<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932026000100401</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2026.e13132601</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Estrategias de tratamiento inicial de la hipertensión arterial: posicionamiento de sociedades científicas en Paraguay]]></article-title>
<article-title xml:lang="en"><![CDATA[Initial treatment strategies for high blood pressure: position statements from scientific societies in Paraguay]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escalada Lesme]]></surname>
<given-names><![CDATA[Gustavo Lorenzo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castillo Vázquez]]></surname>
<given-names><![CDATA[Manuel Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Falcon Zorrilla]]></surname>
<given-names><![CDATA[Ramón Jesús María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duarte Flores]]></surname>
<given-names><![CDATA[Mercedes Raquel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Elizeche González]]></surname>
<given-names><![CDATA[Cesar Augusto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mongelós Font]]></surname>
<given-names><![CDATA[Jeaninne Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arbo Oze]]></surname>
<given-names><![CDATA[Gustavo Adolfo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Iriarte Rimassa]]></surname>
<given-names><![CDATA[Alejandro Augusto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barreto Cortesi]]></surname>
<given-names><![CDATA[Carlos Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Acuña Figueredo]]></surname>
<given-names><![CDATA[Alexis Omar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodas Aguinagalde]]></surname>
<given-names><![CDATA[Alba Graciela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Delvalle Duque Pérez]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Maidana Fernández]]></surname>
<given-names><![CDATA[Héctor Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cabral Oettinger]]></surname>
<given-names><![CDATA[Federico Gustavo René]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Miño Duarte]]></surname>
<given-names><![CDATA[María Elena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peralta Giménez]]></surname>
<given-names><![CDATA[Ruth María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Gómez]]></surname>
<given-names><![CDATA[Natalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Ruíz-Diaz]]></surname>
<given-names><![CDATA[Jorge]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chamorro Vera]]></surname>
<given-names><![CDATA[Lourdes Isabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Brítez Ranoni]]></surname>
<given-names><![CDATA[Angel David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortiz Albrecht]]></surname>
<given-names><![CDATA[Federico Tercero]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valiente Rivarola]]></surname>
<given-names><![CDATA[Martín Francois]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Sociedad Paraguaya de Hipertensión Arterial  ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Sociedad Paraguaya de Medicina Interna  ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Sociedad Paraguaya de Cardiología y Cirugía Cardiovascular  ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Sociedad Paraguaya de Gerontología y Geriatría  ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<volume>13</volume>
<numero>1</numero>
<fpage>401</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932026000100401&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932026000100401&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932026000100401&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la hipertensión arterial es la principal causa prevenible de enfermedad cardiovascular y muerte prematura a nivel global. En Paraguay, afecta a más del 38,6% de la población adulta, con tasas de control subóptimas a pesar de la disponibilidad de múltiples terapias.  Objetivo:  emitir una postura institucional basada en la evidencia disponible, que respalde el uso de terapia combinada como estrategia inicial en el tratamiento farmacológico de la hipertensión arterial en Paraguay.  Métodos:  se conformó un grupo multidisciplinario de expertos. Se revisaron guías internacionales (ESC/ESH, ACC/AHA, ISH, LASH) y datos epidemiológicos nacionales y regionales. Se aplicó la técnica Delphi modificada para consensuar las recomendaciones.  Resultados:  la evidencia demuestra que la terapia combinada inicial, especialmente en formulaciones a dosis fija, mejora el control tensional, reduce eventos cardiovasculares y favorece la adherencia terapéutica. Se identificaron subgrupos específicos en los que puede considerarse monoterapia. Conclusión: las distintas sociedades científicas nacionales recomiendan el uso de combinaciones farmacológicas desde el inicio en la mayoría de los pacientes con hipertensión arterial, promoviendo su implementación como estándar clínico nacional.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  High blood pressure is the leading preventable cause of cardiovascular disease and premature death worldwide. In Paraguay, it affects more than 38.6% of the adult population, with suboptimal control rates despite the availability of multiple therapies.  Objective:  To issue an institutional position based on available evidence supporting the use of combination therapy as an initial strategy in the pharmacological treatment of high blood pressure in Paraguay.  Methods:  A multidisciplinary group of experts was formed. International guidelines (ESC/ESH, ACC/AHA, ISH, LASH) and national and regional epidemiological data were reviewed. The modified Delphi technique was applied to reach consensus on the recommendations.  Results:  The evidence shows that initial combination therapy, especially in fixed-dose formulations, improves blood pressure control, reduces cardiovascular events, and promotes therapeutic adherence. Specific subgroups were identified in which monotherapy may be considered.  Conclusion:  The various national scientific societies recommend the use of drug combinations from the outset in most patients with high blood pressure, promoting their implementation as a national clinical standard.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[hipertensión]]></kwd>
<kwd lng="es"><![CDATA[terapia de modalidad combinada]]></kwd>
<kwd lng="es"><![CDATA[agentes antihipertensivos]]></kwd>
<kwd lng="es"><![CDATA[consenso]]></kwd>
<kwd lng="es"><![CDATA[Paraguay]]></kwd>
<kwd lng="en"><![CDATA[hypertension]]></kwd>
<kwd lng="en"><![CDATA[combination therapy]]></kwd>
<kwd lng="en"><![CDATA[antihypertensive agents]]></kwd>
<kwd lng="en"><![CDATA[consensus]]></kwd>
<kwd lng="en"><![CDATA[Paraguay]]></kwd>
</kwd-group>
</article-meta>
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