<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1683-9803</journal-id>
<journal-title><![CDATA[Pediatría (Asunción)]]></journal-title>
<abbrev-journal-title><![CDATA[Pediatr. (Asunción)]]></abbrev-journal-title>
<issn>1683-9803</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Pediatría]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1683-98032018000200141</article-id>
<article-id pub-id-type="doi">10.31698/ped.45022018006</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Deficiencias de anticuerpos en niños y adolescentes con infecciones recurrentes y/o graves]]></article-title>
<article-title xml:lang="en"><![CDATA[Antibody deficiencies in children and adolescents with recurrent and/or severe infections]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Caballero]]></surname>
<given-names><![CDATA[Fabiola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Benegas]]></surname>
<given-names><![CDATA[Sara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Giménez]]></surname>
<given-names><![CDATA[Vivian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Granado]]></surname>
<given-names><![CDATA[Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez de Cuellar]]></surname>
<given-names><![CDATA[Celia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carpinelli]]></surname>
<given-names><![CDATA[María Mercedes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sanabria]]></surname>
<given-names><![CDATA[Diana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Instituto de Investigaciones en Ciencias de la Salud Departamento de Inmunología]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas ]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2018</year>
</pub-date>
<volume>45</volume>
<numero>2</numero>
<fpage>141</fpage>
<lpage>146</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S1683-98032018000200141&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S1683-98032018000200141&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S1683-98032018000200141&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  Las deficiencias predominantes de anticuerpos (DPA) son inmunodeficiencias primarias caracterizadas por hipogammaglobulinemia, una disminución de niveles séricos de IgA, IgG y/o IgM, predisponiendo a infecciones recurrentes y/o graves. Las más frecuentes son la inmunodeficiencia común variable (CVID), agammaglobulinemia ligada al X (XLA), síndrome de híper IgM (HIgM) y deficiencia de IgA (DIgA). En Paraguay, los reportes sobre estas patologías son escasos.  Objetivo:  estudiar los niveles de inmunoglobulinas séricas en pacientes con infecciones recurrentes y/o graves en busca de DPA.  Material y Métodos:  Se incluyeron 143 pacientes de 1 a 17 años de edad, registrados en la base de datos del Instituto de Investigaciones en Ciencias de la Salud del 2012 al 2017, con dosajes de IgA, IgG e IgM y dato clínico de infecciones recurrentes y/o graves. Se aplicó un algoritmo internacional de diagnóstico fenotípico a los casos de hipogammaglobulinemia.  Resultados:  La edad promedio de los pacientes fue de 6±4 años, 54% (77/143) era de sexo masculino, un 78% (112/143) fue pacientes ambulatorios y 40% (57/143) presentó infecciones respiratorias. En el 90% (129/143) se observó valores normales de inmunoglobulinas séricas y en el 10% (14/143) se encontró hipogammaglobulinemia que correspondió a un caso de XLA, 3 casos de CVID, 5 de DIgA, 2 de HIgM, 2 deficiencias de subclases de IgG y una deficiencia selectiva de IgM.  Conclusiones:  Se identificaron casos de DPA cuyas frecuencias concuerdan con datos de otros países con DIgA y CVID como las más comunes. Es importante sospecharlas en niños y adolescentes con infecciones recurrentes, graves, oportunistas, y evaluar las inmunoglobulinas séricas para un diagnóstico oportuno.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Predominantly antibody deficiencies (PAD) are primary immunodeficiencies characterized by hypogammaglobulinaemia, a decrease of IgA, IgG and/or IgM serum levels, which predispose to recurrent and/or severe infections. The most frequent are the common variable immunodeficiency (CVID), X-linked agammaglobulinaemia (XLA), hyper IgM syndrome (HIgM) and IgA deficiency (IgAD). In Paraguay, the reports about these diseases are very few.  Objective:  to study serum immunoglobulin levels in patients with recurrent and/or severe infections searching for PAD.  Materials and Methods:  143 patients from 1 to 17 years old were included, registered in a data base from the Instituto de Investigaciones en Ciencias de la Salud from 2012 to 2017, with IgA, IgG and IgM serum levels dosages and clinical reference of recurrent and/or severe infections. An international diagnostic phenotypic algorithm was applied to the hypogammaglobulinaemia cases.  Results:  The average age of the patients was 6 ± 4 years, 54% (77/143) were males, 78% (112/143) were outpatients and 40% (57/143) had respiratory infections. In 90% (129/143) of the patients normal values of serum immunoglobulins were observed and in 10% (14/143) hypogammaglobulinaemia was found, corresponding to one case of XLA, 3 cases of CVID, 5 of IgAD, 2 of HIgM, 2 IgG subclasses deficiencies and one IgM selective deficiency.  Conclusions:  The frequency of DPA cases identified corresponds with data from other countries in which IgAD and CVID are the most common ones. It is important to suspect these pathologies in children and adolescents with recurrent, severe, opportunistic infections and evaluate their serum immunoglobulins for timely diagnostic.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Deficiencias de anticuerpos]]></kwd>
<kwd lng="es"><![CDATA[hipogammaglobulinemia]]></kwd>
<kwd lng="es"><![CDATA[inmunodeficiencias primarias]]></kwd>
<kwd lng="en"><![CDATA[Antibody deficiencies]]></kwd>
<kwd lng="en"><![CDATA[hypogammaglobulinaemia]]></kwd>
<kwd lng="en"><![CDATA[primary immunodeficiencies.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Notarangelo]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Casanova]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Conley]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Chapel]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Fischer]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Puck]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Primary immunodeficiency diseases an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee Meeting in Budapest, 2005]]></article-title>
<source><![CDATA[J Allergy Clin Immunol]]></source>
<year>2006</year>
<volume>117</volume>
<page-range>883-96</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Boyle]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Buckley]]></surname>
<given-names><![CDATA[RH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Population Prevalence of Diagnoset Primary Immunodeficiency Diseases in the United Stated]]></article-title>
<source><![CDATA[J Clin Immunol,]]></source>
<year>2007</year>
<volume>27</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>497-502</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Picard]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Gaspar]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Al-Herz]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Bousfihas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Casanova]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[International Union of Immunological Societies 2017 Primary Imnodeficiency Diseases Committee report on Inborn of Immunity]]></article-title>
<source><![CDATA[J Clin Immunol]]></source>
<year>2018</year>
<volume>38</volume>
<page-range>96-128</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Torabi Sagvand]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Mirminachi]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Abolhassani]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Shokouhfar]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Keihanian]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Amirzargar]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[IgG anti-IgA antibodies in pediatric antibody-deficient patients receiving intravenous immunoglobulin]]></article-title>
<source><![CDATA[Allergol Immunopathol (Madr)]]></source>
<year>2015</year>
<volume>4</volume>
<numero>43</numero>
<issue>43</issue>
<page-range>403-8</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Conley]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[Notarangelo]]></surname>
<given-names><![CDATA[LD]]></given-names>
</name>
<name>
<surname><![CDATA[Etzioni]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diagnostic Criteria for Primary Immunodeficiencies]]></article-title>
<source><![CDATA[Clin immunol]]></source>
<year>1999</year>
<volume>93</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>190-7</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bousfiha]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Jeddane]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Al-Herz]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Ailal]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Casanova]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Chatila]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies]]></article-title>
<source><![CDATA[J ClinImmunol]]></source>
<year>2015</year>
<volume>35</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>727-38</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bousfiha]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Jeddane]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Picard]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Ailal]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Chatila]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Crow]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies]]></article-title>
<source><![CDATA[J Clin Immunol]]></source>
<year>2018</year>
<volume>38</volume>
<page-range>129-43</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Martinez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Picagua]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Carpinelli]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Rovira]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Gimenez]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of serum immunoglobulin levels in children with repetitive pneumonias]]></article-title>
<source><![CDATA[Mem Inst Investig En Cienc Salud]]></source>
<year>2009</year>
<volume>7</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>21-15</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferreira]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Picaguá]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Carpinelli]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Rovira]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Giménez]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serum Immunoglobulin Levels in Children with Recurrent Infections]]></article-title>
<source><![CDATA[Pediatr. (Asunción)]]></source>
<year>2010</year>
<volume>37</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>123-6</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ballow]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Notarangelo]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Grimbacher]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Cunningham-Rundles]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Stein]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Helbert]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Immunodeficiencies]]></article-title>
<source><![CDATA[Clin Exp Immunol]]></source>
<year>2009</year>
<volume>58</volume>
<page-range>14-22</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Whelan]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Hwan]]></surname>
<given-names><![CDATA[WH]]></given-names>
</name>
<name>
<surname><![CDATA[Beausoleil]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Hauck]]></surname>
<given-names><![CDATA[WW]]></given-names>
</name>
<name>
<surname><![CDATA[McGeady]]></surname>
<given-names><![CDATA[SJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Infants presenting with recurrent infections and low immunoglobulins characteristics and analysis of normalization]]></article-title>
<source><![CDATA[J Clin Immunol]]></source>
<year>2006</year>
<volume>26</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>7-11</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bonilla]]></surname>
<given-names><![CDATA[FA]]></given-names>
</name>
<name>
<surname><![CDATA[Khan]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[Ballas]]></surname>
<given-names><![CDATA[ZK]]></given-names>
</name>
<name>
<surname><![CDATA[Chinen]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Frank]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Hsu]]></surname>
<given-names><![CDATA[JT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Practice parameter for the diagnosis and management of primary immunodeficiency]]></article-title>
<source><![CDATA[J AllergyClin Immunol]]></source>
<year>2015</year>
<volume>136</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1186-205</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Stoop]]></surname>
<given-names><![CDATA[JW]]></given-names>
</name>
<name>
<surname><![CDATA[Zegers]]></surname>
<given-names><![CDATA[BJ]]></given-names>
</name>
<name>
<surname><![CDATA[Sander]]></surname>
<given-names><![CDATA[PC]]></given-names>
</name>
<name>
<surname><![CDATA[Ballieux]]></surname>
<given-names><![CDATA[RE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serum Immunoglobulin levels in Healthy Childern and Adults Clin. exp]]></article-title>
<source><![CDATA[Immunol]]></source>
<year>1969</year>
<volume>4</volume>
<page-range>101-12</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Steihm]]></surname>
<given-names><![CDATA[ER]]></given-names>
</name>
<name>
<surname><![CDATA[Fudemberg]]></surname>
<given-names><![CDATA[HH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Serum levels of Immunoglobulins in health and disease. A survey]]></article-title>
<source><![CDATA[Pediatrics]]></source>
<year>1966</year>
<page-range>715-7727</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Saltter]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Gennery]]></surname>
<given-names><![CDATA[AR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical Immunology Review Series An approach to the patient with recurrent infections in childhood]]></article-title>
<source><![CDATA[Clin Exp Immunol]]></source>
<year>2008</year>
<volume>152</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>389-96</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sanabria]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Giménez]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Carpinelli]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estallido respiratorio de neutrófilos por las técnicas del nitroazul tetrazolio (NBT) y dihidrorodamina (DHR) en niños con sospecha clínica de enfermedad granulomatosa crónica (EGC)]]></article-title>
<collab>Martínez de Cuellar C</collab>
<source><![CDATA[Pediatr. (Asunción)]]></source>
<year>2017</year>
<volume>44</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>49-55</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Fundora]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Notario]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rabaza]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Factores de riesgo inmunoepidemiológicos en niños con infecciones respiratorias recurrentes]]></article-title>
<source><![CDATA[Revista Cubana de Pediatría]]></source>
<year>2011</year>
<volume>83</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>225-35</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ogershok]]></surname>
<given-names><![CDATA[PR]]></given-names>
</name>
<name>
<surname><![CDATA[Hogan]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Welch]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Corder]]></surname>
<given-names><![CDATA[WT]]></given-names>
</name>
<name>
<surname><![CDATA[Wilson]]></surname>
<given-names><![CDATA[NW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Spectrum of illness in pediatric common variable immunodeficiency]]></article-title>
<source><![CDATA[Asthma Immunol]]></source>
<year>2006</year>
<volume>97</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>653-6</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Quinti]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Soresina]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Spadaro]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Martino]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Donnanno]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Agostini]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency]]></article-title>
<source><![CDATA[J Clin Immunol]]></source>
<year>2007</year>
<volume>27</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>308-16</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rojas-Torres]]></surname>
<given-names><![CDATA[DS]]></given-names>
</name>
<name>
<surname><![CDATA[Bastidas-Yaguana]]></surname>
<given-names><![CDATA[DK]]></given-names>
</name>
<name>
<surname><![CDATA[Sierra-Santos]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Aguilar-Shea]]></surname>
<given-names><![CDATA[AL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Importancia del déficit selectivo de inmunoglobulina A]]></article-title>
<source><![CDATA[Semergen]]></source>
<year>2014</year>
<volume>40</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>e65-8</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
