<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932025000100416</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2025.e12142516</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Linfoma anaplásico de células grandes ALK negativo, presentación primaria en piel]]></article-title>
<article-title xml:lang="en"><![CDATA[ALK-negative anaplastic large cell lymphoma, primary presentation in the skin]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Adorno Villalba]]></surname>
<given-names><![CDATA[Erika Ayelen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oviedo]]></surname>
<given-names><![CDATA[Gabriela Belem]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Prieto Fariña]]></surname>
<given-names><![CDATA[María Gricelda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Católica Nuestra Señora de la Asunción Facultad de Ciencias de la Salud Hospital Central de IPS]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>12</volume>
<numero>1</numero>
<fpage>416</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932025000100416&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932025000100416&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932025000100416&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El linfoma anaplásico de células grandes ALK negativo con presentación cutánea primaria forma parte del espectro de enfermedades linfoproliferativas CD30+ junto con la papulosis linfomatoide. Se trata de una entidad poco frecuente, representando una mínima proporción de los linfomas no Hodgkin. Presentamos el caso de un paciente masculino de 63 años, que consultó por la presencia de múltiples lesiones cutáneas exofíticas de bordes mal definidos y tendencia a la confluencia, algunas con ulceraciones y centro necrótico, indoloras. Las mismas comprometían extremidades, tronco y miembros inferiores. No presentó fiebre, pérdida de peso ni otros síntomas sistémicos. Los estudios laboratoriales e imagenológicos fueron normales. Se realizó biopsia cutánea con inmunohistoquímica de una de las lesiones en antebrazo izquierdo, donde se realizó el diagnóstico de linfoma anaplásico de células grandes ALK negativo con presentación primaria en piel.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT ALK-negative anaplastic large cell lymphoma with primary cutaneous presentation is part of the spectrum of CD30+ lymphoproliferative diseases, along with lymphomatoid papulosis. It is a rare entity, accounting for a minimal proportion of non-Hodgkin lymphomas. We present the case of a 63-year-old male patient who consulted for the presence of multiple exophytic skin lesions with poorly defined edges and a tendency to coalesce, some with ulcerations and a necrotic center, which were painless. The lesions involved the extremities, trunk, and lower limbs. The patient did not present with fever, weight loss, or other systemic symptoms. Laboratory and imaging studies were normal. A skin biopsy with immunohistochemistry was performed on one of the lesions on the left forearm, where a diagnosis of ALK-negative anaplastic large cell lymphoma with primary presentation in the skin was made.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[linfoma anaplásico de células grandes]]></kwd>
<kwd lng="es"><![CDATA[linfoma anaplásico cutáneo primario de células grandes]]></kwd>
<kwd lng="en"><![CDATA[anaplastic large cell lymphoma]]></kwd>
<kwd lng="en"><![CDATA[primary cutaneous anaplastic large cell lymphoma]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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