<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2307-3349</journal-id>
<journal-title><![CDATA[Revista de salud publica del Paraguay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. salud publica Parag.]]></abbrev-journal-title>
<issn>2307-3349</issn>
<publisher>
<publisher-name><![CDATA[INSTITUTO NACIONAL DE SALUD - MSP Y BS]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2307-33492024000300021</article-id>
<article-id pub-id-type="doi">10.18004/rspp.2024.dic.05</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización de la leucocitosis en pacientes con tumores sólidos con y sin proceso infeccioso]]></article-title>
<article-title xml:lang="en"><![CDATA[Characterization of leukocytosis in patients with solid tumors with and without an infectious process]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mallorquín Rabito]]></surname>
<given-names><![CDATA[Juan León]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferreira Maniero]]></surname>
<given-names><![CDATA[Silvia Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Donna]]></surname>
<given-names><![CDATA[María Lucila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morínigo Martínez]]></surname>
<given-names><![CDATA[Macarena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Araujo Pino]]></surname>
<given-names><![CDATA[Silvia Stella]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Ministerio de Salud Pública y Bienestar Social Instituto Nacional del Cáncer Infectología]]></institution>
<addr-line><![CDATA[Capiatá ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Ministerio de Salud Pública y Bienestar Social Instituto Nacional del Cáncer Departamento de Docencia e Investigación]]></institution>
<addr-line><![CDATA[Capiatá ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Ministerio de Salud Pública y Bienestar Social Instituto Nacional de Salud Dirección de Investigación]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>14</volume>
<numero>3</numero>
<fpage>21</fpage>
<lpage>28</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2307-33492024000300021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2307-33492024000300021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2307-33492024000300021&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La leucocitosis en el paciente oncológico con tumores sólidos constituye el segundo motivo de interconsulta y de forma general se indica la antibioticoterapia, si bien la leucocitosis es un signo común de las infecciones, particularmente bacterianas, existen otros estresores capaces de provocar una leucocitosis aguda que incluyen cirugías, ejercicio intenso, traumas, estrés emocional, neoplasias, entre otras, por lo cual la antibioticoterapia no debería generalizarse.  Objetivo:  Caracterizar de la leucocitosis en pacientes con tumores sólidos con y sin proceso infeccioso para quienes se solicitó, de enero de 2021 a agosto de 2023, interconsulta con Infectología del Instituto Nacional del Cáncer.  Materiales y métodos:  Diseño descriptivo, observacional, de corte transversal, con datos secundarios. Se procesaron datos de 144 casos de pacientes internados diagnosticados con tumores sólidos oncológicos o en espera de resultados confirmatorios, que solicitaron interconsulta con el especialista en infectología por presencia de leucocitosis en el hemograma en ausencia de clínica infecciosa o persistencia de la leucocitosis a pesar de un tratamiento antibiótico exitoso según parámetros clínicos. Se empleó la estadística descriptiva para el procesamiento de datos y se contó con aprobación del Comité de Ética del INCAN.  Resultado:  De los 144 pacientes, 44 (30,5%) presentaron algún proceso infeccioso evidenciable por clínica o métodos diagnósticos auxiliares. En 100 pacientes, (69,5%) no pudo evidenciarse la presencia de proceso infeccioso alguno con base en parámetros clínicos y métodos auxiliares diagnósticos. El fenómeno de leucocitosis y neutrofilia se observó en todos los casos en ambos grupos de pacientes, aun después del tratamiento con antibióticos en aquellos que lo precisaron. La trombocitosis se observó en 23/100 pacientes sin diagnóstico infeccioso (23%), versus 23/44 (52,2%) pacientes con proceso infeccioso activo.  Conclusión:  La reactividad leucocitaria es un fenómeno hematológico común en los procesos neoplásicos y persiste aún después de un tratamiento antibiótico exitoso. Los procesos infecciosos fueron evidentes, específicos, diversos y sin predominio significativo de alguna entidad en particular por lo que la antibioticoterapia empírica debe ser postergada.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Leukocytosis in cancer patients with solid tumors is the second reason for consultation and antibiotic therapy is generally indicated. However, if leukocytosis is a common sign of infections, particularly bacterial, there are other stressors capable of causing an acute leukocytosis that include surgeries, intense exercise, trauma, emotional stress, neoplasms, among others, which is why antibiotic therapy should not be generalized.  Objective:  To characterize leukocytosis in patients with solid tumors with and without an infectious process who attended from January 2021 to August 2023 for consultation with infectology of the National Cancer Institute.  Materials and methods:  descriptive, observational, cross-sectional design, with secondary data. Data were processed from 144 cases of hospitalized patients diagnosed with solid oncological tumors or awaiting confirmatory results, who requested consultation with the infectious disease specialist due to the presence of leukocytosis in the blood count in the absence of infectious symptoms or persistence of leukocytosis despite a successful antibiotic treatment. Descriptive statistics were used for data processing and approval was obtained from the INCAN Ethics Committee.  Result:  Of the 144 patients, 44 (30.5%) presented some infectious process evident by clinical or auxiliary diagnostic methods. In 100 patients (69.5%) the presence of any infectious process could not be evidenced based on clinical parameters and auxiliary diagnostic methods. The phenomenon of leukocytosis and neutrophilia was observed in all cases in both groups of patients, even after antibiotic treatment in those who presented it. Thrombocytosis was observed in 23/100 patients without an infectious diagnosis (23%), versus 23/44 (52.2%) patients with an active infectious process.  Conclusion:  Leukocyte reactivity is a common hematological phenomenon in neoplastic processes and persists even after successful antibiotic treatment. The infectious processes were evident, specific, diverse and without significant predominance of any particular entity, so empirical antibiotic therapy should be postponed.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[leucocitosis]]></kwd>
<kwd lng="es"><![CDATA[trombocitosis]]></kwd>
<kwd lng="es"><![CDATA[cáncer]]></kwd>
<kwd lng="es"><![CDATA[neoplasia]]></kwd>
<kwd lng="es"><![CDATA[infección]]></kwd>
<kwd lng="en"><![CDATA[leukocytosis]]></kwd>
<kwd lng="en"><![CDATA[thrombocytosis]]></kwd>
<kwd lng="en"><![CDATA[cancer]]></kwd>
<kwd lng="en"><![CDATA[neoplasia]]></kwd>
<kwd lng="en"><![CDATA[infection]]></kwd>
</kwd-group>
</article-meta>
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