<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2413-4341</journal-id>
<journal-title><![CDATA[Revista Paraguaya de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. parag. reumatol.]]></abbrev-journal-title>
<issn>2413-4341</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Reumatología]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2413-43412019000100013</article-id>
<article-id pub-id-type="doi">10.18004/rpr/2019.05.01.13-19</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Determinación del estado de crecimiento, niveles de factor de crecimiento insulínico tipo 1 (IGF-1) y vitamina D en pacientes con artritis idiopática juvenil tratados en el Hospital Materno Infantil ISSEMYM en Toluca de Lerdo, México]]></article-title>
<article-title xml:lang="en"><![CDATA[Determination of growth status, levels of insulin growth factor type 1 (IGF-1) and vitamin D in patients with juvenile idiopathic arthritis treated at the IssemYm maternal and Child Hospital in Toluca de Lerdo, Mexico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zeron]]></surname>
<given-names><![CDATA[Samara Mendieta]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marín]]></surname>
<given-names><![CDATA[Katherine Henao]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Materno Infantil ISSEMYM  ]]></institution>
<addr-line><![CDATA[Toluca ]]></addr-line>
<country>México</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Institución Universitaria Colegio Mayor de Antioquia  ]]></institution>
<addr-line><![CDATA[Medellín ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<volume>5</volume>
<numero>1</numero>
<fpage>13</fpage>
<lpage>19</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2413-43412019000100013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2413-43412019000100013&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2413-43412019000100013&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Antecedentes: En la artritis idiopática juvenil (AIJ) se ha descrito el retraso en el crecimiento de los niños, la vitamina D y el factor de crecimiento insulínico tipo 1 (IGF-1) se han reportado disminuidos en esta enfermedad y al parecer forman parte del inadecuado desarrollo óseo y posterior retraso que se presenta. Objetivo: Determinar el estado de crecimiento en pacientes con AIJ, los niveles de IGF-1 y vitamina D y su relación según el tipo de AIJ que presentan, el tratamiento que reciben, el tiempo de evolución con la patología, la edad, y el género de cada paciente. Métodos: Este estudio de cohorte, se incluyeron 13 niños con AIJ. Los pacientes asistieron a una visita ambulatoria entre febrero y mayo de 2019 para ser evaluados a nivel clínico, antropométrico y se recolectó suero para la determinación de vitamina D [25(OH)D], IGF-1 y PTH utilizando el método de inmunoensayo quimioluminiscente. Además, se utilizaron curvas de crecimiento adecuadas por la CDC para determinar el estado de los pacientes. Resultados y discusión: Se observa la insuficiencia de vitamina D en el 84,62% de los pacientes incluyendo los que presentan retraso en el crecimiento (15,38%), según diversos autores esta puede ser una causa de tal retraso, pero nuestro estudio no puede concluirlo; el IGF-1 está normal en todos los pacientes. El uso de corticosteroides, el tiempo de evolución, el tipo de AIJ o tratamiento, edad y género no se ven implicados como un cofactor para el retraso en el crecimiento. Conclusión: El retraso en el crecimiento se encontró en el 15,38% de los pacientes, se identificó la marcada insuficiencia de la vitamina D en pacientes con AIJ, se sugieren más estudios que puedan correlacionar diferentes variables con tal déficit.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Introduction: Growth delay has been described in children with juvenile idiopathic arthritis (JIA). Low vitamin D and insulin growth factor type 1 ( IGF-1) have been reported in this disease and seem to be related to the inadequete bone development and subsequent growht delay. Objetive: To determine growth status, levels of IGF-1, and Vitamin D in patients with JIA, acording to JIA subtype, received treatment, disease duration, age and gender of each patient. methods: Thirteen (13) children with JIA were included in this cohort sutdy . Patients were seen on an ambulatory basis from february through may of 2019. They recevied a clinical and anthropometric evaluation and serum was collected for Vitamin D[25(OH)D], IGF-1 and PTH measurement through chemiluminescent immunoessays. Growth charts approved by the CDC were also used to determine the patients&#8217; growth status. Results and discussion: Vitamin D insuficiency was observed in 84,62% of patients, including those wiht growth delay (15,38%). Accordin to different authors, this could be a cause of such delay, but we are unable to draw conclusions with this study. Insulin growth factor 1 (IGF-1) was normal in all patients. Use of corticosteroids, disease duration, JIA subtype or treatment, age and gender were not found to be implicated as risk factors for growth delay. Conclusion: Growth delay was found in 15,38% of the patientes. Significant Vitamin D insuficiency was identified in patients with JIA, which suggest that further studies might identify variables that might correlated with this deficit.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Artritis idiopática juvenil (AIJ)]]></kwd>
<kwd lng="es"><![CDATA[factor de crecimiento insulínico tipo 1 (IGF-1)]]></kwd>
<kwd lng="es"><![CDATA[vitamina D]]></kwd>
<kwd lng="es"><![CDATA[Parathormona (PTH)]]></kwd>
<kwd lng="es"><![CDATA[crecimiento]]></kwd>
<kwd lng="en"><![CDATA[Juvenile idiopathic arthritis (JIA)]]></kwd>
<kwd lng="en"><![CDATA[insulin growth factor type 1 (IGF-1)]]></kwd>
<kwd lng="en"><![CDATA[vitamin D]]></kwd>
<kwd lng="en"><![CDATA[parathyroid hormone (PTH)]]></kwd>
<kwd lng="en"><![CDATA[growth]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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