<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932025000100301</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2025.e12132501</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Inercia terapéutica en el manejo de la hipertensión en adultos mayores: implicaciones clínicas]]></article-title>
<article-title xml:lang="en"><![CDATA[Therapeutic inertia in the management of hypertension in older adults: clinical implications]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carvajal Oviedo]]></surname>
<given-names><![CDATA[Cindy Julissa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Lovelo]]></surname>
<given-names><![CDATA[German Josué]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arboleda Núñez]]></surname>
<given-names><![CDATA[Julieth Vanessa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas Ortega]]></surname>
<given-names><![CDATA[Sebastián Danilo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Pacheco]]></surname>
<given-names><![CDATA[Yeives Paola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fajardo Alegría]]></surname>
<given-names><![CDATA[David Esteban]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Mendoza]]></surname>
<given-names><![CDATA[Luis Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortega Sierra]]></surname>
<given-names><![CDATA[Michael Gregorio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Santander Departamento de Medicina ]]></institution>
<addr-line><![CDATA[Bucaramanga ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Libre Departamento de Medicina ]]></institution>
<addr-line><![CDATA[Barranquilla ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Unidad Central del Valle del Cauca Facultad de Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[Tuluá ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Cooperativa de Colombia Departamento de Medicina ]]></institution>
<addr-line><![CDATA[Pasto ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Universidad Metropolitana Departamento de Medicina ]]></institution>
<addr-line><![CDATA[Barranquilla ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Fundación Universitaria San Martín Departamento de Medicina ]]></institution>
<addr-line><![CDATA[Pasto ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af7">
<institution><![CDATA[,Universidad Cooperativa de Colombia Departamento de Medicina ]]></institution>
<addr-line><![CDATA[Santa Marta ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af8">
<institution><![CDATA[,Universidad Centroccidental Lisandro Alvarado Hospital Central Antonio María Pineda ]]></institution>
<addr-line><![CDATA[Barquisimeto ]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2025</year>
</pub-date>
<volume>12</volume>
<numero>1</numero>
<fpage>301</fpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932025000100301&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932025000100301&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932025000100301&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Las enfermedades cardiovasculares siguen siendo la principal causa de morbilidad y mortalidad en el mundo, generando una carga de enfermedad importante en los sistemas de salud globales. La hipertensión arterial (HTA) es uno de los trastornos cardiovasculares más prevalentes en el mundo, estimándose más de 1 billón de casos a nivel global. Según datos de la Organización Mundial de la Salud, solo 2 de cada 10 personas con HTA se encuentran controlados, y uno de los objetivos de la salud global para el 2030, es reducir la prevalencia de HTA hasta en 33%. Esto puede ser causado por la omisión de intensificación de terapia farmacológica cuando se es necesario (inercia terapéutica). La inercia terapéutica es más frecuente en pacientes con alto riesgo de eventos secundarios o adversos, como lo son los adultos mayores. Se cree que este podría ser un potencial factor de riesgo de desenlaces cardiovasculares, con búsqueda de un cambio en algoritmos tradicionales y paradigmas controversiales. Sin embargo, persisten las discrepancias en la literatura respecto al abordaje de este tema. Considerando la relevancia de este y de la necesidad de conocer evidencia para cumplir con las metas de la salud global, el objetivo de esta revisión consistió en analizar críticamente la evidencia más reciente sobre la inercia terapéutica en el control de la presión arterial en adultos mayores.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Cardiovascular diseases continue to be the leading cause of morbidity and mortality in the world, generating a significant burden of disease in global health systems. Arterial hypertension (AHT) is one of the most prevalent cardiovascular disorders in the world, with more than 1 billion cases estimated globally. According to data from the World Health Organization, only 2 out of 10 people with HTN are under control, and one of the global health goals for 2030 is to reduce the prevalence of HTN by up to 33%. This may be caused by the omission to intensify drug therapy when necessary (therapeutic inertia). Therapeutic inertia is more frequent in patients at high risk of secondary or adverse events, such as older adults. It is believed that this could be a potential risk factor for cardiovascular outcomes, seeking a change in traditional algorithms and controversial paradigms. However, discrepancies persist in the literature regarding the approach to this topic. Considering its relevance and the need for evidence to meet global health goals, this review aimed to critically analyze the most recent evidence on therapeutic inertia in blood pressure control in older adults.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[presión arterial]]></kwd>
<kwd lng="es"><![CDATA[hipertensión]]></kwd>
<kwd lng="es"><![CDATA[anciano]]></kwd>
<kwd lng="es"><![CDATA[terapéutica]]></kwd>
<kwd lng="es"><![CDATA[factores de riesgo de enfermedad cardiaca]]></kwd>
<kwd lng="es"><![CDATA[cumplimiento y adherencia al tratamiento]]></kwd>
<kwd lng="en"><![CDATA[blood pressure]]></kwd>
<kwd lng="en"><![CDATA[hypertension]]></kwd>
<kwd lng="en"><![CDATA[elderly]]></kwd>
<kwd lng="en"><![CDATA[therapeutics]]></kwd>
<kwd lng="en"><![CDATA[risk factors for heart disease]]></kwd>
<kwd lng="en"><![CDATA[treatment compliance and adherence]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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