<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932025000100408</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2025.e12142508</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Carcinoma neuroendocrino nasal avanzado: respuesta al tratamiento y manejo de anemia en paciente paliativo]]></article-title>
<article-title xml:lang="en"><![CDATA[Advanced nasal neuroendocrine carcinoma: response to treatment and management of anemia in a palliative patient]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Navas]]></surname>
<given-names><![CDATA[Jorge Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ochoa Castellanos]]></surname>
<given-names><![CDATA[Valentina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dulcey Sarmiento]]></surname>
<given-names><![CDATA[Luis Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Navas]]></surname>
<given-names><![CDATA[Valentina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Therán León]]></surname>
<given-names><![CDATA[Juan Sebastián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez Ayala]]></surname>
<given-names><![CDATA[Jaime Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Santander Facultad de medicina ]]></institution>
<addr-line><![CDATA[Bucaramanga ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de los Andes Facultad de medicina ]]></institution>
<addr-line><![CDATA[Mérida ]]></addr-line>
<country>Venezuela</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Autónoma de Bucaramanga Facultad de medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>12</volume>
<numero>1</numero>
<fpage>408</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932025000100408&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932025000100408&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932025000100408&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El carcinoma neuroendocrino nasal avanzado es un tumor maligno raro que se origina en la cavidad nasal y los senos paranasales. Se caracteriza por su alta agresividad y tiende a presentarse en etapas avanzadas, con infiltración de estructuras óseas subyacentes. El diagnóstico se confirma mediante biopsia e histología, que generalmente muestra una diferenciación neuroendocrina pobre. El tratamiento suele ser multimodal, incluyendo quimioterapia, radioterapia y en algunos casos, cirugía. La quimioterapia neoadyuvante con cisplatino y etopósido mejora la supervivencia en estos pacientes. Se presenta el caso de una paciente femenina de 54 años con carcinoma neuroendocrino nasal en estadio IV A, en tratamiento paliativo con quimioterapia basada en cisplatino y etopósido, y manejo de anemia ferropénica asociada. La paciente mostró una respuesta positiva al tratamiento, con seguimiento programado para monitorear su estado hematológico y ajustar el tratamiento de soporte.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Advanced nasal neuroendocrine carcinoma is a rare malignant tumor originating in the nasal cavity and paranasal sinuses. It is characterized by its high aggressiveness and tends to present in advanced stages, with infiltration of underlying bone structures. Diagnosis is confirmed by biopsy and histology, which usually shows poor neuroendocrine differentiation. Treatment is usually multimodal, including chemotherapy, radiotherapy, and in some cases, surgery. Neoadjuvant chemotherapy with cisplatin and etoposide improves survival in these patients. We present the case of a 54-year-old female patient with stage IV A nasal neuroendocrine carcinoma, in palliative treatment with chemotherapy based on cisplatin and etoposide, and management of associated iron deficiency anemia. The patient showed a positive response to treatment, with scheduled follow-up to monitor her hematologic status and adjust supportive treatment.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[carcinoma neuroendocrino]]></kwd>
<kwd lng="es"><![CDATA[anemia ferropénica]]></kwd>
<kwd lng="es"><![CDATA[quimioterapia.]]></kwd>
<kwd lng="en"><![CDATA[neuroendocrine carcinoma]]></kwd>
<kwd lng="en"><![CDATA[iron deficiency anemia]]></kwd>
<kwd lng="en"><![CDATA[chemotherapy.]]></kwd>
</kwd-group>
</article-meta>
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