<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2413-4341</journal-id>
<journal-title><![CDATA[Revista Paraguaya de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. parag. reumatol.]]></abbrev-journal-title>
<issn>2413-4341</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Reumatología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2413-43412021000200060</article-id>
<article-id pub-id-type="doi">10.18004/rpr/2021.07.02.60</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Características clínicas e inmunológicas de los pacientes con esclerodermia que acudieron al Hospital Nacional de Itauguá durante el período 2018-2020]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical and immunological characteristics of patients with scleroderma who attended the Hospital Nacional de Itauguá from 2018-2020]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rolón]]></surname>
<given-names><![CDATA[Julio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sobarzo]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Ministerio de Salud Pública y Bienestar Social Centro Médico Nacional, Hospital Nacional Departamento de Medicina Interna]]></institution>
<addr-line><![CDATA[Itauguá ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Itapúa Facultad de Medicina Postgrado en Medicina Interna]]></institution>
<addr-line><![CDATA[Encarnación ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>7</volume>
<numero>2</numero>
<fpage>60</fpage>
<lpage>65</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2413-43412021000200060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2413-43412021000200060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2413-43412021000200060&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen: Introducción: La esclerodermia o esclerosis sistémica (ES) es una enfermedad de causa desconocida, generalizada del tejido conectivo, que ocasiona fibrosis y alteraciones degenerativas a nivel de la piel, la membrana sinovial, los vasos arteriales, el músculo esquelético, tracto gastrointestinal, pulmón, corazón y riñón. Objetivos: Describir las características clínicas e inmunológicas de pacientes con esclerodermia sistémica tanto internados como ambulatorios que acudieron al Hospital Nacional de Itauguá, 2018-2020. Metodología: Se realizó un estudio observacional descriptivo de corte transversal, muestreo no probabilístico de conveniencia. Se incluyó a pacientes varones y mujeres, mayores de 18 años de edad, portadores de esclerodermia, que acuden en el Hospital Nacional en el periodo desde enero del 2018 hasta octubre 2020. Se midieron variables sociodemográficas, clínicas, laboratoriales y tratamiento recibido. Se respetaron los aspectos éticos. Resultados: La muestra estuvo constituida por 34 pacientes, siendo la media de 48±13 años, la mayoría provenían del departamento Central, predominando el sexo femenino 65%. La manifestación clínica más frecuente fue el fenómeno de Raynaud en 88%, la forma clínica predominante fue la esclerodermia difusa 56%, con mayor afectación a nivel cardiovascular y pulmonar con 53% y 50% respectivamente. Se observaron anticuerpos anti-Topoisomerasa l en el 50% y anticuerpo anti-centrómero en el 12% de los pacientes con esclerodermia y el tratamiento más utilizado fue corticoide (53%). Conclusión: En la esclerodermia prevalecieron los adultos jóvenes y del sexo femenino. Como manifestación clínica más frecuente el fenómeno de Raynaud, con predominancia clínica de la forma difusa, con afectación de diferentes órganos internos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract: Introduction: Scleroderma or systemic sclerosis (SS) is a systemic connective tissue disease of unknown cause, that causes fibrosis and degenerative changes in the skin, synovial membrane, arterial vessels, skeletal muscle, gastrointestinal tract, lung, heart and kidney. Objectives: To describe the clinical and immunological characteristics of inpatients and outpatients with systemic sclerosis who attended the National Hospital of Itaguá from 2018-2020. Methodology: A descriptive, cross-sectional observational study was carried out with nonprobabilistic convenience sampling. Male and female patients, 18 years or older, with scleroderma, who attended the National Hospital in the period from January 2018 to October 2020, were included. Socio demographic, clinical, and laboratory variables as well as treatment, were recorded. Ethical aspects were taken into account. Results: The sample consisted of 34 patients. The mean age was 48 ± 13 years. Most patients were from the Central department, and predominantly female (65%). The most frequent clinical manifestation was Raynaud&#8216;s phenomenon (88%), and the predominant clinical form was diffuse scleroderma (56%). Most frequently affected organs were the cardiovascular (53%) and pulmonary systems (50%). Anti-Topoisomerase I antibodies were observed in 50% and anti-Centromere antibody in 12% of the patients with scleroderma. Most frequently used treatment was corticosteroids (53%). Conclusion: Young adult females prevailed in this scleroderma population. The most frequent clinical form was diffuse scleroderma and Raynaud&#8216;s phenomenon was the most common symptom.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[esclerodermia]]></kwd>
<kwd lng="es"><![CDATA[características clínicas]]></kwd>
<kwd lng="es"><![CDATA[características inmunológicas]]></kwd>
<kwd lng="en"><![CDATA[scleroderma]]></kwd>
<kwd lng="en"><![CDATA[clinical features]]></kwd>
<kwd lng="en"><![CDATA[immunological features]]></kwd>
</kwd-group>
</article-meta>
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