<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932021000200044</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2021.08.02.44</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Factores asociados a la mortalidad en pacientes con sepsis y choque séptico de la unidad de cuidados intensivos de adultos de un hospital de Paraguay]]></article-title>
<article-title xml:lang="en"><![CDATA[Factors associated with mortality in patients with sepsis and septic shock in the adult intensive care unit of a hospital in Paraguay]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escobar-Salinas]]></surname>
<given-names><![CDATA[Jorge Sebastián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortíz-Torres]]></surname>
<given-names><![CDATA[Sara Ester]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villalba-Viana]]></surname>
<given-names><![CDATA[Rocío Magalí]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Itapúa  ]]></institution>
<addr-line><![CDATA[Encarnación ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2021</year>
</pub-date>
<volume>8</volume>
<numero>2</numero>
<fpage>44</fpage>
<lpage>56</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932021000200044&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932021000200044&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932021000200044&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: la sepsis representa un problema de salud pública debido a su elevada mortalidad y la incidencia que va en aumento, en la cual se estima en 9% al año.  Objetivo:  analizar los factores asociados a la mortalidad en pacientes con sepsis y choque séptico del Servicio de cuidados intensivos adultos del Hospital Nacional, Itauguá, Paraguay, de enero 2019 a noviembre 2020.  Sujetos y Métodos:  estudio de casos y controles donde se incluyó a 57 pacientes (19 casos y 38 controles) con diagnóstico de sepsis y choque séptico.  Resultados:  se hallaron los siguientes factores de riesgo: edad mayor a 60 años (OR= 3,98; p&#8804;0,05), patología de base (OR= 18; p&#8804;0,05), internación mayor a 20 días (OR= 5,52; p&#8804;0,05), choque séptico (OR= 6,42; p&#8804;0,05), uso previo de antibióticos (OR= 0,45; p&#8805;0,05), retraso en el inicio de la antibioticoterapia (OR= 2,80; p&#8805;0,05), falla multiorgánica (OR= 9,44; p&#8804;0,05), lactato elevado (OR= 1,54; p&#8805;0,05), procalcitonina elevada (OR= 4,42; p&#8804;0,05), PCR elevado (OR= 5,58; p&#8805;0,05) y ventilación mecánica (OR= 6,42; p&#8805;0,05).  Conclusión:  se asociaron de manera significativa a la mortalidad la edad mayor a 60 años, ser portador de patología de base, internación en terapia intensiva mayor a 20 días, ingresar con choque séptico y con falla multiorgánica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Sepsis represents a public health problem due to its high mortality and increasing incidence, with an increase of 9% estimated per year.  Objective:  To analyze the factors associated with mortality in sepsis and septic shock patients in the adult intensive care unit of the National Hospital of Itauguá from January 2019 to November 2020.  Subjects and Methods:  Observational, analytical study of cases and controls that included 57 patients (19 cases and 38 controls) diagnosed with sepsis and septic shock.  Results:  The following risk factors were found: Age over 60 years (OR = 3.98; p&#8804;0.05), underlying pathology (OR = 18; p&#8804;0.05), hospitalization greater than 20 days (OR = 5.52; p&#8804;0.05), septic shock (OR = 6.42; p&#8804;0.05), previous use of antibiotics (OR = 0.45; p&#8805;0.05), delay in initiation of antibiotic therapy (OR = 2.80; p&#8805;0.05), multiple organ failure (OR = 9.44; p&#8804;0.05), elevated lactate (OR = 1.54; p&#8805;0.05), elevated procalcitonin (OR = 4.42; p&#8804;0.05), elevated CRP (OR = 5.58; p&#8805;0.05) and mechanical ventilation (OR = 6.42; p&#8805;0.05).  Conclusion:  Age over 60 years, being a carrier of an underlying pathology, hospitalization in intensive care for more than 20 days, entering septic shock, and admission with multiorgan failure were significantly associated with mortality.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[sepsis]]></kwd>
<kwd lng="es"><![CDATA[choque séptico]]></kwd>
<kwd lng="es"><![CDATA[cuidados críticos]]></kwd>
<kwd lng="es"><![CDATA[salud pública]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="en"><![CDATA[sepsis]]></kwd>
<kwd lng="en"><![CDATA[septic shock]]></kwd>
<kwd lng="en"><![CDATA[critical care]]></kwd>
<kwd lng="en"><![CDATA[public health]]></kwd>
<kwd lng="en"><![CDATA[mortality]]></kwd>
</kwd-group>
</article-meta>
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