<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932020000100112</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2020.07.01.112-117</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Leucoencefalopatía multifocal progresiva en mujer con SIDA]]></article-title>
<article-title xml:lang="en"><![CDATA[Progressive multifocal leukoencephalopathy in a woman with AIDS]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez Ovelar]]></surname>
<given-names><![CDATA[Roberto Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodas Benítez]]></surname>
<given-names><![CDATA[Karen Yohana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas Benítez]]></surname>
<given-names><![CDATA[Andrea Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escobar Salinas]]></surname>
<given-names><![CDATA[Jorge Sebastián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguayo Uriarte]]></surname>
<given-names><![CDATA[Nicolás Darío]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Central del Instituto de Previsión Social  ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Nacional  ]]></institution>
<addr-line><![CDATA[Itauguá ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<volume>7</volume>
<numero>1</numero>
<fpage>112</fpage>
<lpage>117</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932020000100112&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932020000100112&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932020000100112&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La leucoencefalopatía multifocal progresiva es una de las diversas entidades clínicas con compromiso del sistema nervioso central causada por el virus JC en pacientes con infección por VIH o en algún otro estado de inmunocompromiso. Es una enfermedad sin tratamiento específico efectivo demostrado. Se presenta el caso de una paciente de 33 años de edad con SIDA que desarrolló esta enfermedad con deterioro progresivo del estado general hasta que se produjo su deceso a los 7 días de internación.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Progressive multifocal leukoencephalopathy is one of several clinical entities with compromise of the central nervous system caused by the JC virus in patients with HIV infection or in some other state of immunocompromise. It is a disease without proven effective specific treatment. We present the case of a 33-year-old patient with AIDS who developed this disease with progressive deterioration of the general condition until her death occurred 7 days after hospitalization.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[virus JC]]></kwd>
<kwd lng="es"><![CDATA[síndrome de inmunodeficiencia adquirida]]></kwd>
<kwd lng="es"><![CDATA[leucoencefalopatía multifocal progresiva]]></kwd>
<kwd lng="es"><![CDATA[VIH]]></kwd>
<kwd lng="en"><![CDATA[JC virus]]></kwd>
<kwd lng="en"><![CDATA[acquired immunodeficiency syndrome]]></kwd>
<kwd lng="en"><![CDATA[progressive multifocal leukoencephalopathy]]></kwd>
<kwd lng="en"><![CDATA[human immunodeficiency virus]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lima]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Progressive multifocal leukoencephalopathy]]></article-title>
<source><![CDATA[Arq. Neuropsiquiatr]]></source>
<year>2013</year>
<volume>71</volume>
<numero>9B</numero>
<issue>9B</issue>
<page-range>699-702</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lasso]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Cerón]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Tratamiento conjunto con mirtazapina y terapia antiretroviral para la leucoencefalopatía multifocal progresiva asociada a infección por VIH-1]]></article-title>
<source><![CDATA[Rev. chil. infectol]]></source>
<year>2012</year>
<volume>29</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>217-20</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alcalde López]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández Letamendi]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Lamban Ibor]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Monoparesia en paciente VIH]]></article-title>
<source><![CDATA[Atalaya Médica Turolense]]></source>
<year>2017</year>
<numero>11</numero>
<issue>11</issue>
<page-range>56-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferenczy]]></surname>
<given-names><![CDATA[MW]]></given-names>
</name>
<name>
<surname><![CDATA[Marshall]]></surname>
<given-names><![CDATA[LJ]]></given-names>
</name>
<name>
<surname><![CDATA[Nelson]]></surname>
<given-names><![CDATA[CD]]></given-names>
</name>
<name>
<surname><![CDATA[Atwood]]></surname>
<given-names><![CDATA[WJ]]></given-names>
</name>
<name>
<surname><![CDATA[Nath]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Khalili]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Major]]></surname>
<given-names><![CDATA[EO.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain.]]></article-title>
<source><![CDATA[Clin Microbiol Rev]]></source>
<year>2012</year>
<volume>25</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>471-506</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Piza]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Fink]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Nogueira]]></surname>
<given-names><![CDATA[GS]]></given-names>
</name>
<name>
<surname><![CDATA[Pannuti]]></surname>
<given-names><![CDATA[CS]]></given-names>
</name>
<name>
<surname><![CDATA[Penalva de Oliveira]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
<name>
<surname><![CDATA[Vidal]]></surname>
<given-names><![CDATA[JE.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[JC virus-associated central nervous system diseases in HIV-infected patients in Brazil]]></article-title>
<source><![CDATA[Braz J Infect Dis]]></source>
<year>2012</year>
<volume>16</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>153-6</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gourineni]]></surname>
<given-names><![CDATA[VC]]></given-names>
</name>
<name>
<surname><![CDATA[Juvet]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Bordea]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Sena]]></surname>
<given-names><![CDATA[KN.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Progressive multifocal leukoencephalopathy in a 62-year-old immunocompetent woman.]]></article-title>
<source><![CDATA[Case Rep Neurol Med]]></source>
<year>2014</year>
<volume>2014</volume>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rauer]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Marks]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Urbach]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Warnatz]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Nath]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Holland]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Treatment of progressive multifocal leukoencephalopathy with pembrolizumab.]]></article-title>
<source><![CDATA[N Engl J Med.]]></source>
<year>2019</year>
<volume>380</volume>
<numero>17</numero>
<issue>17</issue>
<page-range>1676-7</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gómez González]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez Gracia]]></surname>
<given-names><![CDATA[MT]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez Iglesias]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Girón González]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Sillero Sánchez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ballester Díaz]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Asencio Marchante]]></surname>
<given-names><![CDATA[JJ.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Leucoencefalopatía multifocal progresiva]]></article-title>
<source><![CDATA[Semin Fund Esp Reumatol]]></source>
<year>2009</year>
<volume>10</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>91-9</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sancho Rubio]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Garijo Gallego]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Villar Yus]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Leucoencefalopatía multifocal progresiva en paciente con diagnóstico tardío de SIDA.]]></article-title>
<source><![CDATA[Rev Clin Med Fam]]></source>
<year>2018</year>
<volume>11</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>176-8</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schwab]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Schneider-Hohendorf]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Melzer]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Cutter]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Wiendl]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Natalizumab-associated PML]]></article-title>
<source><![CDATA[Neurology]]></source>
<year>2017</year>
<volume>88</volume>
<numero>12</numero>
<issue>12</issue>
<page-range>1197-205</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
