<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1996-3696</journal-id>
<journal-title><![CDATA[Revista del Instituto de Medicina Tropical]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Inst. Med. Trop.]]></abbrev-journal-title>
<issn>1996-3696</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Medicina Tropical]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1996-36962025000100008</article-id>
<article-id pub-id-type="doi">10.18004/imt/2025.20.1.8</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Leishmaniasis visceral en pacientes hospitalizados: experiencia en un hospital de referencia en Paraguay]]></article-title>
<article-title xml:lang="en"><![CDATA[Visceral leishmaniasis in hospitalized patients: experience in a referral hospital in Paraguay]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuellar]]></surname>
<given-names><![CDATA[Gustavo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ovando]]></surname>
<given-names><![CDATA[Fátima]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez de Cuellar]]></surname>
<given-names><![CDATA[Celia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Departamento de Infectología]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2025</year>
</pub-date>
<volume>20</volume>
<numero>1</numero>
<fpage>8</fpage>
<lpage>14</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1996-36962025000100008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1996-36962025000100008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1996-36962025000100008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La Leishmaniasis constituye una enfermedad emergente de impacto mundial, con 12 millones de personas infectadas, y más de 2 millones de casos nuevos por año. En Paraguay, en el 2022 se identificaron 69 casos, 19% más que en 2021 (58 casos); en el 2023, 9 casos hasta la semana epidemiológica 5. El objetivo fue determinar las características clínicas y evolutivas de pacientes internados con Leishmaniasis visceral en el Hospital de Clínicas. Material y métodos: Trabajo retrospectivo de corte transversal, observacional, descriptivo, de pacientes internados entre los años 2012 y 2023 con diagnóstico de Leishmaniasis visceral. Resultados: se reporta las características clínicas, evolutivas, tratamiento y evolución de 12 pacientes con diagnóstico de Leishmaniasis visceral internados en el hospital de Clínicas en el periodo 2012 - 2023. La edad media fue de 42,9±14 años; 10/12 de sexo masculino. El tiempo transcurrido entre el inicio de los síntomas y el diagnóstico fue de 96,6±102,4 días. Todos refirieron fiebre y palidez. Todos presentaron anemia y la mayoría leucopenia y plaquetopenia. El diagnóstico se realizó por detección del Ag RK-39 (8/12) y detección del parásito en médula ósea (6/12). Se realizó tratamiento con Anfotericina o Glucantime, con buena evolución en 11 pacientes, 1 falleció, quien presentó una evolución previa al diagnóstico de 9 meses. Conclusión: La fiebre fue un síntoma observado en todos los pacientes. Todos los pacientes presentaron anemia, la leucopenia y plaquetopenia se observó en la mayoría de los pacientes al igual que la esplenomegalia y hepatomegalia. El tiempo de evolución de la enfermedad fue prolongado pudiendo determinar el desenlace fatal en un paciente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Leishmaniasis constitutes an emerging disease of global impact, with 12 million infected individuals and more than 2 million new cases annually. In Paraguay, 69 cases were identified in 2022, representing a 19% increase compared to 2021 (58 cases); in 2023, 9 cases were reported by epidemiological week 5. The objective was to determine the clinical and evolutionary characteristics of patients hospitalized with visceral leishmaniasis at the Hospital de Clínicas. Materials and Methods: Retrospective, cross-sectional, observational, descriptive study of patients hospitalized between 2012 and 2023 with a diagnosis of visceral leishmaniasis. Results: We report the clinical characteristics, evolution, treatment, and outcomes of 12 patients diagnosed with visceral leishmaniasis hospitalized at the Hospital de Clínicas during the period 2012-2023. The mean age was 42.9±14 years; 10/12 were male. The time elapsed between symptom onset and diagnosis was 96.6±102.4 days. All patients presented with fever and pallor. All exhibited anemia, and the majority had leukopenia and thrombocytopenia. Diagnosis was established through RK-39 antigen detection (8/12) and parasite identification in bone marrow (6/12). Treatment was administered with Amphotericin B or Glucantime, with favorable evolution in 11 patients; one patient died, who had experienced a 9-month evolution prior to diagnosis. Conclusion: Fever was a symptom observed in all patients. All patients presented anemia, while leukopenia and thrombocytopenia were observed in the majority of patients, as were splenomegaly and hepatomegaly. The disease evolution time was prolonged, potentially determining the fatal outcome in one patient.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Leishmaniasis visceral, signos y síntomas, hospitalización]]></kwd>
<kwd lng="es"><![CDATA[Agentes antiprotozoarios]]></kwd>
<kwd lng="es"><![CDATA[Anfotericina B]]></kwd>
<kwd lng="en"><![CDATA[Leishmaniasis visceral, signs and symptoms, hospitalization]]></kwd>
<kwd lng="en"><![CDATA[antiprotozoal agents]]></kwd>
<kwd lng="en"><![CDATA[Amphotericin B]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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