<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2072-8174</journal-id>
<journal-title><![CDATA[Revista del Nacional (Itauguá)]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Nac. (Itauguá)]]></abbrev-journal-title>
<issn>2072-8174</issn>
<publisher>
<publisher-name><![CDATA[Hospital Nacional (Itauguá)]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2072-81742025000100203</article-id>
<article-id pub-id-type="doi">10.18004/rdn2025.e1700203</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome mano-pie posterior a uso de Doxorrubicina]]></article-title>
<article-title xml:lang="en"><![CDATA[Hand-foot syndrome after use of Doxorubicin]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montiel Centurión]]></surname>
<given-names><![CDATA[Judith Nelsi]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Da Ponte Rojas]]></surname>
<given-names><![CDATA[María Noemí]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Contreras Ramírez]]></surname>
<given-names><![CDATA[Claudia Romina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Goiburú Chenú]]></surname>
<given-names><![CDATA[María Belén]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aldama Caballero]]></surname>
<given-names><![CDATA[Arnaldo Benjamín Feliciano]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Hospital de Clínicas]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Ministerio de Salud Pública y Bienestar Social Centro Médico Nacional-Hospital Nacional Departamento de Medicina Interna, Servicio de Dermatología]]></institution>
<addr-line><![CDATA[Itauguá ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>17</volume>
<fpage>203</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2072-81742025000100203&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2072-81742025000100203&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2072-81742025000100203&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El síndrome mano-pie (SMP), también llamado eritrodisestesia palmoplantar, constituye una toxicidad cutánea dosis-dependiente asociada a numerosos antineoplásicos citotóxicos y algunas terapias dirigidas. Su incidencia varía entre 6 y 64 %, siendo capecitabina y la doxorrubicina liposomalpegilada los fármacos más implicados. La patogenia combina citotoxicidad directa sobre queratinocitos y glándulas ecrinas de palmas y plantas, áreas ricas en microvasculatura y sometidas a presión mecánica. Clínicamente se inicia con disestesias que progresan a eritema bien delimitado, edema y descamación; los criterios CTCAE ayudan a graduar la severidad y a decidir ajustes de dosis. El manejo integra profilaxis (emolientes, enfriamiento regional) y tratamiento sintomático con corticoides tópicos de alta potencia, analgésicos y queratolíticos; los cuadros graves pueden requerir reducción o diferimiento de la quimioterapia para preservar la calidad de vida y la continuidad terapéutica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Hand-foot syndrome (HFS) , also known as palmar-plantar erythrodysesthesia, is a dose-dependent cutaneous toxicity associated with numerous cytotoxic antineoplastic agents and some targeted therapies. Its incidence ranges from 6% to 64%, with capecitabine and pegylated liposomal doxorubicin being the most frequently implicated drugs. The pathogenesis combines direct cytotoxicity on keratinocytes and eccrine glands of the palms and soles, areas rich in microvasculature and subject to mechanical pressure. Clinically, it begins with dysesthesias that progress to well-defined erythema, edema, and scaling; CTCAE criteria help grade severity and determine dose adjustments. Management integrates prophylaxis (emollients, regional cooling) and symptomatic treatment with high-potency topical corticosteroids, analgesics, and keratolytics. Severe cases may require reduction or deferral of chemotherapy to preserve quality of life and therapeutic continuity.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[doxorrubicina]]></kwd>
<kwd lng="es"><![CDATA[Síndrome Mano-Pie]]></kwd>
<kwd lng="es"><![CDATA[Neoplasias Ovarianas]]></kwd>
<kwd lng="en"><![CDATA[Doxorubicin]]></kwd>
<kwd lng="en"><![CDATA[Hand-FootSyndrome]]></kwd>
<kwd lng="en"><![CDATA[OvarianNeoplasms.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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