<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1816-8949</journal-id>
<journal-title><![CDATA[Anales de la Facultad de Ciencias Médicas (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[An. Fac. Cienc. Méd. (Asunción)]]></abbrev-journal-title>
<issn>1816-8949</issn>
<publisher>
<publisher-name><![CDATA[EFACIM. Editorial de la Facultad de Ciencias Médicas - Universidad Nacional de Asunción]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1816-89492025000100065</article-id>
<article-id pub-id-type="doi">10.18004/anales/2025.058.01.65</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efecto de la cola de caballo (Equisetum giganteum) en la diuresis, eliminación de sodio y la presión arterial en ratas wistar]]></article-title>
<article-title xml:lang="en"><![CDATA[Effect of horsetail (Equisetum giganteum) on diuresis, sodium elimination and blood pressure in wistar rats]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barreto]]></surname>
<given-names><![CDATA[Susana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Acosta]]></surname>
<given-names><![CDATA[Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[Héctor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Abente]]></surname>
<given-names><![CDATA[Silvia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Malvetti]]></surname>
<given-names><![CDATA[Victoria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Velázquez]]></surname>
<given-names><![CDATA[Sebastián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Franco]]></surname>
<given-names><![CDATA[Natalia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez]]></surname>
<given-names><![CDATA[Roccio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Walder]]></surname>
<given-names><![CDATA[Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Campuzano]]></surname>
<given-names><![CDATA[Araceli]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Cátedra de Fisiopatología]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Laboratorio Meyer Lab  ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2025</year>
</pub-date>
<volume>58</volume>
<numero>1</numero>
<fpage>65</fpage>
<lpage>72</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1816-89492025000100065&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1816-89492025000100065&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1816-89492025000100065&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La cola de caballo (Equisetum) es una planta medicinal utilizada tradicionalmente como diurético, sobre todo es conocida la especie Equisetum arvense. En nuestro país existe la especie Equisetum giganteum, su efecto a largo plazo sobre la diuresis, la eliminación de sodio y la presión arterial en ratas, no ha sido investigado exhaustivamente.  Objetivo:  Evaluar el efecto de la administración prolongada de Equisetum giganteum en la diuresis, la eliminación de sodio y la presión arterial en ratas Wistar macho.  Material y Métodos:  Se utilizaron 20 ratas Wistar macho divididas en dos grupos: control (agua) y experimental (infusión de Equisetum giganteum). Se midieron la diuresis, la natriuria y la presión arterial sistólica, diastólica al inicio y a las 16 semanas. Se realizaron análisis estadísticos utilizando la prueba t de Student.  Resultados:  En el grupo cola de caballo se observó un aumento significativo en la eliminación de sodio en orina de 24 h (p&lt;0,01), disminución de la diuresis al final y disminución de la PAS (p=0,05) en relación al grupo que recibió agua, en la PAD no hubo diferencia.  Conclusión:  La administración prolongada de Equisetum giganteum tuvo un efecto diurético con natriuresis, así como una disminución de la diuresis y de la presión arterial sistólica, que manifiesta hipovolemia, en ratas Wistar.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Horsetail (Equisetum) is a medicinal plant traditionally used as a diuretic, with Equisetum arvense being the most well-known species. In our country, the species Equisetum giganteum exists, but its long-term effect on diuresis, sodium elimination, and blood pressure in rats has not been extensively investigated.  Objective:  To evaluate the effect of prolonged administration of Equisetum giganteum on diuresis, sodium elimination, and blood pressure in male Wistar rats.  Materials and Methods:  Twenty male Wistar rats were divided in two groups: control (water) and experimental (Equisetum giganteum infusion). Diuresis, natriuresis, and systolic and diastolic blood pressure were measured at the beginning and after 16 weeks. Statistical analyses were performed using Student's t-test.  Results:  In the horsetail group, a significant increase in 24-hour urinary sodium elimination (p&lt;0.01), a decrease in diuresis at the end, and a decrease in systolic blood pressure (p=0.05) were observed compared to the water group. There was no difference in diastolic blood pressure.  Conclusion:  Prolonged administration of Equisetum giganteum had a diuretic effect with natriuresis, as well as a decrease in diuresis and systolic blood pressure, which indicates hypovolemia, in Wistar rats.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cola de caballo]]></kwd>
<kwd lng="es"><![CDATA[Equisetum giganteum]]></kwd>
<kwd lng="es"><![CDATA[diuresis]]></kwd>
<kwd lng="es"><![CDATA[natriuresis]]></kwd>
<kwd lng="es"><![CDATA[diurético]]></kwd>
<kwd lng="es"><![CDATA[medición presión arterial en ratas.]]></kwd>
<kwd lng="en"><![CDATA[Horsetail]]></kwd>
<kwd lng="en"><![CDATA[Equisetum giganteum]]></kwd>
<kwd lng="en"><![CDATA[diuresis]]></kwd>
<kwd lng="en"><![CDATA[sodium]]></kwd>
<kwd lng="en"><![CDATA[diuretic]]></kwd>
<kwd lng="en"><![CDATA[blood pressure]]></kwd>
<kwd lng="en"><![CDATA[experimental]]></kwd>
<kwd lng="en"><![CDATA[rats.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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