<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1816-8949</journal-id>
<journal-title><![CDATA[Anales de la Facultad de Ciencias Médicas (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[An. Fac. Cienc. Méd. (Asunción)]]></abbrev-journal-title>
<issn>1816-8949</issn>
<publisher>
<publisher-name><![CDATA[EFACIM. Editorial de la Facultad de Ciencias Médicas - Universidad Nacional de Asunción]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1816-89492025000300087</article-id>
<article-id pub-id-type="doi">10.18004/anales/2025.058.03.87</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Infecciones herpéticas atípicas en pacientes inmunodeprimidos.]]></article-title>
<article-title xml:lang="en"><![CDATA[Atypical Herpetic Infections in Immunocompromised Patients]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ibáñez Franco]]></surname>
<given-names><![CDATA[Elvis Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Báez]]></surname>
<given-names><![CDATA[Clara Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montoya Bueno]]></surname>
<given-names><![CDATA[Camila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aldama Caballero]]></surname>
<given-names><![CDATA[Arnaldo Benjamín Feliciano]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Nacional de Itauguá Departamento de Medicina Interna Servicio de Dermatología.]]></institution>
<addr-line><![CDATA[Itauguá ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Nacional de Itauguá. Servicio de anatomía patológica ]]></institution>
<addr-line><![CDATA[Itauguá ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<volume>58</volume>
<numero>3</numero>
<fpage>87</fpage>
<lpage>96</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1816-89492025000300087&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1816-89492025000300087&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1816-89492025000300087&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Las infecciones herpéticas son producidas por virus de la familia Herpesviridae. Los más frecuentes son los que producen el herpes labial, herpes genital y varicela-zóster. En pacientes inmunodeprimidos la presentación clínica puede ser atípica, dificultando el diagnóstico y produciendo complicaciones potencialmente letales. Se presentan 3 casos clínicos de infecciones herpéticas en pacientes inmunodeprimidos. En el primer caso, lesiones ulcerativas extensas en un paciente portador de VIH, con diagnósticos diferenciales entre infecciones fúngicas, micobacterianas y virales, llegando al diagnóstico de infección por herpes tipo 2 mediante biología molecular. Se trató con aciclovir, teniendo una respuesta favorable. En el segundo caso, lesiones papulovesiculares escasas distribuidas en todo el cuerpo en un paciente portador de VIH y antecedente de varicela en la infancia. La sospecha inicial fue una infección fúngica, con retorno de biopsia compatible con infección herpética. Tuvo resolución espontánea de lesiones, debido al retorno tardío del estudio, sin mayores complicaciones. En el tercer caso, lesiones vesicoampollares extensas en tronco y extremidades, con afectación de la mucosa, en paciente con lupus eritematoso sistémico en tratamiento con inmunosupresores. La sospecha inicial fue una dermatosis ampollar autoinmune, retornando la biopsia compatible con infección herpética. Debido a la falla multiorgánica, y el desenlace fatal, el diagnostico fue post mortem y no recibió tratamiento por tal motivo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Herpetic infections are caused by viruses of the Herpesviridae family. The most common are those responsible for oral herpes, genital herpes, and varicella-zoster. In immunocompromised patients, the clinical presentation may be atypical, making diagnosis difficult and leading to potentially lethal complications. Three clinical cases of herpetic infections in immunocompromised patients are presented. The first case involves a patient with HIV presenting with extensive ulcerative lesions. Differential diagnoses included fungal, mycobacterial, and viral infections; a diagnosis of herpes simplex virus type 2 infection was reached via molecular biology. The patient was treated with acyclovir and showed a favorable respons. The second case describes a patient with HIV and a history of childhood varicella, presenting with sparse papulovesicular lesions distributed throughout the body. The initial suspicion was a fungal infection; however, the biopsy returned consistent with a herpes infection. The lesions resolved spontaneously without major complications, as the study results were returned late. The third case involves a patient with systemic lupus erythematosus under immunosuppressive treatment, presenting with extensive vesiculobullous lesions on the trunk and extremities, with mucosal involvement. The initial suspicion was autoimmune bullous dermatosis, but the biopsy was consistent with a herpes infection. Due to multiorgan failure and a fatal outcome, the diagnosis was made post-mortem, and the patient did not receive specific treatment.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[infecciones virales]]></kwd>
<kwd lng="es"><![CDATA[infecciones por herpes virus]]></kwd>
<kwd lng="es"><![CDATA[inmunosupresión]]></kwd>
<kwd lng="es"><![CDATA[reporte de caso.]]></kwd>
<kwd lng="en"><![CDATA[viral infections]]></kwd>
<kwd lng="en"><![CDATA[herpes virus infections]]></kwd>
<kwd lng="en"><![CDATA[immunosuppression]]></kwd>
<kwd lng="en"><![CDATA[case report.]]></kwd>
</kwd-group>
</article-meta>
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