<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1816-8949</journal-id>
<journal-title><![CDATA[Anales de la Facultad de Ciencias Médicas (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[An. Fac. Cienc. Méd. (Asunción)]]></abbrev-journal-title>
<issn>1816-8949</issn>
<publisher>
<publisher-name><![CDATA[EFACIM. Editorial de la Facultad de Ciencias Médicas - Universidad Nacional de Asunción]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1816-89492025000100095</article-id>
<article-id pub-id-type="doi">10.18004/anales/2025.058.01.95</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[LUPUS NEONATAL. Reporte de 3 casos]]></article-title>
<article-title xml:lang="en"><![CDATA[NEONATAL LUPUS. Report of 3 cases]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Buongermini Götz]]></surname>
<given-names><![CDATA[Ana Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Samaniego Contreras]]></surname>
<given-names><![CDATA[Pierina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montiel Centurión]]></surname>
<given-names><![CDATA[Judith Nelsi]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Di Martino Ortiz]]></surname>
<given-names><![CDATA[Beatriz María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aldama Caballero]]></surname>
<given-names><![CDATA[Arnaldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas. Hospital de Clínicas. Cátedra y Servicio de Dermatología]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<volume>58</volume>
<numero>1</numero>
<fpage>95</fpage>
<lpage>103</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1816-89492025000100095&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1816-89492025000100095&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1816-89492025000100095&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El lupus eritematoso neonatal (LEN) es una enfermedad autoinmune poco frecuente en el recién nacido (RN), dada por el paso transplacentario de autoanticuerpos maternos. Se asocia a manifestaciones cutáneas características y extracutáneas. Se presentan 3 casos con manifestaciones cutáneas como síntoma principal, uno hijo de madre con diagnóstico de Síndrome de Sjögren (SS) y otros dos hijos de madre sin diagnóstico conocido de enfermedad autoinmune al momento del parto, con diagnóstico de Lupus Eritematoso Sistémico (LES) durante el puerperio y una de ellas con desenlace fatal. Todos los lactantes con evolución favorable. Se destaca la importancia del diagnóstico precoz, para el correcto manejo del niño y/o el diagnóstico en ocasiones de una enfermedad autoinmune materna.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Neonatal lupus erythematosus (NLE) is a rare autoimmune disease in newborns, caused by the transplacental transfer of maternal autoantibodies. It is associated with characteristic cutaneous and extracutaneous manifestations. We present three cases with cutaneous manifestations as the main symptom: one born to a mother previously diagnosed with Sjögren&#8217;s syndrome (SS), and two born to mothers without a known autoimmune disease at the time of delivery, later diagnosed with systemic lupus erythematosus (SLE) during the postpartum period-one of whom had a fatal outcome. All infants had a favorable clinical course. This report highlights the importance of early diagnosis for proper neonatal management and, in some cases, for the detection of an underlying maternal autoimmune disease.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Lupus neonatal]]></kwd>
<kwd lng="es"><![CDATA[enfermedad autoinmune materna]]></kwd>
<kwd lng="en"><![CDATA[Neonatal lupus]]></kwd>
<kwd lng="en"><![CDATA[maternal autoimmune disease]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aguilera Peiró]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Vicente Villa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Antonia González-Enseñat]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lupus eritematoso neonatal.]]></article-title>
<source><![CDATA[Semin Fund Esp Reumatol.]]></source>
<year>2011</year>
<volume>12</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>15-20</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Díaz-Frías]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Badri]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neonatal Lupus Erythematosus]]></article-title>
<source><![CDATA[StatPearls Publishing]]></source>
<year>2022</year>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Derdulska]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Rudnicka]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Szykut-Badaczewska]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Mehrholz]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Nowicki]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Bara&#324;ska-Rybak]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neonatal lupus erythematosus - practical guidelines]]></article-title>
<source><![CDATA[J Perinat Med]]></source>
<year>2021</year>
<volume>49</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>529-38</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Manthorpe]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Svensson]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Wirestrand]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Late neonatal lupus erythematosus onset in a child born of a mother with primary Sjögren&#8217;s syndrome]]></article-title>
<source><![CDATA[Ann Rheum Dis]]></source>
<year>2004</year>
<volume>63</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1496-7</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stea]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<name>
<surname><![CDATA[Routsias]]></surname>
<given-names><![CDATA[JG]]></given-names>
</name>
<name>
<surname><![CDATA[Clancy]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Buyon]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
<name>
<surname><![CDATA[Moutsopoulos]]></surname>
<given-names><![CDATA[HM]]></given-names>
</name>
<name>
<surname><![CDATA[Tzioufas]]></surname>
<given-names><![CDATA[AG]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anti-La/SSB antiidiotypic antibodies in maternal serum: a marker of low risk for neonatal lupus in an offspring]]></article-title>
<source><![CDATA[Arthritis Rheum]]></source>
<year>2006</year>
<volume>54</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>2228-34</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[León Muiños]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Monteagudo Sánchez]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Luaces González]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[García Santiago]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lupus eritematoso neonatal]]></article-title>
<source><![CDATA[An Pediatría]]></source>
<year>2008</year>
<volume>69</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>185-6</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[McCune]]></surname>
<given-names><![CDATA[AB]]></given-names>
</name>
<name>
<surname><![CDATA[Weston]]></surname>
<given-names><![CDATA[WL]]></given-names>
</name>
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Maternal and fetal outcome in neonatal lupus erythematosus.]]></article-title>
<source><![CDATA[Ann Intern Med]]></source>
<year>1987</year>
<volume>106</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>518-23</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Montané]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Hojman]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Hasbún]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Montané]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Hojman]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Hasbún]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lupus eritematoso neonatal, caso clínico]]></article-title>
<source><![CDATA[Andes Pediatr.]]></source>
<year>2023</year>
<volume>94</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>240-5</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kumar]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Bhatia]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Detection of antinuclear antibodies in SLE]]></article-title>
<source><![CDATA[Methods Mol Biol]]></source>
<year>2014</year>
<volume>1134</volume>
<page-range>37-45</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[LA.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neonatal lupus: clinical features, therapy, and pathogenesis]]></article-title>
<source><![CDATA[Curr Rheumatol Rep]]></source>
<year>2001</year>
<volume>3</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>391-5</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Clowse]]></surname>
<given-names><![CDATA[MEB]]></given-names>
</name>
<name>
<surname><![CDATA[Eudy]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
<name>
<surname><![CDATA[Kiernan]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Williams]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
<name>
<surname><![CDATA[Bermas]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Chakravarty]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The prevention, screening and treatment of congenital heart block from neonatal lupus: a survey of provider practices]]></article-title>
<source><![CDATA[Rheumatol (Oxford)]]></source>
<year>2018</year>
<volume>57</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>v9-17</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lee]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neonatal lupus erythematosus: clinical findings and pathogenesis.]]></article-title>
<source><![CDATA[J Investig Dermatol Symp Proc]]></source>
<year>2004</year>
<volume>9</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>52-6</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arias]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Irala]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Zapata]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Fonseca]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Morel]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lupus neonatal. Reporte de un caso]]></article-title>
<source><![CDATA[Pediatr. (Asunción)]]></source>
<year>2019</year>
<volume>46</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>115-7</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
