<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2072-8174</journal-id>
<journal-title><![CDATA[Revista del Nacional (Itauguá)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Nac. (Itauguá)]]></abbrev-journal-title>
<issn>2072-8174</issn>
<publisher>
<publisher-name><![CDATA[Hospital Nacional (Itauguá)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2072-81742026000100302</article-id>
<article-id pub-id-type="doi">10.18004/rdn2026.e1800202</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Carcinoma epidermoide desarrollado sobre un quiste epidérmico]]></article-title>
<article-title xml:lang="en"><![CDATA[Squamous cell carcinoma developed on an epidermal cyst]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández Gómez]]></surname>
<given-names><![CDATA[Pamela Verónica]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Ayala]]></surname>
<given-names><![CDATA[Cándida Isolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Ayala]]></surname>
<given-names><![CDATA[Sergio David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soskin Reidman]]></surname>
<given-names><![CDATA[Ana Esther]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Ministerio de Salud Pública y Bienestar Social Hospital General de Itapúa &#8220;Ladislao HrisukSzulek&#8221; Servicio de Anatomía Patológica]]></institution>
<addr-line><![CDATA[Itapúa ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Cátedra de Anatomía Patológica e Histología]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Columbia del Paraguay Escuela de Gobierno Sede Posgrado Columbia, Dirección de Investigación y Extensión]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Ministerio de Salud Pública y Bienestar Social Centro Médico Nacional-Hospital Nacional Servicio de Anatomía Patológica]]></institution>
<addr-line><![CDATA[Itauguá ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<volume>18</volume>
<fpage>302</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2072-81742026000100302&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2072-81742026000100302&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2072-81742026000100302&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El carcinoma epidermoide desarrollado sobre un quiste epidérmico constituye una entidad extremadamente infrecuente, con una incidencia estimada menor al 0,05% de los casos. Presentamos el caso de un paciente masculino de 22 años con una lesión cutánea en la región antero-interna del muslo derecho, clínicamente interpretada como quiste epidérmico complicado, cuyo estudio histológico reveló áreas de transición hacia carcinoma epidermoide bien diferenciado. El paciente evolucionó favorablemente tras la resección completa, sin evidencia de recurrencia en el seguimiento a dos meses. A través de la revisión de la literatura mundial, se analizan los factores predisponentes, los criterios diagnósticos y las implicancias terapéuticas. Se resalta la importancia del estudio histopatológico de todas las piezas quirúrgicas, así como la necesidad de difundir nuevos casos en la región, con el fin de aumentar la conciencia clínica y anatomopatológica y aportar al conocimiento científico global.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Squamous cell carcinoma developing in an epidermal cyst is an extremely rare entity, with an estimated incidence of less than 0.05% of cases. We present the case of a 22-year-old male with a cutaneous lesion located in the anteromedial region of the right thigh, clinically interpreted as a complicated epidermal cyst, whose histological study revealed transition areas toward well-differentiated squamous cell carcinoma. The patient evolved favorably after complete resection, with no evidence of recurrence at two-month follow-up. Through a review of the international literature, we analyze predisposing factors, diagnostic criteria, and therapeutic implications. This case emphasizes the importance of histopathological examination of all surgical specimens, as well as the need to report new cases in the region to raise clinical and pathological awareness and contribute to global scientific knowledge.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[carcinoma epidermoide]]></kwd>
<kwd lng="es"><![CDATA[quiste epidermoide]]></kwd>
<kwd lng="es"><![CDATA[transformación neoplásica maligna]]></kwd>
<kwd lng="es"><![CDATA[anatomía patológica]]></kwd>
<kwd lng="es"><![CDATA[informes de casos]]></kwd>
<kwd lng="en"><![CDATA[squamous cell carcinoma]]></kwd>
<kwd lng="en"><![CDATA[epidermal cyst]]></kwd>
<kwd lng="en"><![CDATA[malignant transformation]]></kwd>
<kwd lng="en"><![CDATA[pathology]]></kwd>
<kwd lng="en"><![CDATA[anatomical]]></kwd>
<kwd lng="en"><![CDATA[case reports.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[JY]]></given-names>
</name>
<name>
<surname><![CDATA[Min]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[JKH]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[SW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Squamous cell carcinoma arising from epidermal cyst: a case series of 9 patients with a literatura review]]></article-title>
<source><![CDATA[Ann Plast Surg]]></source>
<year>2024</year>
<volume>92</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>575-9</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Choi]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[JK]]></given-names>
</name>
<name>
<surname><![CDATA[Song]]></surname>
<given-names><![CDATA[SG]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Next-generation sequencing study on poorly differentiated carcinoma derived from a thirty-year-old epidermoid cyst: a case report]]></article-title>
<source><![CDATA[Front Oncol]]></source>
<year>2023</year>
<volume>13</volume>
<page-range>1017624</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Griffin]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Griffin]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[SD]]></given-names>
</name>
<name>
<surname><![CDATA[Polansky]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Stage T3 squamous cell carcinoma misdiagnosed as anepidermal inclusión cyst]]></article-title>
<source><![CDATA[Dermatol Surg]]></source>
<year>2022</year>
<volume>48</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1108-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jeon]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[SY]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[US]]></given-names>
</name>
<name>
<surname><![CDATA[Kwon]]></surname>
<given-names><![CDATA[ST]]></given-names>
</name>
<name>
<surname><![CDATA[Kwak]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinicopathologic features of epidermoid cysts in the upper and lower extremities, including a case of malignant transformation in thepalmoplantarregion]]></article-title>
<source><![CDATA[Arch Hand Microsurg]]></source>
<year>2022</year>
<volume>27</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>285-91</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Frank]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Macias]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Hondorp]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Kerstetter]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Inman]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Incidental squamous cell carcinoma in an epidermal inclusión cyst: a case report and review of the literature]]></article-title>
<source><![CDATA[Case Rep Dermatol]]></source>
<year>2018</year>
<volume>10</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>61-8</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[BS]]></given-names>
</name>
<name>
<surname><![CDATA[Shin]]></surname>
<given-names><![CDATA[DH]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
<name>
<surname><![CDATA[Jung]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
<name>
<surname><![CDATA[Son]]></surname>
<given-names><![CDATA[GM]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[HS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Perineal squamous cell carcinoma arising from an epidermal cyst: a case report]]></article-title>
<source><![CDATA[World J Surg Oncol]]></source>
<year>2018</year>
<volume>16</volume>
<page-range>155</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Morritt]]></surname>
<given-names><![CDATA[AN]]></given-names>
</name>
<name>
<surname><![CDATA[Tiffin]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Brotherston]]></surname>
<given-names><![CDATA[TM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Squamous cell carcinoma arising in epidermoid cysts: report of four cases and review of the literature]]></article-title>
<source><![CDATA[J Plast Reconstr Aesthet Surg]]></source>
<year>2012</year>
<volume>65</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>1267-9</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Antón-Badiola]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[San Miguel-Fraile]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Peteiro-Cancelo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ortiz-Rey]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Squamous cell carcinoma arising on an epidermal inclusión cyst: a case presentation and review of the literature]]></article-title>
<source><![CDATA[Actas Dermosifiliogr]]></source>
<year>2010</year>
<volume>101</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>349-53</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ziadi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Trimeche]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Hammedi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Sriha]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Jomaa]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Mokni]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Squamous cell carcinoma arising from an epidermal inclusión cyst: a case report]]></article-title>
<source><![CDATA[N Am J Med Sci]]></source>
<year>2010</year>
<volume>2</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>46-7</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shabbir]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Loss]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bogner]]></surname>
<given-names><![CDATA[PN]]></given-names>
</name>
<name>
<surname><![CDATA[Zeitouni]]></surname>
<given-names><![CDATA[NC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Squamous cell carcinoma developing from an epidermoid cyst of the ear]]></article-title>
<source><![CDATA[Dermatol Surg]]></source>
<year>2011</year>
<volume>37</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>700-3</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Heo]]></surname>
<given-names><![CDATA[TG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Squamous cell carcinoma arising from a huge buttock epidermal cyst without skin lesion: a case report]]></article-title>
<source><![CDATA[Int J Surg Case Rep]]></source>
<year>2023</year>
<volume>102</volume>
<page-range>107850</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[CC]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[YY]]></given-names>
</name>
<name>
<surname><![CDATA[Ho]]></surname>
<given-names><![CDATA[YY]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Squamous cell carcinoma arising in a verrucous cyst-likelesion: a case report]]></article-title>
<source><![CDATA[Dermatol Sin]]></source>
<year>2021</year>
<volume>39</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>151-2</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rai]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Thacker]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bhatti]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Arora]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A rare twist: malignant transformation of epidermal cysts in the submandibular gland-a case report and literaturereview]]></article-title>
<source><![CDATA[Medical Reports]]></source>
<year>2025</year>
<volume>10</volume>
<page-range>100180</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yamanaka]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Llamosas]]></surname>
<given-names><![CDATA[BF]]></given-names>
</name>
<name>
<surname><![CDATA[Adorno]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Quiste epidermoide del ciego]]></article-title>
<source><![CDATA[Rev Chil Cir]]></source>
<year>2012</year>
<volume>64</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>79-82</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Di Martino Ortiz]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Claves para el diagnóstico dermatopatológico de los quistes cutáneos]]></article-title>
<source><![CDATA[Our Dermatol Online]]></source>
<year>2013</year>
<volume>4</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>230-6</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
