<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932026000100312</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2026.e13142612</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Prurito de difícil tratamiento, indicador precoz de neoplasia hematológica]]></article-title>
<article-title xml:lang="en"><![CDATA[Difficult-to-treat pruritus, an early indicator of hematological neoplasia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fleitas Goiriz]]></surname>
<given-names><![CDATA[Braulio Mauricio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Centurión Villalba]]></surname>
<given-names><![CDATA[Aramí María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rotela Fisch]]></surname>
<given-names><![CDATA[Verónica Rose Marie]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Giardina Varela]]></surname>
<given-names><![CDATA[Romylda Dalisse]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Goiburu Chenú]]></surname>
<given-names><![CDATA[María Belén]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flor Gonzalez]]></surname>
<given-names><![CDATA[Liz Marlene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aldama Caballero]]></surname>
<given-names><![CDATA[Arnaldo Benjamín Feliciano]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Hospital de Clínicas]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional de Asunción Facultad de Ciencias Médicas Hospital de Clínicas]]></institution>
<addr-line><![CDATA[San Lorenzo ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2026</year>
</pub-date>
<volume>13</volume>
<numero>1</numero>
<fpage>312</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932026000100312&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932026000100312&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932026000100312&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El prurito es una sensación desagradable que provoca el deseo de rascarse. Aunque frecuentemente se relaciona con enfermedades cutáneas primarias, en muchos casos puede ser la manifestación inicial, o incluso el único síntoma de una enfermedad sistémica. Las causas sistémicas más frecuentes son las enfermedades hematológicas y hepáticas. En este reporte se describe un caso de linfoma de Hodgkin, que se manifestó con prurito de larga data que no respondía a tratamientos convencionales. Se inició fototerapia como medicación antipruriginosa lográndose buena respuesta y mejoría del cuadro.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Pruritus is an unpleasant sensation that causes the urge to scratch. Although it is often associated with primary skin diseases, in many cases, it can be the initial manifestation or even the only symptom of a systemic disease. The most common systemic causes are hematological and liver diseases. This report describes a case of Hodgkin's lymphoma that presented with long-standing pruritus that did not respond to conventional treatments. Phototherapy was initiated as an antipruritic medication, achieving a good response and improvement of the condition.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[prurito]]></kwd>
<kwd lng="es"><![CDATA[enfermedad de Hodgkin]]></kwd>
<kwd lng="es"><![CDATA[fototerapia]]></kwd>
<kwd lng="en"><![CDATA[pruritus]]></kwd>
<kwd lng="en"><![CDATA[Hodgkin's disease]]></kwd>
<kwd lng="en"><![CDATA[phototherapy]]></kwd>
</kwd-group>
</article-meta>
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