<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2409-8752</journal-id>
<journal-title><![CDATA[Revista Científica de la UCSA]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. ciente. UCSA]]></abbrev-journal-title>
<issn>2409-8752</issn>
<publisher>
<publisher-name><![CDATA[Universidad del Cono Sur de las Américas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2409-87522026000100073</article-id>
<article-id pub-id-type="doi">10.18004/ucsa/2409-8752/2026.013.01.073</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Deshidratación y oxidación térmica híbrida solar-eléctrica de hojas de Cannabis sativa L. Prospección de la concentración de CBD, THC y CBN]]></article-title>
<article-title xml:lang="en"><![CDATA[Hybrid solar-electric thermal dehydration and oxidation of Cannabis sativa L. leaves. Prospecting of CBD, THC and CBN concentration]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sequeira]]></surname>
<given-names><![CDATA[Alfredo Fabián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Spotorno]]></surname>
<given-names><![CDATA[Rubén Ángel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pochettino]]></surname>
<given-names><![CDATA[Juan José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Delfino]]></surname>
<given-names><![CDATA[Mario Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morales]]></surname>
<given-names><![CDATA[Walter Gustavo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Tecnológica Nacional  ]]></institution>
<addr-line><![CDATA[Resistencia ]]></addr-line>
<country>Argentina</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Tecnológica Nacional  ]]></institution>
<addr-line><![CDATA[Resistencia ]]></addr-line>
<country>Argentina</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional del Nordeste  ]]></institution>
<addr-line><![CDATA[Corrientes ]]></addr-line>
<country>Argentina</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2026</year>
</pub-date>
<volume>13</volume>
<numero>1</numero>
<fpage>73</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2409-87522026000100073&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2409-87522026000100073&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2409-87522026000100073&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN En el presente trabajo se presenta el proceso de deshidratación y oxidación térmica híbrido (solar-eléctrico) aplicado a hojas de Cannabis sativa L., un residuo usual de la cannabicultura. El estudio elabora la búsqueda de la viabilidad de utilizar las hojas como materia prima, evaluando la concentración de Cannabidiol (CBD), Tetrahidrocannabinol (THC) y Cannabinol (CBN). Los ensayos realizados permitieron determinar que el tratamiento térmico, no solo elimina la humedad, sino que también induce transformaciones químicas deseables, particularmente la degradación oxidativa del THC a CBN, mientras se preserva el CBD. Se determinó que el proceso se divide en dos fases distintas: una etapa de deshidratación de 5 a 6 horas de duración, seguida de una etapa de oxidación térmica. Los resultados cuantitativos son significativos: las hojas frescas con 12 mg/g de CBD, alcanzan concentraciones de hasta 53,05 mg/g de CBD tras 30 horas de tratamiento de deshidratación y oxidación térmica. Esto revela un potencial económico sustancial, estableciendo que el descarte de hojas implica una pérdida de compuestos activos en una relación estimada de 1:4 (gramos de CBD en ápices florales respecto a gramos de CBD en hojas tratadas). La investigación concluye que este método representa una estrategia eficaz para la valorización de residuos, mejorando la sostenibilidad y la rentabilidad de la producción de cannabis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT This study presents a hybrid thermal dehydration and oxidation process (solar-electric) applied to Cannabis sativa L. leaves, a common by-product of cannabis cultivation. The research aims to assess the viability of utilizing the leaves as raw material by quantifying the concentration of Cannabidiol (CBD), Tetrahydrocannabinol (THC), and Cannabinol (CBN). Experimental trials revealed that the thermal treatment not only effectively removes moisture but also induces desirable chemical transformations, particularly the oxidative degradation of THC to CBN while successfully preserving the CBD. The process was determined to comprise two distinct stages: an initial dehydration phase lasting 5 to 6 hours, followed by a final thermal oxidation phase. The quantitative results are significant: fresh leaves, initially containing 12 mg/g of CBD, reached final concentrations of up to 53.05 mg/g of CBD after 30 hours of thermal dehydration and oxidation treatment. This outcome suggests a substantial economic potential, as discarding the leaves implies a significant loss of active compounds, estimated at a 1:4 ratio (grams of CBD in floral apices relative to grams of CBD in treated leaves). Ultimately, this method is concluded to be an effective strategy for waste valorisation, thereby enhancing the sustainability and profitability of cannabis production.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cannabis sativa L.]]></kwd>
<kwd lng="es"><![CDATA[secado híbrido]]></kwd>
<kwd lng="es"><![CDATA[cannabinoides bioactivos]]></kwd>
<kwd lng="en"><![CDATA[Cannabis sativa L.]]></kwd>
<kwd lng="en"><![CDATA[hybrid dehydration]]></kwd>
<kwd lng="en"><![CDATA[bioactive cannabinoids]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Challa]]></surname>
<given-names><![CDATA[S. K. R]]></given-names>
</name>
<name>
<surname><![CDATA[Misra]]></surname>
<given-names><![CDATA[N. N]]></given-names>
</name>
<name>
<surname><![CDATA[Martynenko]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drying of cannabis&#8212;state of the practices and future needs]]></article-title>
<source><![CDATA[Drying Technology]]></source>
<year>2021</year>
<volume>39</volume>
<numero>14</numero>
<issue>14</issue>
<page-range>2055-64</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chasiotis]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Tsakirakis]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Termentzi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Machera]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Filios]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drying and quality characteristics of Cannabis sativa L.]]></article-title>
<source><![CDATA[inflorescences under constant and time-varying convective drying temperature schemes. Thermal Science and Engineering Progress]]></source>
<year>2022</year>
<volume>28</volume>
<page-range>101076</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García-Tejero]]></surname>
<given-names><![CDATA[I. F]]></given-names>
</name>
<name>
<surname><![CDATA[Durán Zuazo]]></surname>
<given-names><![CDATA[V. H]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez-Carnenero]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ferreiro-Vera]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Casano]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Seeking suitable agronomical practices for industrial hemp (Cannabis sativa L.) cultivation for biomedical applications]]></article-title>
<source><![CDATA[Industrial Crops and Products]]></source>
<year>2019</year>
<volume>139</volume>
<page-range>111524</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Dai]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Xie]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Cheng]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Secondary Metabolites Profiled in Cannabis Inflorescences, Leaves, Stem Barks, and Roots for Medicinal Purposes]]></article-title>
<source><![CDATA[Scientific Reports]]></source>
<year>2020</year>
<volume>10</volume>
<page-range>3309</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kanabus]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Bry&#322;a]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Roszko]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of selected drying methods on the cannabinoid profile of Cannabis sativa L.]]></article-title>
<source><![CDATA[var. sativa inflorescences and leaves. Polish Journal of Food and Nutrition Sciences]]></source>
<year>2024</year>
<volume>74</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>408-18</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Milay]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Berman]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Shapira]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Guberman]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Meiri]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Metabolic Profiling of Cannabis Secondary Metabolites for Evaluation of Optimal Postharvest Storage Conditions]]></article-title>
<source><![CDATA[Frontiers in Plant Science]]></source>
<year>2020</year>
<volume>11</volume>
<page-range>583605</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nagy]]></surname>
<given-names><![CDATA[D. U]]></given-names>
</name>
<name>
<surname><![CDATA[Cianfaglione]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Maggi]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Sut]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Dall'Acqua]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chemical Characterization of Leaves, Male and Female Flowers from Spontaneous Cannabis (Cannabis sativa L.) Growing in Hungary]]></article-title>
<source><![CDATA[Chemistry &amp; Biodiversity]]></source>
<year>2019</year>
<volume>16</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Small]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evolution and Classification of Cannabis sativa (Marijuana, Hemp) in Relation to Human Utilization]]></article-title>
<source><![CDATA[The Botanical Review]]></source>
<year>2015</year>
<volume>81</volume>
<page-range>189-294</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Spotorno]]></surname>
<given-names><![CDATA[R. A]]></given-names>
</name>
<name>
<surname><![CDATA[Pochettino]]></surname>
<given-names><![CDATA[J. J]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Veppo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Sequeira]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Desarrollo y automatización de un secadero solar para vegetales y productos elaborados de alimentación fisiológica saludable]]></article-title>
<source><![CDATA[Extensionismo, Innovación y Transferencia Tecnológica, 9(2), 45&#8211;60]]></source>
<year>2024</year>
<volume>9</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>45-60</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Spotorno]]></surname>
<given-names><![CDATA[R. Á]]></given-names>
</name>
<name>
<surname><![CDATA[Pochettino]]></surname>
<given-names><![CDATA[J. J]]></given-names>
</name>
<name>
<surname><![CDATA[Sosa]]></surname>
<given-names><![CDATA[C. A]]></given-names>
</name>
<name>
<surname><![CDATA[Sequeira]]></surname>
<given-names><![CDATA[A. F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Secado solar con control de temperatura de aire de vegetales y productos elaborados de alimentación fisiológica saludable]]></article-title>
<source><![CDATA[Revista Científica de la UCSA]]></source>
<year>2025</year>
<volume>12</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>3-14</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[White]]></surname>
<given-names><![CDATA[C. M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A Review of Human Studies Assessing Cannabidiol's (CBD) Therapeutic Actions and Potential]]></article-title>
<source><![CDATA[The Journal of Clinical Pharmacology]]></source>
<year>2019</year>
<volume>59</volume>
<page-range>923-34</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zuardi]]></surname>
<given-names><![CDATA[A. W]]></given-names>
</name>
<name>
<surname><![CDATA[Crippa]]></surname>
<given-names><![CDATA[J. A. S]]></given-names>
</name>
<name>
<surname><![CDATA[Hallak]]></surname>
<given-names><![CDATA[J. E. C]]></given-names>
</name>
<name>
<surname><![CDATA[Moreira]]></surname>
<given-names><![CDATA[F. A]]></given-names>
</name>
<name>
<surname><![CDATA[Guimarães]]></surname>
<given-names><![CDATA[F. S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug]]></article-title>
<source><![CDATA[Brazilian Journal of Medical and Biological Research]]></source>
<year>2006</year>
<volume>39</volume>
<page-range>421-9</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
