<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932026000100304</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2026.e13142604</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Endocarditis infecciosa protésica por Cardiobacterium hominis]]></article-title>
<article-title xml:lang="en"><![CDATA[Prosthesic infective endocarditis caused by Cardiobacterium hominis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Romero]]></surname>
<given-names><![CDATA[Rolando José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duque Fernández]]></surname>
<given-names><![CDATA[Keivin Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Appeceix]]></surname>
<given-names><![CDATA[Sabrina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Coyago]]></surname>
<given-names><![CDATA[Marco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garrido Hernández]]></surname>
<given-names><![CDATA[Giusti Valeria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales Méndez]]></surname>
<given-names><![CDATA[Eimar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vicente]]></surname>
<given-names><![CDATA[Gabriel Matías]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orozco]]></surname>
<given-names><![CDATA[Luis Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Braslavsky]]></surname>
<given-names><![CDATA[Ana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Italiano de Buenos Aires Departamento de Medicina Interna Servicio de Clínica Médica]]></institution>
<addr-line><![CDATA[Buenos Aires ]]></addr-line>
<country>Argentina</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Italiano de Buenos Aires Servicio de Medicina Interna Departamento de investigación]]></institution>
<addr-line><![CDATA[Buenos Aires ]]></addr-line>
<country>Argentina</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<volume>13</volume>
<numero>1</numero>
<fpage>304</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932026000100304&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932026000100304&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932026000100304&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La endocarditis infecciosa sobre válvulas protésicas es una entidad grave, asociada a elevada morbimortalidad. Los microorganismos del grupo HACEK constituyen una causa infrecuente y se caracterizan por un curso clínico subagudo y dificultades diagnósticas relacionadas con su crecimiento lento en hemocultivos. Dentro de este grupo, Cardiobacterium hominis es un patógeno poco frecuente, cuyo diagnóstico tardío puede retrasar el inicio del tratamiento adecuado. Se presenta el caso de un paciente masculino de 77 años, portador de prótesis valvulares aórtica y mitral biológicas, con múltiples cirugías cardíacas previas, que consultó por síndrome constitucional, fiebre y pérdida de peso. Los hemocultivos se positivizan tardíamente, aislándose Cardiobacterium hominis. El ecocardiograma transesofágico evidenció engrosamiento valvular protésico sin vegetaciones móviles. Se instauró tratamiento con ceftriaxona endovenosa durante seis semanas, con adecuada tolerancia y evolución clínica favorable. Debido al elevado riesgo quirúrgico, se indicó tratamiento supresivo prolongado con amoxicilina por vía oral, sin recaídas durante el seguimiento. La endocarditis protésica por C. hominis representa un desafío diagnóstico por su presentación insidiosa y hallazgos iniciales inespecíficos. El tratamiento antibiótico dirigido y prolongado es fundamental para un desenlace favorable y, en pacientes seleccionados con contraindicación quirúrgica, la terapia supresiva oral puede considerarse una estrategia terapéutica válida.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Infectious endocarditis on prosthetic valves is a serious condition associated with high morbidity and mortality. Microorganisms in the HACEK group are an uncommon cause and are characterised by a subacute clinical course and diagnostic difficulties related to their slow growth in blood cultures. Within this group, Cardiobacterium hominis is a rare pathogen, whose late diagnosis can delay the initiation of appropriate treatment. We present the case of a 77-year-old male patient with biological aortic and mitral valve prostheses and multiple previous cardiac surgeries who consulted for constitutional syndrome, fever, and weight loss. Blood cultures became positive late, isolating C. hominis. Transoesophageal echocardiography showed prosthetic valve thickening without mobile vegetations. Treatment with intravenous ceftriaxone was initiated for six weeks, with adequate tolerance and favourable clinical evolution. Due to the high surgical risk, prolonged suppressive treatment with oral amoxicillin was indicated, with no relapses during follow-up. Prosthetic endocarditis caused by C. hominis represents a diagnostic challenge due to its insidious presentation and initial non-specific findings. Targeted and prolonged antibiotic treatment is essential for a favourable outcome and, in selected patients with surgical contraindications, oral suppressive therapy may be considered a valid therapeutic strategy.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cardiobacterium hominis]]></kwd>
<kwd lng="es"><![CDATA[endocarditis bacteriana]]></kwd>
<kwd lng="es"><![CDATA[válvula aórtica]]></kwd>
<kwd lng="es"><![CDATA[antibióticos betalactámicos]]></kwd>
<kwd lng="es"><![CDATA[profilaxis antibiótica]]></kwd>
<kwd lng="en"><![CDATA[Cardiobacterium hominis]]></kwd>
<kwd lng="en"><![CDATA[bacterial endocarditis]]></kwd>
<kwd lng="en"><![CDATA[aortic valve]]></kwd>
<kwd lng="en"><![CDATA[beta-lactam antibiotics]]></kwd>
<kwd lng="en"><![CDATA[antibiotic prophylaxis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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