<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2222-145X</journal-id>
<journal-title><![CDATA[Reportes científicos de la FACEN]]></journal-title>
<abbrev-journal-title><![CDATA[Rep. cient. FACEN]]></abbrev-journal-title>
<issn>2222-145X</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Ciencias Exactas y Naturales]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2222-145X2025000100026</article-id>
<article-id pub-id-type="doi">10.18004/rcfacen.2025.16.1.026</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Análisis comparativo estructural de la secuencia pseudo-NLS de las importinas &#945; y el dominio C-terminal de las proteínas ORF6 del SARS-CoV-2 y SARS-CoV]]></article-title>
<article-title xml:lang="en"><![CDATA[Comparative structural analysis of pseudo-NLS sequence of importins &#945; and C-terminal domain of ORF6 proteins of SARS-CoV-2 and SARS-CoV]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gayozo]]></surname>
<given-names><![CDATA[Elvio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas]]></surname>
<given-names><![CDATA[Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alvarez]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Exactas y Naturales Departamento de Biología, Laboratorio de Mutagénesis, Carcinogénesis y Teratogénesis Ambiental]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Químicas Departamento de Microbiología Industrial]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Autónoma Metropolitana Campus Xochimilco Departamento El Hombre y su Ambiente ]]></institution>
<addr-line><![CDATA[Ciudad de México ]]></addr-line>
<country>México</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>16</volume>
<numero>1</numero>
<fpage>26</fpage>
<lpage>40</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2222-145X2025000100026&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2222-145X2025000100026&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2222-145X2025000100026&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: La proteína ORF6 (P6) del SARS-CoV-2 y SARS-CoV tiene la función principal de bloquear la respuesta antiviral en las células infectadas. Estudios revelaron la ausencia de secuencias NLS (señal de localización nuclear) canónicas en la P6, por lo que el posible mecanismo de interacción entre las P6 y las importinas &#945; no queda claro aún, sin embargo, parecen compartir ciertas características con la secuencia pseudo-NLS de las importinas &#945;. El objetivo principal de este estudio fue analizar estructuralmente las semejanzas existentes entre las secuencias del dominio C-terminal de la P6 y la secuencia pseudo-NLS de las importinas &#945;, mediante un análisis computacional del acoplamiento molecular entre estas proteínas y la autoinhibición de la importina &#945;. Para ello, se realizó el alineamiento entre secuencias de la P6 y la secuencia pseudo-NLS de la importina &#945;, seguidamente se procedió llevar a cabo el modelado de estas proteínas y realizar pruebas de acoplamiento molecular entre la P6 (SARS-CoV-2 y SARS-CoV) y la importina &#945;, así como simular la autoinhibición de la importina &#945;. Los datos obtenidos evidenciaron una similitud del 54,5% entre estas secuencias, las simulaciones de acoplamiento molecular revelaron valores de energía libre de unión favorables. El análisis de los complejos reveló que comparten afinidades por los mismos dominios ARM en las importinas &#945; y mismos residuos activos en un 50% en el caso de la P6 del SARS-CoV-2, esto podría sugerir que estas secuencias virales podrían presentar propiedades fisicoquímicas semejantes a las de la secuencia pseudo-NLS de la misma importina &#945;.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: The ORF6 (P6) protein of SARS-CoV-2 and SARS-CoV has the main function of blocking the antiviral response in infected cells. Studies revealed the absence of canonical NLS (nuclear localization signal) sequences in P6, so the possible mechanism of interaction between P6 and importins &#945; is still unclear, however, they seem to share certain features with the pseudo-NLS sequence of importins &#945;. The main objective of this study was to structurally analyze the similarities existing between the sequences of the C-terminal domain of P6 and the pseudo-NLS sequence of &#945;-importins, by means of a computational analysis of the molecular coupling between these proteins and importin &#945; autoinhibition. For this purpose, the alignment between P6 sequences and pseudo-NLS sequence of importin &#945; was performed, followed by molecular modeling of these proteins and molecular docking simulations between P6 (SARS-CoV-2 and SARS-CoV) and importin &#945;, as well as importin &#945; autoinhibition. The data obtained evidenced a 54.5% similarity between these sequences, molecular docking simulations revealed favorable binding free energy value. The analysis of complexes revealed that they share affinities to the same ARM domains in importins &#945; and same active residues, approximately 50% in the case of P6 of SARS-CoV-2, this suggest that these viral sequences could present a similar physicochemical property to those of the pseudo-NLS sequence of the importin &#945;.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ORF6]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[Carioferinas]]></kwd>
<kwd lng="es"><![CDATA[2019-nCoV]]></kwd>
<kwd lng="es"><![CDATA[acoplamiento molecular]]></kwd>
<kwd lng="en"><![CDATA[ORF6]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[Karyopherins]]></kwd>
<kwd lng="en"><![CDATA[2019-nCoV]]></kwd>
<kwd lng="en"><![CDATA[molecular docking]]></kwd>
</kwd-group>
</article-meta>
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