<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1996-3696</journal-id>
<journal-title><![CDATA[Revista del Instituto de Medicina Tropical]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Inst. Med. Trop.]]></abbrev-journal-title>
<issn>1996-3696</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Medicina Tropical]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1996-36962022000200004</article-id>
<article-id pub-id-type="doi">10.18004/imt/2022.17.2.2</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Microorganismos productores de carbapenemasa en muestras clínicas de pacientes internados en el hospital de clínicas durante los años 2020-2021.]]></article-title>
<article-title xml:lang="en"><![CDATA[Carbapenemase-producing microorganisms in clinical samples of inpatients of Hospital de Clínicas during the years 2020-2021]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Riquelme]]></surname>
<given-names><![CDATA[Irma]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guerin]]></surname>
<given-names><![CDATA[Rebeca]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cabral]]></surname>
<given-names><![CDATA[Isidro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zubeldia]]></surname>
<given-names><![CDATA[Ana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ovando]]></surname>
<given-names><![CDATA[Fátima]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortellado]]></surname>
<given-names><![CDATA[Juana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,San Lorenzo  ]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>17</volume>
<numero>2</numero>
<fpage>4</fpage>
<lpage>12</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1996-36962022000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1996-36962022000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1996-36962022000200004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La Organización Mundial de la Salud ha declarado que la resistencia a los antimicrobianos es una de las 10 principales amenazas de salud pública a las que se enfrenta la humanidad. Actualmente, enzimas de las familias Klebsiella pneumoniae carbapenemase (KPC), Oxacillinase (OXA), New Delhi Metallo-beta-lactamase (NDM), Verona Integron En coded Metallo-beta-lactamase (VIM) e Imipenemase (IMP) son las que se detectan con mayor frecuencia a nivel mundial. El objetivo es describir los hallazgos de los aislamientos de microorganismos productores de carbapenemasas de pacientes internados en el Hospital de Clínicas durante los años 2020 y 2021. Se realizó un estudio descriptivo retrospectivo de corte transversal de datos obtenidos del laboratorio de microbiología del Hospital entre enero 2020 y diciembre 2021. Se estudiaron 216 muestras clínicas de las cuales 196(91%) fueron en pacientes adultos, 172 (80%) fueron positivos para enzimas metalo-&#946;-lactamasa (MBL), Klebsiella pneumoniae fue la especie más frecuente. En pacientes internados en la Unidad de Cuidados Intensivos predominaron estos aislamientos y en muestras de orina 91 (42%). Según sexo, 108(50%) para ambos sexos y una mediana de edad de 52 años, con un rango de 6 días de vida a 92 años. En cuanto a número de aislamientos hallados, fue mayor en el año 2020 con 121 (56%).La vigilancia activa junto a medidas de control de infecciones son necesarias para limitar la diseminación de microorganismos productores de carbapenemasas, además se hallan datos necesarios para justificar la introducción al país de antibióticos de elección para estos microorganismos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The World Health Organization has declared antimicrobial resistance one of the top 10 public health threats facing humanity. Currently, enzymes from the families Klebsiella pneumoniae carbapenemase (KPC), Oxacillinase (OXA), New Delhi Metallo-beta-lactamase (NDM), Verona Integron En coded Metallo-beta-lactamase (VIM) and Imipenemase (IMP) are those that are more frequently detected worldwide. The objective is to describe the findings of the isolates of carbapenemase-producing microorganisms from patients hospitalized at the Hospital de Clínicas during the years 2020 and 2021. A retrospective descriptive cross-sectional study of data obtained from the Hospital's microbiology laboratory was carried out between January 2020and December 2021. 216 clinical samples were studied, of which 196 (91%) were in adult patients, 172 (80%) were positive for metallo-&#946;-lactamase (MBL) enzymes, Klebsiella pneumoniae was the most frequent species. In patients hospitalized in the Intensive Care Unit these isolates predominated and in urine samples 91 (42%). According to sex, 108 (50%) for both sexes and a median age of 52 years, with a range of 6 days to 92 years. Regarding the number of isolates found, it was higher in 2020 with 121 (56%). Active surveillance together with infection control measures are necessary to limit the spread of carbapenemase-producing microorganisms, in addition, there are necessary data to justify the introduction of antibiotics of choice for these microorganisms into the country.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[carbapenemasas]]></kwd>
<kwd lng="es"><![CDATA[microorganismos]]></kwd>
<kwd lng="es"><![CDATA[vigilancia activa]]></kwd>
<kwd lng="es"><![CDATA[Paraguay]]></kwd>
<kwd lng="en"><![CDATA[carbapenemases]]></kwd>
<kwd lng="en"><![CDATA[microorganisms]]></kwd>
<kwd lng="en"><![CDATA[active surveillance]]></kwd>
<kwd lng="en"><![CDATA[Paraguay]]></kwd>
</kwd-group>
</article-meta>
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