<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2664-2891</journal-id>
<journal-title><![CDATA[Revista científica ciencias de la salud]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. cient. cienc. salud]]></abbrev-journal-title>
<issn>2664-2891</issn>
<publisher>
<publisher-name><![CDATA[Universidad del Pacífico]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2664-28912026000100232</article-id>
<article-id pub-id-type="doi">10.53732/rccsalud/2026.e81109</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Características clínicas, manejo y desenlaces de la colangitis aguda en un hospital universitario paraguayo, 2022-2025]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical characteristics, management, and outcomes of acute cholangitis in a Paraguayan university hospital, 2022-2025]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández Escobar]]></surname>
<given-names><![CDATA[Neil Nelson]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas ]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<volume>8</volume>
<fpage>232</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2664-28912026000100232&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2664-28912026000100232&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2664-28912026000100232&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción. La colangitis aguda es una infección del árbol biliar asociada con obstrucción del flujo biliar y puede progresar a sepsis y disfunción orgánica.  Objetivo. Describir las características clínicas, la etiología, el diagnóstico, el tratamiento y los desenlaces intrahospitalarios de pacientes con colangitis aguda atendidos en un hospital universitario paraguayo.  Materiales y método. Estudio observacional, descriptivo y retrospectivo de pacientes adultos hospitalizados entre enero de 2022 y octubre de 2025. Se aplicó estadística descriptiva.  Resultados. Se incluyeron 28 pacientes; la edad media fue de 57,8 ± 11,3 años y 17 (60,7%) eran hombres. La etiología litiásica fue la más frecuente (15; 53,6%). La colangitis fue leve en 11 (39,3%), moderada en 10 (35,7%) y grave en 7 (25,0%). Se realizó CPRE en 13 pacientes (46,4%), con éxito terapéutico en 9 (69,2%); 15 (53,6%) requirieron cirugía. Se registró un fallecimiento intrahospitalario (3,6%).  Conclusión. La etiología litiásica predominó y más de la mitad de los pacientes requirió cirugía. Los hallazgos respaldan la estandarización del manejo según la gravedad y la evaluación del acceso oportuno al drenaje endoscópico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction. Acute cholangitis is an infection of the biliary tree associated with bile-flow obstruction and may progress to sepsis and organ dysfunction.  Objective. To describe the clinical characteristics, etiology, diagnostic assessment, treatment, and in-hospital outcomes of patients with acute cholangitis treated at a Paraguayan university hospital.  Materials and methods. Observational, descriptive, retrospective study of adult patients hospitalized between January 2022 and October 2025. Descriptive statistics were used.  Results. Twenty-eight patients were included; mean age was 57.8 ± 11.3 years, and 17 (60.7%) were men. Lithiasic disease was the most frequent etiology (15; 53.6%). Cholangitis was mild in 11 (39.3%), moderate in 10 (35.7%), and severe in 7 (25.0%). ERCP was performed in 13 patients (46.4%), with therapeutic success in 9 (69.2%); 15 (53.6%) required surgery. One in-hospital death occurred (3.6%).  Conclusion. Lithiasic disease predominated, and more than half of the patients required surgery. These findings support standardized severity-based management and institutional evaluation of timely access to endoscopic drainage.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[colangitis]]></kwd>
<kwd lng="es"><![CDATA[coledocolitiasis]]></kwd>
<kwd lng="es"><![CDATA[drenaje biliar]]></kwd>
<kwd lng="es"><![CDATA[colangiopancreatografía retrógrada endoscópica]]></kwd>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[cholangitis]]></kwd>
<kwd lng="en"><![CDATA[choledocholithiasis]]></kwd>
<kwd lng="en"><![CDATA[biliary drainage]]></kwd>
<kwd lng="en"><![CDATA[cholangiopancreatography, endoscopic retrograde]]></kwd>
</kwd-group>
</article-meta>
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