<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1816-8949</journal-id>
<journal-title><![CDATA[Anales de la Facultad de Ciencias Médicas (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[An. Fac. Cienc. Méd. (Asunción)]]></abbrev-journal-title>
<issn>1816-8949</issn>
<publisher>
<publisher-name><![CDATA[EFACIM. Editorial de la Facultad de Ciencias Médicas - Universidad Nacional de Asunción]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1816-89492025000300062</article-id>
<article-id pub-id-type="doi">10.18004/anales/2025.058.03.62</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Tratamiento No Quirúrgico de Varices CEAP 2 Utilizando Flebogrif® MOCA: Serie de 5 Casos en el Centro Paraguayo de Varices]]></article-title>
<article-title xml:lang="en"><![CDATA[Non-Surgical Treatment of CEAP 2 Varicose Veins Using Flebogrif® MOCA: Series of 5 Cases at the Paraguayan Varicose Veins Center]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Canata]]></surname>
<given-names><![CDATA[Victor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez]]></surname>
<given-names><![CDATA[María Victoria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Núñez]]></surname>
<given-names><![CDATA[Gladys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leticia]]></surname>
<given-names><![CDATA[Quiroga]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Cátedra de Clínica Quirúrgica]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Paraguayo de Várices (CEPAVA).  ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<volume>58</volume>
<numero>3</numero>
<fpage>62</fpage>
<lpage>68</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1816-89492025000300062&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1816-89492025000300062&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1816-89492025000300062&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Objetivo:  Evaluar la eficacia y seguridad del dispositivo Flebogrif® para ablación mecanoquímica (MOCA) en el tratamiento de varices CEAP 2.  Métodos:  Serie de casos prospectiva de cinco pacientes (cuatro mujeres, un hombre) con varices CEAP 2 tratados con Flebogrif® entre enero y julio de 2023. Se realizó evaluación pre-tratamiento con ecografía dúplex y seguimiento a 1, 3, 6 y 18 meses post-tratamiento.  Resultados:  Todos los pacientes mantuvieron oclusión venosa completa a los 18 meses sin evidencia de recanalización. Se observó reducción significativa del dolor y mejora en la calidad de vida en todos los casos. No se registraron complicaciones mayores.  Conclusión:  MOCA con Flebogrif® demostró ser una alternativa segura, eficaz y económica para el tratamiento de insuficiencia safena con resultados prometedores a corto plazo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Objective:  To evaluate the efficacy and safety of the Flebogrif® device for mechanochemical ablation (MOCA) in treating CEAP 2 varicose veins.  Methods:  Prospective case series of five patients (four women, one man) with CEAP 2 varicose veins treated with Flebogrif® between January and July 2023. Pre-treatment evaluation with duplex ultrasound and follow-up at 1-, 3-, 6-, and 18-months post-treatment was performed.  Results:  All patients maintained complete vein occlusion at 18 months without evidence of recanalization. Significant pain reduction and quality of life improvement were observed in all cases. No major complications were recorded.  Conclusion:  MOCA with Flebogrif® proved to be a safe, effective, and economical alternative for treating saphenous insufficiency with promising short-term results.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Varices]]></kwd>
<kwd lng="es"><![CDATA[Flebogrif]]></kwd>
<kwd lng="es"><![CDATA[ablación mecanoquímica]]></kwd>
<kwd lng="es"><![CDATA[insuficiencia venosa crónica]]></kwd>
<kwd lng="es"><![CDATA[ecografía dúplex]]></kwd>
<kwd lng="es"><![CDATA[clasificación CEAP.]]></kwd>
<kwd lng="en"><![CDATA[Varicose veins]]></kwd>
<kwd lng="en"><![CDATA[Flebogrif]]></kwd>
<kwd lng="en"><![CDATA[mechanochemical ablation]]></kwd>
<kwd lng="en"><![CDATA[chronic venous insufficiency]]></kwd>
<kwd lng="en"><![CDATA[duplex ultrasound]]></kwd>
<kwd lng="en"><![CDATA[CEAP classification]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rabe]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Guex]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Puskas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Scuderi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Fernandez Quesada]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[VCP Coordinators. Epidemiology of chronic venous disease in geographically diverse populations: results from the Vein Consult Program.]]></article-title>
<source><![CDATA[Int Angiol]]></source>
<year>2012</year>
<volume>31</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>105-15</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lurie]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Passman]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Meisner]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Dalsing]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Masuda]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Welch]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The 2020 update of the CEAP classification system and reporting standards]]></article-title>
<source><![CDATA[J Vasc Surg Venous Lymphat Disord.]]></source>
<year>2020</year>
<volume>8</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>342-52</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Canata]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Moraes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ablación mecánico química (MOCA) de la vena safena con catéter Clarivein®. Primera experiencia en Paraguay en el centro paraguayo de varices (CEPAVA).]]></article-title>
<source><![CDATA[Reporte de tres primeros casos. Cirugía Paraguaya.]]></source>
<year>2022</year>
<volume>46</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>22-4</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ammollo]]></surname>
<given-names><![CDATA[RP]]></given-names>
</name>
<name>
<surname><![CDATA[Petrone]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Giribono]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Ferrante]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Del Guercio]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Bracale]]></surname>
<given-names><![CDATA[UM.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Early Results of Mechanochemical Ablation with Flebogrif® in great Saphenous Vein Insufficiency: does Polidocanol Concentration Affect Outcome?]]></article-title>
<source><![CDATA[Transl Med UniSa]]></source>
<year>2020</year>
<volume>21</volume>
<page-range>47-51</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reina Gutiérrez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Fernández Solares]]></surname>
<given-names><![CDATA[JI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ablación mecánico-química de la vena safena con el catéter ClariVein® (MOCA): aspectos técnicos y revisión de la literatura]]></article-title>
<source><![CDATA[Angiología]]></source>
<year>2018</year>
<volume>70</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>25-32</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bootun]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Lane]]></surname>
<given-names><![CDATA[TR]]></given-names>
</name>
<name>
<surname><![CDATA[Davies]]></surname>
<given-names><![CDATA[AH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The advent of non-thermal, non-tumescent techniques for treatment of varicose veins]]></article-title>
<source><![CDATA[Phlebology]]></source>
<year>2016</year>
<volume>31</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>5-14.</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Eklöf]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Rutherford]]></surname>
<given-names><![CDATA[RB]]></given-names>
</name>
<name>
<surname><![CDATA[Bergan]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Carpentier]]></surname>
<given-names><![CDATA[PH]]></given-names>
</name>
<name>
<surname><![CDATA[Gloviczki]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Kistner]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Revision of the CEAP classification for chronic venous disorders: consensus statement]]></article-title>
<source><![CDATA[J Vasc Surg.]]></source>
<year>2004</year>
<volume>40</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1248-52</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[I&#322;&#380;ecki]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Terlecki]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Przywara]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Urbanek]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Pedrycz-Wieczorska]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Dave]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Zubilewicz]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A new device for minimally invasive mechano-chemical method of saphenous vein ablation. Report of 12 months of follow up.]]></article-title>
<source><![CDATA[Acta Angiol.]]></source>
<year>2018</year>
<volume>24</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>70-3</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[I&#322;&#380;ecki]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Terlecki]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Przywara]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Urbanek]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Pedrycz-Wieczorska]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Dave]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The novel minimally invasive mechano-chemical technique of the saphenous vein ablation. Our center experience: results of 24 months follow-up.]]></article-title>
<source><![CDATA[Acta Angiol.]]></source>
<year>2019</year>
<volume>25</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>127-32</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alozai]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Huizing]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Schreve]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mooij]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[van Vlijmen]]></surname>
<given-names><![CDATA[CJ]]></given-names>
</name>
<name>
<surname><![CDATA[Wisselink]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A systematic review and meta-analysis of mechanochemical endovenous ablation using Flebogrif for varicose veins.]]></article-title>
<source><![CDATA[J Vasc Surg Venous Lymphat Disord.]]></source>
<year>2022</year>
<volume>10</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>248-57</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vähäaho]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Halmesmäki]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Mahmoud]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Albäck]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Noronen]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Venermo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Three-year results of a randomized controlled trial comparing mechanochemical and thermal ablation in the treatment of insufficient great saphenous veins.]]></article-title>
<source><![CDATA[J Vasc Surg Venous Lymphat Disord.]]></source>
<year>2021</year>
<volume>9</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>652-9</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boersma]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[van Eekeren]]></surname>
<given-names><![CDATA[RR]]></given-names>
</name>
<name>
<surname><![CDATA[Werson]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[van der Waal]]></surname>
<given-names><![CDATA[RI]]></given-names>
</name>
<name>
<surname><![CDATA[Reijnen]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[de Vries]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mechanochemical endovenous ablation versus radiofrequency ablation in the treatment of primary great saphenous vein incompetence: 1-year results of a European multicenter randomized controlled trial (MARADONA)]]></article-title>
<source><![CDATA[Trials]]></source>
<year>2014</year>
<volume>15</volume>
<page-range>121</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Razaque]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Shazlee]]></surname>
<given-names><![CDATA[MK]]></given-names>
</name>
<name>
<surname><![CDATA[Qamar]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Hyder]]></surname>
<given-names><![CDATA[SMS]]></given-names>
</name>
<name>
<surname><![CDATA[Adel]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Early Results of Mechanochemical Ablation by Flebogrif and Radiofrequency Ablation in Treating Primary Varicose Veins of Lower Limb]]></article-title>
<source><![CDATA[Cureus]]></source>
<year>2023</year>
<volume>15</volume>
<numero>9</numero>
<issue>9</issue>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gibson]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Ferris]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cyanoacrylate closure of incompetent great, small and accessory saphenous veins without the use of post-procedure compression: Initial outcomes of a post-market evaluation of the VenaSeal System (the WAVES Study).]]></article-title>
<source><![CDATA[Vascular]]></source>
<year>2017</year>
<volume>25</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>149-56</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
