<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932022000100055</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2022.09.01.55</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Índice neutrófilo-linfocito como predictor de desarrollo de neumonía grave por SARS-CoV-2 en el Hospital Nacional]]></article-title>
<article-title xml:lang="en"><![CDATA[Neutrophil-lymphocyte index as a predictor of the development of severe pneumonia due to SARS-CoV-2 in the Hospital Nacional]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escobar-Salinas]]></surname>
<given-names><![CDATA[Jorge Sebastián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sobarzo-Vysokolan]]></surname>
<given-names><![CDATA[Patricia María Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Ministerio de Salud Pública y Bienestar Social Centro Médico Nacional Hospital Nacional]]></institution>
<addr-line><![CDATA[Itauguá ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>9</volume>
<numero>1</numero>
<fpage>55</fpage>
<lpage>61</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932022000100055&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932022000100055&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932022000100055&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  el índice neutrófilo-linfocito es la relación entre el número absoluto de neutrófilos y linfocitos. Su aumento predice la enfermedad grave por COVID-19, inclusive cuando la inflamación es subclínica.  Objetivo:  determinar la utilidad del índice neutrófilo linfocito como predictor de gravedad de la neumonía a SARS-CoV-2.  Materiales y métodos:  se realizó un estudio de casos y controles, con un muestreo no probabilístico de casos consecutivos de enero a julio de 2021 en pacientes con infección a SARS-CoV-2 del Hospital Nacional, Paraguay. Se consideraron casos a los pacientes con neumonía a SARS-COV-2 grave y controles a aquellos con formas leves y moderadas de neumonía.  Resultados: se incluyeron 310 pacientes (155 casos y 155 controles). La franja etaria estuvo comprendida entre 19 a 90 años (media 53±15 años). La diferencia de índice neutrófilo-linfocito resultó 11,71 en casos vs 7,09 en controles (p 0,0001), teniendo 5,08 veces más probabilidades de desarrollar una neumonía grave los pacientes con índice neutrófilo-linfocito mayor a 3.  Conclusión:  el índice neutrófilo-linfocito predice el desarrollo de una neumonía grave a SARS-CoV-2.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The neutrophil-lymphocyte index is the relationship between the absolute number of neutrophils and lymphocytes. Its increase predicts severe COVID-19 disease, even when inflammation is subclinical.  Objective:  To determine the usefulness of the neutrophil lymphocyte index as a predictor of severity of SARS-CoV-2 pneumonia.  Materials and methods:  A case-control study was carried out, with a non-probabilistic sampling of consecutive cases from January to July 2021 in patients with SARS-CoV-2 infection from the Hospital Nacional, Paraguay. Patients with severe SARS-COV-2 pneumonia and controls were those with mild and moderate forms of pneumonia.  Results:  Three hundred ten patients (155 cases and 155 controls) were included. The age group ranged from 19 to 90 years (mean 53 ± 15 years). The neutrophil-lymphocyte index difference was 11.71 in cases vs 7.09 in controls (p 0.0001), with patients with an neutrophil-lymphocyte index greater than 3 being 5.08 times more likely to develop severe pneumonia.  Conclusion:  neutrophil-lymphocyte index predicts the development of severe pneumonia to SARS-CoV-2.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[infecciones por Coronavirus]]></kwd>
<kwd lng="es"><![CDATA[neutrófilos]]></kwd>
<kwd lng="es"><![CDATA[linfocitos]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[neumonía]]></kwd>
<kwd lng="es"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="en"><![CDATA[Coronavirus infections]]></kwd>
<kwd lng="en"><![CDATA[neutrophils]]></kwd>
<kwd lng="en"><![CDATA[lymphocytes]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[pneumonia]]></kwd>
<kwd lng="en"><![CDATA[SARS-CoV-2]]></kwd>
</kwd-group>
</article-meta>
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