<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2072-8174</journal-id>
<journal-title><![CDATA[Revista del Nacional (Itauguá)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Nac. (Itauguá)]]></abbrev-journal-title>
<issn>2072-8174</issn>
<publisher>
<publisher-name><![CDATA[Hospital Nacional (Itauguá)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2072-81742026000100301</article-id>
<article-id pub-id-type="doi">10.18004/rdn2026.e1800201</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de Edwards: reporte de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Edwards syndrome: case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Prieto Agüero]]></surname>
<given-names><![CDATA[María Magdalena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Godoy López]]></surname>
<given-names><![CDATA[Sandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Caballero Portillo]]></surname>
<given-names><![CDATA[Belén Ramona]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Ministerio de Salud Pública y Bienestar Social Centro Médico Nacional-Hospital Nacional Departamento de Ginecología-Obstetricia]]></institution>
<addr-line><![CDATA[Itauguá ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Itapuá Facultad de Medicina Posgrado en Ginecología y Obstetricia]]></institution>
<addr-line><![CDATA[Encarnación ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<volume>18</volume>
<fpage>301</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2072-81742026000100301&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2072-81742026000100301&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2072-81742026000100301&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El Sindrome de Edwards es un trastorno autosómico que se caracteriza por múltiples malformaciones entre ellas craneofaciales, toracoabdominales, en extremidades, piel y faneras incluye además trastornos neurológicos, cardiacos, pulmonares y de otros órganos internos además de retardo del crecimiento. Este síndrome se caracteriza por la presencia de 3 cromosomas en el par del cromosoma 18 y es la segunda enfermedad cromosómica más frecuente después de la trisomía 21. Presentamos un caso clínico que se encuentra basado en el diagnóstico clínico prenatal presuntivo debido a que no disponemos con técnicas de diagnóstico genético. El recién nacido presentaba la mayoría de las anomalías descritas para dicha patología lo que nos permitió sostener el diagnóstico clínico. El objetivo se basa en la importancia del diagnóstico prenatal oportuno mediante las técnicas de imágenes más accesibles como lo es la ecografía y la necesidad de contar con un equipo multidisciplinario con cobertura integral para las familias.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Edwards syndrome is an autosomal disorder characterized by multiple malformations, including craniofacial, thoracoabdominal, limb, skin, and appendage anomalies. It also involves neurological, cardiac, pulmonary, and other internal organ abnormalities, in addition to growth retardation. This syndrome is caused by the presence of three chromosomes in pair 18 and is the second most common chromosomal disease after trisomy 21. We present a clinical case based on a presumptive prenatal clinical diagnosis, as genetic diagnostic techniques were not available. The newborn exhibited most of the anomalies described for this condition, which allowed us to support the clinical diagnosis. The objective is to highlight the importance of timely prenatal diagnosis using the most accessible imaging techniques, such as ultrasound, and the need for a multidisciplinary team that provides comprehensive support to families.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[trisomía]]></kwd>
<kwd lng="es"><![CDATA[malformaciones]]></kwd>
<kwd lng="es"><![CDATA[síndrome]]></kwd>
<kwd lng="en"><![CDATA[trisomy]]></kwd>
<kwd lng="en"><![CDATA[malformations]]></kwd>
<kwd lng="en"><![CDATA[syndrome.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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