<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2312-3893</journal-id>
<journal-title><![CDATA[Revista Virtual de la Sociedad Paraguaya de Medicina Interna]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. virtual Soc. Parag. Med. Int.]]></abbrev-journal-title>
<issn>2312-3893</issn>
<publisher>
<publisher-name><![CDATA[Sociedad Paraguaya de Medicina Interna]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2312-38932019000100063</article-id>
<article-id pub-id-type="doi">10.18004/rvspmi/2312-3893/2019.06(01)63-074</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Factores asociados a la falta de adherencia al tratamiento en pacientes con diabetes mellitus tipo 2]]></article-title>
<article-title xml:lang="en"><![CDATA[Factors associated with lack of adherence to treatment in patients with type 2 diabetes mellitus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Domínguez Gallardo]]></surname>
<given-names><![CDATA[Laura Andrea]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortega Filártiga]]></surname>
<given-names><![CDATA[Edgar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Itapúa. Facultad de Medicina Postgrado en Medicina Interna.]]></institution>
<addr-line><![CDATA[Encarnación ]]></addr-line>
<country>Paraguay</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Médico Nacional. Hospital Nacional. Dpto. de Medicina Interna]]></institution>
<addr-line><![CDATA[Itauguá ]]></addr-line>
<country>Paraguay</country>
</aff>
<pub-date pub-type="pub">
<day>01</day>
<month>03</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>01</day>
<month>03</month>
<year>2019</year>
</pub-date>
<volume>6</volume>
<numero>1</numero>
<fpage>63</fpage>
<lpage>74</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_arttext&amp;pid=S2312-38932019000100063&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_abstract&amp;pid=S2312-38932019000100063&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.iics.una.py/scielo.php?script=sci_pdf&amp;pid=S2312-38932019000100063&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la diabetes mellitus es una enfermedad prevalente y con un alto costo para la salud pública. No obstante, la falta de cumplimiento terapéutico se relaciona con un aumento de la morbimortalidad.  Objetivo:  determinar los factores asociados a la falta de adherencia al tratamiento en pacientes con diabetes mellitus tipo 2 que acuden al Hospital Nacional de Itauguá en 2018.  Material y métodos:  estudio observacional, descriptivo, prospectivo, de corte longitudinal, con componente analítico, realizado en hombres y mujeres mayores de 18 años con diagnóstico de diabetes mellitus tipo 2 que acudieron en forma ambulatoria a los consultorios del programa de diabetes del Hospital Nacional de Itauguá en 2018. La adherencia al tratamiento fue determinada con dos escalas validadas que midieron la adherencia farmacológica (Morisky-Green) y no farmacológica (IMEVID).  Resultados:  se estudiaron 338 pacientes, siendo 66% de sexo femenino. La edad media fue 56±7 años. La frecuencia de falta de adherencia al tratamiento fue 70% y los factores que se asociaron significativamente fueron la presencia de complicaciones crónicas (53%), la monoterapia farmacológica (35%), la presencia de efectos adversos medicamentosos (17%), el tiempo de evolución mayor a diez años (16%) y la mala relación médico-paciente (16%).  Conclusiones:  existe una alta frecuencia de falta de adherencia al tratamiento en pacientes con diabetes mellitus (70%). La presencia de complicaciones crónicas y la monoterapia farmacológica fueron los factores más frecuentemente asociados. Esta información permitirá la toma de decisiones para ayudar a los pacientes a mejorar su cumplimiento terapéutico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Diabetes mellitus is a prevalent disease with a high cost for public health. However, the lack of therapeutic compliance prevents that the morbidity and mortality associated with this pathology can be avoided.  Objective: To determine the factors associated with the lack of adherence to treatment in patients with type 2 diabetes mellitus who attend the National Hospital of Itauguá in 2018.  Material and methods: Observational, descriptive, prospective, longitudinal study, with analytical component, carried out in men and women older than 18 years with diagnosis of type 2 diabetes mellitus who attended the outpatient clinics of the National Hospital diabetes program in Itauguá in 2018. Adherence to treatment was determined with two validated scales that measured pharmacological (Morisky-Green) and non-pharmacological (IMEVID) adherence.  Results: Three hundred and thirty eight patients were studied, 66% being female. The average age was 56 ± 7 years. The frequency of lack of adherence to treatment was 70% and the factors that were significantly associated were the presence of chronic complications (53%), pharmacological monotherapy (35%), presence of adverse drug effects (17%), time of evolution greater than ten years (16%) and poor doctor-patient relationship (16%).  Conclusions: There is a high frequency of lack of adherence to treatment in patients with diabetes mellitus (70%). The presence of chronic complications and pharmacological monotherapy were the most frequently associated factors. This information will allow decision-making to help patients improve their therapeutic compliance.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[adherencia terapéutica]]></kwd>
<kwd lng="es"><![CDATA[factores de riesgo]]></kwd>
<kwd lng="es"><![CDATA[diabetes mellitus]]></kwd>
<kwd lng="en"><![CDATA[therapeutic adherence]]></kwd>
<kwd lng="en"><![CDATA[risk factors]]></kwd>
<kwd lng="en"><![CDATA[diabetes mellitus]]></kwd>
</kwd-group>
</article-meta>
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