<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932022000100062</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2022.09.01.62</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización de la sepsis en pacientes adultos del Hospital Nacional]]></article-title>
<article-title xml:lang="en"><![CDATA[Characterization of sepsis in adult patients of the Hospital Nacional]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ibáñez Franco]]></surname>
<given-names><![CDATA[Elvis Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fretes Ovelar]]></surname>
<given-names><![CDATA[Alma María Carmelita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duarte Arévalos]]></surname>
<given-names><![CDATA[Luis Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Giménez Vázquez]]></surname>
<given-names><![CDATA[Fabiola De Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Olmedo Mercado]]></surname>
<given-names><![CDATA[Edis Fabiola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Figueredo Martínez]]></surname>
<given-names><![CDATA[Hugo Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rondelli Martínez]]></surname>
<given-names><![CDATA[Lis Faviola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Itapuá Facultad de Medicina Postgrado en Medicina Interna]]></institution>
<addr-line><![CDATA[Encarnación ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>9</volume>
<numero>1</numero>
<fpage>62</fpage>
<lpage>70</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932022000100062&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932022000100062&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932022000100062&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la sepsis es una patología que afecta a un gran número de personas en todo el mundo, sigue siendo un problema de salud importante debido a su alta mortalidad.  Objetivos:  describir las características de la sepsis en pacientes adultos del Hospital Nacional, Itauguá, Paraguay.  Métodos:  estudio observacional, retrospectivo, descriptivo, de corte trasversal en el que se incluyó a todos los pacientes adultos, de ambos sexos, del periodo 2020-2021. La investigación fue aprobada por el Comité de Ética de la Universidad Nacional de Itapúa.  Resultados:  la muestra estuvo compuesta de 92 pacientes, la edad media fue de 59 ± 18 años, 56,5% correspondió al sexo masculino, 52,2% procedió de zonas urbanas, predominó la escolaridad primaria (46,8%). El 84,8% presentó alguna comorbilidad: la hipertensión arterial y la diabetes mellitus fueron las más frecuentes. El foco más frecuente de la sepsis fue pulmonar (35,9%), seguido de piel y partes blandas (26,1%). Los antibióticos más usados fueron cefalosporinas (22,8%), derivados de penicilina (17,4%) y combinación de quinolona y lincosamida (17,4%). En 38% la antibioticoterapia se inició posterior a 4 horas, en 31,5% entre 3 y 4 horas y en 30,4% antes de las 2 horas. Se aislaron gérmenes en 53,2% de los casos. El 65,2% requirió internación en terapia intensiva, de los cuales 70% falleció.  Conclusión:  la edad media fue 59 años y predominó el sexo masculino. La comorbilidad más frecuente fue la hipertensión arterial. El principal foco de origen fue el pulmonar. Los antibióticos más frecuentemente utilizados fueron cefalosporinas. Solamente en 30,4% de los casos se inició antibióticos antes de las 2 horas del diagnóstico. La mortalidad global fue de 45,65%.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Sepsis is a pathology that affects a large number of people around the world, and it continues to be a major health problem due to its high mortality.  Objectives:  To describe the characteristics of sepsis in adult patients of the Hospital Nacional Hospital, Itauguá, Paraguay.  Methods:  Observational, retrospective, descriptive, cross-sectional study in which all adult men and women from the 2020-2021 period were included. The research was approved by the Ethics Committee of the National University of Itapúa.  Results:  The sample consisted of 92 patients, the mean age was 59±18 years, 56.5% were male, 52.2% came from urban areas, primary schooling prevailed (46.8%). Comorbidities were present in 84.8%: arterial hypertension and diabetes mellitus were the most frequent. The most frequent focus of sepsis was pulmonary (35.9%), followed by skin and soft tissues (26.1%). The most used antibiotics were cephalosporins (22.8%), penicillin derivatives (17.4%) and a combination of quinolone and lincosamide (17.4%). In 38%, antibiotic therapy was started after 4 hours, in 31.5% between 3 and 4 hours and in 30.4% before 2 hours. Germs were isolated in 53.2% of the cases, 65.2% required hospitalization in intensive care, of which 70% died.  Conclusion:  The mean age was 59 years and male sex predominated. The most frequent comorbidity was arterial hypertension. The main source of origin was the lung. The most frequently used antibiotics were cephalosporins. Only in 30.4% of cases, antibiotics started within 2 hours of diagnosis. Overall mortality was 45.65%.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="es"><![CDATA[comorbilidad]]></kwd>
<kwd lng="es"><![CDATA[antibacterianos]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[mortality]]></kwd>
<kwd lng="en"><![CDATA[comorbidity]]></kwd>
<kwd lng="en"><![CDATA[antibacterials]]></kwd>
</kwd-group>
</article-meta>
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