<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1683-9803</journal-id>
<journal-title><![CDATA[Pediatría (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[Pediatr. (Asunción)]]></abbrev-journal-title>
<issn>1683-9803</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Pediatría]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1683-98032026000100100</article-id>
<article-id pub-id-type="doi">10.31698/ped.53012026013</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Descompensación adrenal y renal en adolescente con hiperplasia suprarrenal congénita no tratada. Estudio de Caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Adrenal and renal decompensation in an adolescent with untreated congenital adrenal hyperplasia. A case study]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ceballos-Dosantos]]></surname>
<given-names><![CDATA[Ana Maria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pulido-Peralta]]></surname>
<given-names><![CDATA[Paula Fernanda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreno-Cavanzo]]></surname>
<given-names><![CDATA[Julián David]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Agudelo]]></surname>
<given-names><![CDATA[Lorena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas-Urrea]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Regional de la Orinoquía Departamento de Investigación ]]></institution>
<addr-line><![CDATA[Yopal ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2026</year>
</pub-date>
<volume>53</volume>
<numero>1</numero>
<fpage>100</fpage>
<lpage>104</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1683-98032026000100100&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1683-98032026000100100&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1683-98032026000100100&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La hiperplasia suprarrenal congénita comprende una serie de trastornos hereditarios que afectan la síntesis de cortisol, lo que conduce a una excesiva producción de andrógenos suprarrenales prenatales y la virilización de los genitales externos femeninos. En función del déficit enzimático, se conocen siete formas clínicas y la más frecuente es el déficit de 21-hidroxilasa, causada por mutaciones en el gen CYP21A2. La manifestación clínica predominante es la insuficiencia suprarrenal primaria. El tratamiento consiste en la administración de glucocorticoides y mineralocorticoides para evitar la crisis adrenal y la morbimortalidad del shock hipovolémico. Además, consecuentemente, reducir los niveles de andrógenos y el grado de virilización. Se reporta el caso de una niña de 15 años que, por falta de acceso al tratamiento por problemas socioeconómicos, la llevó a complicaciones de crisis de pérdida salina. Se resalta la importancia del diagnóstico y manejo temprano para prevenir complicaciones graves y mortalidad asociada a crisis adrenales.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Congenital adrenal hyperplasia comprises a series of inherited disorders that affect cortisol synthesis, leading to excessive prenatal adrenal androgen production and virilization of the external female genitalia. Based on the enzyme deficiency, seven clinical forms are known, the most frequent being 21-hydroxylase deficiency, caused by mutations in the CYP21A2 gene. The predominant clinical manifestation is primary adrenal insufficiency. Treatment consists of administering glucocorticoids and mineralocorticoids to prevent adrenal crisis and the morbidity and mortality associated with hypovolemic shock. This also aims to reduce androgen levels and the degree of virilization. We report the case of a 15-year-old girl who, due to lack of access to treatment caused by socioeconomic problems, experienced complications from salt-wasting crisis. The importance of early diagnosis and management is highlighted to prevent serious complications and mortality associated with adrenal crises.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Hiperplasia suprarrenal congénita]]></kwd>
<kwd lng="es"><![CDATA[trastornos del desarrollo sexual]]></kwd>
<kwd lng="es"><![CDATA[glucocorticoides]]></kwd>
<kwd lng="es"><![CDATA[mineralocorticoides]]></kwd>
<kwd lng="es"><![CDATA[virilismo]]></kwd>
<kwd lng="en"><![CDATA[Congenital adrenal hyperplasia]]></kwd>
<kwd lng="en"><![CDATA[disorders of sexual development]]></kwd>
<kwd lng="en"><![CDATA[glucocorticoids]]></kwd>
<kwd lng="en"><![CDATA[mineralocorticoids]]></kwd>
<kwd lng="en"><![CDATA[virilism]]></kwd>
</kwd-group>
</article-meta>
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