<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1816-8949</journal-id>
<journal-title><![CDATA[Anales de la Facultad de Ciencias Médicas (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[An. Fac. Cienc. Méd. (Asunción)]]></abbrev-journal-title>
<issn>1816-8949</issn>
<publisher>
<publisher-name><![CDATA[EFACIM. Editorial de la Facultad de Ciencias Médicas - Universidad Nacional de Asunción]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1816-89492025000300043</article-id>
<article-id pub-id-type="doi">10.18004/anales/2025.058.03.43</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Ensayo Clínico Aleatorizado sobre el Efecto de administración de Ilex paraguariensis como infusión (mate o tereré) en la absorción intestinal de levotiroxina sódica.]]></article-title>
<article-title xml:lang="en"><![CDATA[Randomized Clinical Trial on the Effect of administering Ilex paraguariensis as an infusion (mate or tereré) on the intestinal absorption of levothyroxine sodium.]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bueno Colman]]></surname>
<given-names><![CDATA[Elvio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz Díaz Benítez]]></surname>
<given-names><![CDATA[Daisy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Benítez García]]></surname>
<given-names><![CDATA[Aldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Palacios]]></surname>
<given-names><![CDATA[Mafalda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez]]></surname>
<given-names><![CDATA[Jorge]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Argüello Ayala]]></surname>
<given-names><![CDATA[Rocío]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernandez Miranda]]></surname>
<given-names><![CDATA[Liliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz Diaz Benítez]]></surname>
<given-names><![CDATA[Dalila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Gayoso]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pintos Belotto]]></surname>
<given-names><![CDATA[Misael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz Diaz Politeo]]></surname>
<given-names><![CDATA[Oscar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuevas de Villalba]]></surname>
<given-names><![CDATA[María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Segovia Cuquejo]]></surname>
<given-names><![CDATA[Clotilde]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas, Hospital de Clínicas, Departamento de Endocrinología y Metabolismo.]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Asunción, Facultad de Ciencias Médicas Hospital de Clínicas, Departamento de Neonatología.]]></institution>
<addr-line><![CDATA[San Lorenzo, ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas, Hospital de Clínicas, Departamento de Cadiología]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas, Hospital de Clínicas, Departamento de Imagenología]]></institution>
<addr-line><![CDATA[San Lorenzo, ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Hospital de Clínicas]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2025</year>
</pub-date>
<volume>58</volume>
<numero>3</numero>
<fpage>43</fpage>
<lpage>51</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1816-89492025000300043&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1816-89492025000300043&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1816-89492025000300043&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La absorción de levotiroxina (LT4) se ve afectada por medicamentos y alimentos. El consumo de Ilex paraguariensis (IP) como infusión con agua caliente (mate) o con agua fría (tereré) es popular en el Cono Sur.  Objetivo:  Comparar la absorción de LT4 con IP frente a agua simple.  Materiales y Métodos:  Se realizó un estudio farmacocinético en voluntarios eutiroideos sanos. Se administraron 1000 µg de LT4 con mate, agua y tereré respectivamente. Se realizaron dosificaciones seriadas de tiroxina total en sangre (TT4), se compararon las concentraciones plasmáticas máximas medias de TT4 (Cmax), tiempo medio para alcanzar la Cmax (Tmax), variación de la hormona estimulante de la tiroides (TSH) en 24 horas (&#916; TSH) y porcentaje estimado de absorción de LT4 (%Abs). El protocolo fue aprobado por Comité de Ética.  Resultados:  Veinte voluntarios completaron el estudio. Las diferencias en Cmax, Tmax y %Abs de LT4 y agua frente a LT4 y mate fueron estadísticamente significativas (Cmax: 17,38µg/dl vs 14,95µg/dl, p=0,02; Tmax: 3hs vs 4,2hs, p=0,03; y %Abs 104,83% vs 76,42%, p=0,05). No hubo diferencias estadísticamente significativas al comparar LT4 y agua frente a LT4 y tereré (Cmax: 16,36µg/dl, p=0,29; Tmax: 4hs, p=0,09; y %Abs 90,76%, p=0,15). En cuanto a &#916;TSH, LT4 y agua resultaron en 1,1uUI/ml versus LT4 y mate 1,09uUI/ml (p= 0,96) o LT4 y tereré 1,35uUI/ml (p= 0,31), sin diferencias estadísticamente significativas.  Conclusiones:  La absorción de LT4 fue menor cuando la administración fue con mate y no con tereré, en comparación con agua.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The absorption of levothyroxine (LT4) is affected by medications and food. Consumption of Ilex paraguariensis (IP) as an infusion with hot water (mate) or cold water (tereré) is popular in the Southern Cone of Latin America.  Objective:  To compare LT4 absorption with IP versus plain water.  Materials and Methods:  A pharmacokinetic study was conducted in healthy euthyroid volunteers. A dose of 1000 µg LT4 was administered with mate, plain water, and tereré, respectively. Serial measurements of total blood thyroxine (TT4) were performed, and mean peak plasma concentrations of TT4 (Cmax), mean time to reach Cmax (Tmax), 24-hour change in thyroid-stimulating hormone (TSH) (&#916;TSH), and estimated percentage of LT4 absorption (%Abs) were compared. The protocol was approved by an Ethics Committee.  Results:  Twenty volunteers completed the study. Differences in Cmax, Tmax, and %Abs between LT4 with plain water and LT4 with mate were statistically significant (Cmax: 17.38 µg/dL vs 14.95 µg/dL, p=0.02; Tmax: 3h vs 4.2h, p=0.03; %Abs: 104.83% vs 76.42%, p=0.05). No statistically significant differences were found when comparing LT4 with plain water versus LT4 with tereré (Cmax: 16.36 µg/dL, p=0.29; Tmax: 4 h, p=0.09; %Abs: 90.76%, p=0.15). Regarding &#916;TSH, LT4 with plain water resulted in 1.1 µIU/mL versus LT4 with mate 1.09 µIU/mL (p=0.96) or LT4 with tereré 1.35 µIU/mL (p=0.31), without statistically significant differences.  Conclusions:  LT4 absorption was lower when administered with mate, but not with tereré, compared with plain water.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[levotiroxina]]></kwd>
<kwd lng="es"><![CDATA[Ilex paraguariensis]]></kwd>
<kwd lng="es"><![CDATA[yerba mate]]></kwd>
<kwd lng="es"><![CDATA[terere]]></kwd>
<kwd lng="es"><![CDATA[absorción.]]></kwd>
<kwd lng="en"><![CDATA[levothyroxine]]></kwd>
<kwd lng="en"><![CDATA[Ilex paraguariensis]]></kwd>
<kwd lng="en"><![CDATA[yerba mate]]></kwd>
<kwd lng="en"><![CDATA[tereré]]></kwd>
<kwd lng="en"><![CDATA[absorption.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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