<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2222-145X</journal-id>
<journal-title><![CDATA[Reportes científicos de la FACEN]]></journal-title>
<abbrev-journal-title><![CDATA[Rep. cient. FACEN]]></abbrev-journal-title>
<issn>2222-145X</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Ciencias Exactas y Naturales]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2222-145X2022000100041</article-id>
<article-id pub-id-type="doi">10.18004/rcfacen.2022.13.1.41</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación mutagénica de tres herbicidas a base de glifosato empleando el test de mutación y recombinación somática en Drosophila melanogaster]]></article-title>
<article-title xml:lang="en"><![CDATA[Mutagenic evaluation of three glyphosate-based herbicides using somatic mutation and recombination test in Drosophila melanogaster]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marín Insfrán]]></surname>
<given-names><![CDATA[Luis Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gayozo Melgarejo]]></surname>
<given-names><![CDATA[Elvio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rivarola Sena]]></surname>
<given-names><![CDATA[Cynthia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Núñez]]></surname>
<given-names><![CDATA[Clara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Exactas y Naturales Departamento de Biología, Laboratorio de Mutagénesis, Carcinogénesis y Teratogénesis Ambiental]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>13</volume>
<numero>1</numero>
<fpage>41</fpage>
<lpage>50</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2222-145X2022000100041&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2222-145X2022000100041&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2222-145X2022000100041&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: En zonas rurales de Paraguay los herbicidas son ampliamente utilizados, entre los cuales se encuentran un gran número que son elaborados a base de glifosato, estos actúan inhibiendo la actividad de enzimas que sintetizan aminoácidos aromáticos en las plantas. Estudios han demostrado que no poseen actividad geno- tóxica, sin embargo, otras investigaciones indican lo contrario. Esta investigación tiene por objetivo principal evaluar la actividad mutagénica de tres herbicidas a base de glifosato (formulación comercial) en Drosophila melanogaster mediante el ensayo SMART. El diseño del estudio fue de bloques al azar, donde se trataron larvas de D. melanogaster tanto en cruce estándar y en cruce de alta bioactivación por 72±5 horas con diferentes concentraciones de los tres herbicidas a base de glifosato (0,01, 0,1, 1 y 10 mg.mL-1), como agente mutágeno se empleó Ciclofosfamida a concentraciones de 2,61 y 0,78 mg.mL-1, como testigo agua destilada. Los resultados obtenidos no fueron estadísticamente significativos, sin embargo, el herbicida GBH2 a la concentración de 10 mg.mL-1 evidenció un aumento significativo de clones mutantes del tipo mancha simple pequeña y en el total de mutaciones en comparación al testigo empleado.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: In rural areas of Paraguay are widely used herbicides, among which several are made of glyphosate, these are systemic broad spectrum and act by inhibiting the activity of enzymes that synthesize aromatic aminoacids in plants. Studies have shown that they don&#8217;t have genotoxic activity, however, other research indicates that they can alter cellular processes in animals, which can present an environmental and health risk factor. The main objective of this work is to evaluate the mutagenic activity of three glyphosate-based herbicides (commercial formulation) in Drosophila melanogaster through SMART assay. For this, third stage larvae of D. melanogaster obtained from standard crossing and high bioactivation cross were chronically treated orally for 72 ± 5 hours with different concentrations (0.01, 0.1, 1 and 10 mg.mL-1) of three glyphosate-based herbicides, Cyclophosphamide 2.61 and 0.78 mg.mL-1 were used as a mutagenic agent and as a control distilled water. The results obtained were not statistically significant, however, the herbicide GBH2 at the concentration of 10 mg.mL-1 showed significant differences compared to control in mutations number of small single spot type and total number of mutations observed.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[SMART]]></kwd>
<kwd lng="es"><![CDATA[herbicidas a base de glifosato]]></kwd>
<kwd lng="es"><![CDATA[Drosophila melanogaster]]></kwd>
<kwd lng="es"><![CDATA[mutagenicidad]]></kwd>
<kwd lng="en"><![CDATA[SMART]]></kwd>
<kwd lng="en"><![CDATA[glyphosate-based herbicides]]></kwd>
<kwd lng="en"><![CDATA[Drosophila melanogaster]]></kwd>
<kwd lng="en"><![CDATA[mutagenicity]]></kwd>
</kwd-group>
</article-meta>
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