<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932020000100010</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2020.07.01.10-019</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Intervalo QTc prolongado en pacientes de Clínica Médica: estudio multicéntrico]]></article-title>
<article-title xml:lang="en"><![CDATA[Prolonged QTc interval in patients of Clinical Medicine: multicenter study]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Roy]]></surname>
<given-names><![CDATA[Tatiana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peralta Giménez]]></surname>
<given-names><![CDATA[Ruth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gamarra Cardozo]]></surname>
<given-names><![CDATA[Lilian Celeste]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Núñez Vera]]></surname>
<given-names><![CDATA[Laura María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santacruz Sosa]]></surname>
<given-names><![CDATA[Micaela Carolina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alarcón Maciel]]></surname>
<given-names><![CDATA[Viviana Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sigmund Brítez]]></surname>
<given-names><![CDATA[Claudia Jazmín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Báez Correa]]></surname>
<given-names><![CDATA[Paola Magdalena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Comán González]]></surname>
<given-names><![CDATA[Janina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cristaldo Ramírez]]></surname>
<given-names><![CDATA[Alex]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duré Benítez]]></surname>
<given-names><![CDATA[Milko Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Estigarribia Flecha]]></surname>
<given-names><![CDATA[Dahiana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gill Maidana]]></surname>
<given-names><![CDATA[Héctor Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Giménez Sánchez]]></surname>
<given-names><![CDATA[Patricia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez Figueredo]]></surname>
<given-names><![CDATA[Carlos Joel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Ramírez]]></surname>
<given-names><![CDATA[Edgar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López González]]></surname>
<given-names><![CDATA[Liliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Núñez González]]></surname>
<given-names><![CDATA[Emanuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Privada del Este Facultad de Medicina ]]></institution>
<addr-line><![CDATA[Asunción ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<volume>7</volume>
<numero>1</numero>
<fpage>10</fpage>
<lpage>19</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932020000100010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932020000100010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932020000100010&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Antecedentes:  el síndrome de QT prolongado (SQTP) adquirido se asocia al uso de ciertos fármacos. La detección oportuna del SQTP permite tomar medidas para prevenir arritmias ventriculares potencialmente letales.  Objetivo:  determinar la frecuencia de SQTP en pacientes adultos internados en Servicios de Clínica Médica, describir las características demográficas, clínicas, laboratoriales y el uso de fármacos asociados con la prolongación del intervalo QTc.  Materiales y métodos:  se aplicó diseño observacional, prospectivo, longitudinal, en varones y mujeres, mayores de 16 años de edad, internados en el Servicio de Clínica Médica del Hospital Nacional (Itauguá, Paraguay) y del Hospital Militar Central (Asunción, Paraguay) en 2019. Se midieron variables demográficas, clínicas, laboratoriales y un electrocardiograma (ECG) al ingreso y a la semana de internación. Se consideró STQL todo valor del intervalo QTc &#8805;0,45 seg en hombres y &#8805;0,47 seg en mujeres.  Resultados:  ingresaron al estudio 257 sujetos, 55% varones y 45% mujeres, con edad media 58±20 años. Se detectó SQTP en 55 pacientes (21%). Los fármacos más utilizados en los pacientes con SQTP fueron omeprazol, furosemida, piracilina-tazobactam, tramadol, ondasentrón, amiodarona, salbutamol, ciprofloxacina, antirretrovirales, levofloxacina, metoclopramida y cotrimoxazol.  Conclusión: la frecuencia de SQTP fue 21%. La comorbilidad más frecuente fue la hipertensión arterial (62%). Los fármacos más utilizados en los pacientes con SQTP fueron los de uso común en las salas de Clínica Médica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background:  Acquired prolonged QT syndrome (SQTP) is associated with the use of certain drugs. Timely detection of SQTP allows measures to be taken to prevent potentially lethal ventricular arrhythmias.  Objective:  To determine the frequency of SQTP in adult patients admitted to Clinical Medicine Services, to describe the demographic, clinical, laboratory characteristics and the use of drugs associated with prolongation of the QTc interval.  Materials and methods:  Observational, prospective, longitudinal design was applied in men and women, over 16 years of age, admitted to the Clinical Medicine Service of the National Hospital (Itauguá, Paraguay) and the Central Military Hospital (Asunción, Paraguay) in 2019. Demographic, clinical, laboratory variables and an electrocardiogram (ECG) were measured at admission and at one week of hospitalization. All values &#8203;&#8203;of the QTc interval &#8805;0.45 sec in men and &#8805;0.47 sec in women were considered STQL.  Results:  Two hundred fifty-seven subjects, 55% men and 45% women, with a mean age of 58±20 years, entered the study. SQTP was detected in 55 patients (21%) while the most commonly used drugs in patients with SQTP were omeprazole, furosemide, piperacillin-tazobactam, tramadol, ondansetron, amiodarone, salbutamol, ciprofloxacin, antiretroviral drugs, levofloxacin, metoclopramide and cotrimoxazole.  Conclusion:  The frequency of SQTP was 21% and the most frequent comorbidity was arterial hypertension (62%). The most commonly used drugs in patients with SQTP were those commonly used in the Clinical Medicine rooms.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[síndrome de QT prolongado]]></kwd>
<kwd lng="es"><![CDATA[electrocardiografía]]></kwd>
<kwd lng="es"><![CDATA[arritmias cardiacas]]></kwd>
<kwd lng="es"><![CDATA[muerte súbita]]></kwd>
<kwd lng="es"><![CDATA[Medicina Interna]]></kwd>
<kwd lng="en"><![CDATA[prolonged QT syndrome]]></kwd>
<kwd lng="en"><![CDATA[electrocardiography]]></kwd>
<kwd lng="en"><![CDATA[cardiac arrhythmias]]></kwd>
<kwd lng="en"><![CDATA[sudden death]]></kwd>
<kwd lng="en"><![CDATA[Internal Medicine]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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