<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1683-9803</journal-id>
<journal-title><![CDATA[Pediatría (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[Pediatr. (Asunción)]]></abbrev-journal-title>
<issn>1683-9803</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Pediatría]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1683-98032024000300181</article-id>
<article-id pub-id-type="doi">10.31698/ped.51032024005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Perfil microbiológico de especies de cándida aisladas de hemocultivos de pacientes pediátricos. Años 2019 a 2023]]></article-title>
<article-title xml:lang="en"><![CDATA[Microbiological profile of candida species isolated from blood cultures of pediatric patients, 2019 to 2023]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Samudio Domínguez]]></surname>
<given-names><![CDATA[Gloria Celeste]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortega Gaona]]></surname>
<given-names><![CDATA[Natalia Berenice]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alfonso]]></surname>
<given-names><![CDATA[Liz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gustavo]]></surname>
<given-names><![CDATA[Aguilar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quintero]]></surname>
<given-names><![CDATA[Lorena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad María Auxiliadora  ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Previsión Social Hospital Central ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2024</year>
</pub-date>
<volume>51</volume>
<numero>3</numero>
<fpage>181</fpage>
<lpage>186</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1683-98032024000300181&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1683-98032024000300181&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1683-98032024000300181&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La candidiasis invasiva es de adquisición nosocomial. Se presenta principalmente en pacientes con inmunosupresión o antecedentes de riesgo tales como cirugías, nutrición parenteral o esquemas amplios de antibióticos. La emergencia de resistencia a los antifúngicos de uso común ha generado gran preocupación a nivel global.  Objetivo: Describir el perfil microbiológico de las especies de Candida aisladas de hemocultivos de población pediátrica.  Material y métodos : estudio restrospectivo, observacional, descriptivo de prevalencias. Se tomó hemocultivos de pacientes pediátricos en el periodo comprendido de los años 2019 al 2023 en un hospital de tercer nivel. Para la identificación y medición de sensibilidad se utilizó MS- MALDITOFF( y placas de microdilución comercial.  Resultados:  se incluyeron 48 cepas de Cándida, 30 % de los pacientes con cultivos positivos a la levadura correspondió a lactantes menores y recién nacidos. El aislamiento fue más frecuente en pacientes internados en salas de terapia intensiva y neonatología. Las especies más frecuentes fueron C parapsilosis (37%), C albicans (30%), C tropicalis (21%), seguidas por otras especies de C no albicans en menor proporción. La sensibilidad para el fluconazol fue de 94% para C parapsilosis. El resto de las cepas no presentó resistencia a voriconazol ni fluconazol.  Conclusión:  Las especies de Cándida más frecuentemente aisladas en hemocultivos fueron la C. parapsilosis, C albicans y C tropicalis, afectando principalmente a recién nacidos y lactantes menores. La sensibilidad a voriconazol se mantiene en 100%, pero han aparecido cepas dosis dependientes y resistentes al fluconazol. Se precisa definir punto de corte para anfotericina B.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Invasive candidiasis is nosocomial. It occurs mainly in patients with immunosuppression or a history of risk factors such as surgery, parenteral nutrition or extensive antibiotic regimens. The emergence of resistance to commonly used antifungals has generated great concern globally.  Objective: To describe the microbiological profile of Candida species isolated from blood cultures of the pediatric population.  Material and methods: This was a retrospective, observational and descriptive prevalence study. Blood cultures were taken from pediatric patients during the 2019 to 2023 time period at a referral hospital. For identification and sensitivity measurement, MS-MALDITOFF® and commercial microdilution plates were used.  Results: 48 Candida strains were included, 30% of patients with positive yeast cultures were infants and newborns. Isolation was more frequent in patients admitted to intensive care and neonatal wards. The most frequent species were C. parapsilosis (37%), C. albicans (30%), C. tropicalis (21%), followed by other non-albicans Candida species to a lesser extent. Sensitivity to fluconazole was 94% for C. parapsilosis. The rest of the strains did not present resistance to voriconazole or fluconazole.  Conclusion:  The Candida species most frequently isolated in blood cultures were C. parapsilosis, C. albicans and C. tropicalis, affecting mainly newborns and infants. Sensitivity to voriconazole remains at 100%, but dose-dependent strains resistant to fluconazole have appeared. A cut-off point for amphotericin B needs to be defined.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cándida]]></kwd>
<kwd lng="es"><![CDATA[hemocultivo]]></kwd>
<kwd lng="es"><![CDATA[sensibilidad]]></kwd>
<kwd lng="es"><![CDATA[resistencia]]></kwd>
<kwd lng="en"><![CDATA[Candida]]></kwd>
<kwd lng="en"><![CDATA[blood culture]]></kwd>
<kwd lng="en"><![CDATA[sensitivity]]></kwd>
<kwd lng="en"><![CDATA[resistance]]></kwd>
</kwd-group>
</article-meta>
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