<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932018000200045</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2018.05(02)45-052</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Prevalencia de injuria renal aguda en pacientes tratados con colistina]]></article-title>
<article-title xml:lang="en"><![CDATA[Prevalence of acute renal injury in patients treated with colistin]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Gómez]]></surname>
<given-names><![CDATA[Liz Paola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortega Filártiga]]></surname>
<given-names><![CDATA[Edgar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Itapúa. Facultad de Medicina. Postgrado en Medicina Interna.]]></institution>
<addr-line><![CDATA[Encarnación ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Médico Nacional. Hospital Nacional. Dpto. de Medicina Interna.]]></institution>
<addr-line><![CDATA[Itauguá ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2018</year>
</pub-date>
<volume>5</volume>
<numero>2</numero>
<fpage>45</fpage>
<lpage>52</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932018000200045&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932018000200045&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932018000200045&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: la colistina es un antibiótico eficaz para tratar infecciones causadas por bacterias Gram negativas multirresistentes pero tiende a producir injuria renal aguda.  Objetivos:  determinar la frecuencia de injuria renal aguda en pacientes adultos tratados con colistina e identificar la presencia de afecciones comórbidas asociadas.  Metodología:  estudio observacional retrospectivo de pacientes tratados con colistina en el Hospital Nacional, Paraguay, en 2016-2017.  Resultados: se estudiaron 80 pacientes, siendo 64% del sexo masculino. La edad media fue 50±17 años. La prevalencia de injuria renal aguda fue 70%. Según los criterios RIFLE hubo lesión en 45% de los casos, riesgo de lesión en 25% y no riesgo/no lesión en 30%. Las afecciones comórbidas más frecuentes fueron la hipertensión arterial (61%) y diabetes mellitus (31%). El germen aislado con mayor frecuencia fue Acinetobacter baumannii (57%), Pseudomonas aeruginosa (24%) y Klebsiella pneumoniae (19%). Los antibióticos más utilizados en forma combinada con la colistina fueron la vancomicina (46%) y los carbapenémicos (43%).  Conclusiones: la prevalencia de injuria renal aguda fue 70%. Según los criterios RIFLE predominó la lesión. Las afecciones comórbidas más frecuentes fueron la hipertensión arterial y la diabetes mellitus.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Colistin is an effective antibiotic to treat infections caused by multiresistant Gram-negative bacteria but tends to produce acute renal injury.  Objectives: To determine the frequency of acute renal injury in adult patients treated with colistin and to identify the presence of associated comorbid conditions.  Methodology: Retrospective observational study of patients treated with colistin in the National Hospital, Paraguay in 2016-2017.  Results: Eighty patients were studied and 64% of them were male. The mean age was 50±17 years. The prevalence of acute renal injury was 70%. According to the RIFLE criteria there was an injury in 45% of the cases, risk of injury in 25% and no risk/no injury in 30%. The most common comorbid conditions were hypertension (61%) and diabetes mellitus (31%). The most frequently isolated germs were Acinetobacter baumannii (57%), Pseudomonas aeruginosa (24%) and Klebsiella pneumoniae (19%). The most commonly used antibiotics in combination with colistin were vancomycin (46%) and carbapenems (43%).  Conclusions: The prevalence of acute renal injury was 70%. According to the RIFLE criteria, the injury predominated. The most common comorbid conditions were hypertension and diabetes mellitus.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[colistina]]></kwd>
<kwd lng="es"><![CDATA[antibacterianos]]></kwd>
<kwd lng="es"><![CDATA[infecciones por bacterias Gram negativas]]></kwd>
<kwd lng="en"><![CDATA[colistin]]></kwd>
<kwd lng="en"><![CDATA[antibacterials]]></kwd>
<kwd lng="en"><![CDATA[infections by Gram negative bacteria]]></kwd>
</kwd-group>
</article-meta>
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