2312-3893 2312-3893 S2312-38932018000200012 10.18004/rvspmi/2312-3893/2018.05(02)12-018 Paraguay Paraguay 00 09 2018 00 09 2018 5 2 12 18

1 Centers for Disease Control and Prevention. 2018 2 2017 42 3 3 180-8 3 US Departament of Justiced, Drug Enforcement Administration, Diversion Control Division. 4 2018 5 United States. Department of Justice, Drug Enforcement Administration. 6 U.S. Food and Drug Administration 7 European Medicines Agency 2016 8 2015 29 3 3 639-42 9 2015 12 46 10 2015 7 1 1 28-31 11 National Institute on Drug Abuse 2018 12 ProCon.org 2016 13 2016 13 3-4 3-4 13-22 14 International Union of Basic and Clinical Pharmacology 2010 62 2 2 588-631 15 2017 42 3 3 180-8 16 2016 1 1 1 102-12 17 2014 46 1 1 86-95 18 2014 20 4112-8 19 National Academies of Sciences, Engineering, and Medicine. 2017 20 2017 167 5 5 319-31 21 2013 131 3 3 263-70 22 2017 42 9 9 1752-65 23 Australian Government, Department of Health, Therapeutic Goods Administration 2017 24 2014 73 Suppl 2 Suppl 2 1177 25 2016 7 2 2 26 2018 22 1 1 8 27 2018 X 18 18 30047-2 28 2018 22 3 3 455-70 29 2016 30 1 1 47-61 30 2015 313 24 24 2456-73 31 2017 114 38 38 627-34 32 2018 25 Suppl 1 Suppl 1 33 2017 6 Suppl 2 Suppl 2 S215-22 34 2018 84 4 4 213 35 2018 49 2-6 36 2018 22 3 3 440-54