<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1683-9803</journal-id>
<journal-title><![CDATA[Pediatría (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[Pediatr. (Asunción)]]></abbrev-journal-title>
<issn>1683-9803</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Pediatría]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1683-98032024000200127</article-id>
<article-id pub-id-type="doi">10.31698/ped.51022024008</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Cetoacidosis diabética en niños y adolescentes. Actualización en diagnóstico y tratamiento]]></article-title>
<article-title xml:lang="en"><![CDATA[Diabetic Ketoacidosis in Children and Adolescents. Update in Diagnosis and Treatment]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Blanco Espinola]]></surname>
<given-names><![CDATA[Claudia Fabiola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A5"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rolón]]></surname>
<given-names><![CDATA[María Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Anzoátegui Espínola]]></surname>
<given-names><![CDATA[Roque Esteban]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A5"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Neves de Souza Espínola]]></surname>
<given-names><![CDATA[Claudia Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Cátedra y Servicio de Pediatría]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Previsión Social Hospital Central Departamento de Pediatría]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Ministerio de Salud Publica y Bienestar Social  Programa Nacional de Diabetes]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Instituto de Previsión Social Hospital Regional de Pedro Juan Caballero ]]></institution>
<addr-line><![CDATA[Pedro Juan Caballero ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Sociedad Paraguaya de Pediatría Comité de Endocrinología ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2024</year>
</pub-date>
<volume>51</volume>
<numero>2</numero>
<fpage>127</fpage>
<lpage>139</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1683-98032024000200127&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1683-98032024000200127&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1683-98032024000200127&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La cetoacidosis diabética constituye la manifestación extrema del déficit de insulina caracterizada por deshidratación, hiperglicemia, acidosis y cetosis. El tratamiento incluye soporte vital básico, hidratación parenteral para reposición de líquidos y electrolitos, insulinoterapia, con el objetivo de revertir la acidosis, la cetosis y obtener glucemia cercanas a lo normal. Exige un monitoreo estricto clínico y laboratorial siguiendo guías de manejo para evitar complicaciones y obtener una evolución favorable. Se presentan las modificaciones en las directrices publicadas en el Primer Consenso de diagnóstico y tratamiento de la Cetoacidosis diabética, en base a las actualizaciones sugeridas por la ISPAD (International Society of Pediatric and Adolescent Diabetes) y el Programa de Diabetes del Ministerio de Salud Pública y Bienestar Social (MSPBS).]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract Diabetic ketoacidosis is caused by extreme insulin deficiency and is characterized by dehydration, hyperglycemia, acidosis, and ketosis. Treatment includes basic life support, parenteral hydration to replace fluids and electrolytes and insulin therapy to reverse acidosis, ketosis, and normalize blood glucose levels. Management requires following guidelines for strict clinical and laboratory monitoring to avoid complications and obtain a favorable clinical outcome. The guidelines published in our previous Consensus on Diabetic Ketoacidosis diagnosis and treatment are presented, modified according to the latest changes in ISPAD (International Society of Pediatric and Adolescent Diabetes) and the Ministry of Public Health and Social Welfare Diabetes Program guidelines.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cetoacidosis diabética]]></kwd>
<kwd lng="es"><![CDATA[diabetes tipo 1.]]></kwd>
<kwd lng="en"><![CDATA[Diabetic ketoacidosis]]></kwd>
<kwd lng="en"><![CDATA[type 1 diabetes]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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