><![CDATA[de la enfermedad]]></kwd>
<kwd lng="en"><![CDATA[Rheumatoid arthritis]]></kwd>
<kwd lng="en"><![CDATA[disease duration]]></kwd>
</kwd-group>
</article-meta>
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